Results 71 to 80 of about 47,866 (282)

Psoralen and ultraviolet A light treatment directly affects phosphatidylinositol 3-kinase signal transduction by altering plasma membrane packing [PDF]

, 2016
Psoralen and ultraviolet A light (PUNTA) are used to kill pathogens in blood products and as a treatment of aberrant cell proliferation in dermatitis, cutaneous T-cell lymphoma, and graft versus-host disease.
Compernolle, Veerle, Devloo, Rosalie, Feys, Hendrik, Sandra, Koen, t'Kindt, Ruben, Van Aelst, Britt, Vandekerckhove, Philippe, Zachée, Pierre   +7 more
core   +2 more sources

CXCL6 Reshapes Lipid Metabolism and Induces Neutrophil Extracellular Trap Formation in Cholangiocarcinoma Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
CXCL6's function in cholangiocarcinoma is underexplored. Here it is discovered that CXCL6 is upregulated in cholangiocarcinoma tissues and promotes proliferation and metastasis of it. CXCL6 functions through the CXCR1/2‐JAK‐STAT/PI3K axis and reshaping tumor lipid metabolism.
Tian He, Zi‐Yi Wang, Bin Xu, Cheng‐Jie Zhong, Lu‐Na Wang, Huan‐Chen Shi, Zi‐Yue Yang, Shi‐Qi Zhou, Hui Li, Bo Hu, Xiao‐Dong Zhu, Ying‐Hao Shen, Jian Zhou, Jia Fan, Hui‐Chuan Sun, Cheng Huang   +15 more
wiley   +1 more source

A Pre-transplant Blood-based Lipid Signature for Prediction of Antibody-mediated Rejection in Kidney Transplant Patients [PDF]

, 2020
Purpose. The aim of this study is to demonstrate the potential of the pre-transplant lipidome to predict post-transplant antibody-mediated rejection (AMR) in kidney transplant patients. Methods.
Al sultan, Monther, Alshammari, Suad, Bobba, Sindhura, Contaifer, Daniel, Jr., Gupta, Gaurav, Kimball, Pamela, King, Anne, Kumar, Dhiren, Levy, Marlon, Morriss, Joshua, Stern, Jeffrey, Wijesinghe, Dayanjan   +11 more
core   +1 more source

Unraveling Tissue‐Specific Fatty Acid Biosynthesis and Inter‐Tissue Crosstalk in Mice through Stable‐Isotope Tracing Metabolomics

Advanced Science, EarlyView.
Biosynthesis rates of 13 FFAs are quantitatively calculated in 15 tissues from glucose and an analytical framework to quantitatively calculate inter‐tissue communications of fatty acids between the liver and other tissues is developed. Moreover, the approach is extended to aging condition and a system‐wide decline of fatty acid synthesis in peripheral ...
Beizi Xing, Ruohong Wang, Tianzhang Kou, Wenbin Liu, Zheng‐Jiang Zhu   +4 more
wiley   +1 more source

An in silico MS/MS library for automatic annotation of novel FAHFA lipids. [PDF]

, 2015
BackgroundA new lipid class named 'fatty acid esters of hydroxyl fatty acids' (FAHFA) was recently discovered in mammalian adipose tissue and in blood plasma and some FAHFAs were found to be associated with type 2 diabetes.
Fahrmann, Johannes F, Fiehn, Oliver, Gennity, Ingrid, Kind, Tobias, Ma, Yan, Vaniya, Arpana   +5 more
core   +2 more sources

Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset

Advanced Science, EarlyView.
This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu, Zhengyuan Zhou, Sascha Schäuble, Wolfgang Vivas, Karen Dlubatz, Michael Bauer, Sebastian Weis, Mervyn Singer, Roman Lukaszewski, Gianni Panagiotou   +9 more
wiley   +1 more source

Flexibility of a Eukaryotic Lipidome – Insights from Yeast Lipidomics

PLoS ONE, 2012
Mass spectrometry-based shotgun lipidomics has enabled the quantitative and comprehensive assessment of cellular lipid compositions. The yeast Saccharomyces cerevisiae has proven to be a particularly valuable experimental system for studying lipid-related cellular processes.
Felix Meyenhofer, Mathias J. Gerl, Kai Simons, Michal A. Surma, Andrej Shevchenko, Christian Klose   +5 more
openaire   +5 more sources

PHOSPHO1 Suppresses Ferroptosis in Retinal Pigment Epithelial Cells by Reducing the Levels of Phosphatidylethanolamine Molecular Species

Advanced Science, EarlyView.
Iron‐induced lipid peroxidation of phosphatidylethanolamine (PE) species is the key driver of ferroptosis. The authors discovered that PHOSPHO1 lowers the level of PE in retinal pigment epithelial cells thus reducing the formation of lipid peroxides. Lowering PE levels can also prevent the creation of autolysosomes, reduce the production of free iron ...
Zhiyang Chen, Xiaoman Zhu, Michael Mingze Lu, Qingjian Ou, Xueying Wang, Zhenzhen Zhao, Qi Shen, Qian Wang, Zhe Wang, Jing‐Ying Xu, Caixia Jin, Furong Gao, Juan Wang, Jingfa Zhang, Jieping Zhang, Xiaoliang Jin, Yanlong Bi, Lixia Lu, Guo‐Tong Xu, Haibin Tian   +19 more
wiley   +1 more source

Longitudinal Metabolomics in Amyotrophic Lateral Sclerosis Implicates Impaired Lipid Metabolism

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by altered metabolome and energy homeostasis, manifesting with body mass index changes and hypermetabolism—both prognostic of disease progression and survival.
Kai Guo, Masha G. Savelieff, Dae‐Gyu Jang, Samuel J. Teener, Lili Zhao, Junguk Hur, Stephen A. Goutman, Eva L. Feldman   +7 more
wiley   +1 more source

Examination of the Brain Mitochondrial Lipidome Using Shotgun Lipidomics [PDF]

, 2009
Contamination from subcellular organelles and myelin has hindered attempts to characterize the lipidome of brain mitochondria. A high degree of mitochondrial purity is required for accurate measurements of the content and molecular species composition of mitochondrial lipids.
Michael A. Kiebish, Xianlin Han, Thomas N. Seyfried   +2 more
openaire   +3 more sources