Results 81 to 90 of about 35,333 (282)
Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery
Advanced Science, EarlyView.Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra +6 more
wiley +1 more source
Nature CommunicationsRibosomes are regulated by evolutionarily conserved ubiquitination/deubiquitination events. We uncover the role of the deubiquitinase OTUD6 in regulating global protein translation through deubiquitination of the RPS7/eS7 subunit on the free 40 S ...
Sammy Villa +8 more
doaj +1 more source
Lipidomics of Huntington’s Disease: A Comprehensive Review of Current Status and Future Directions
MetabolitesBackground: Huntington’s disease (HD) is a multifaceted neurological disorder characterized by the progressive deterioration of motor, cognitive, and psychiatric functions.
Ali Yilmaz +5 more
doaj +1 more source
Journal of Lipid Research, 2007 Profiling of leaf extracts from mutants of Arabidopsis with defects in lipid desaturation demonstrates the utility of collision-induced dissociation time-of-flight mass spectrometry (CID-TOF MS) for screening biological samples for fatty acid ...
Steven Wynn Esch +8 more
doaj +1 more source
GPX4 Inhibitor Resistance and Metastatic Features in Triple‐Negative Breast Cancer
Advanced Science, EarlyView.This study establishes breast cancer cell lines that are resistant to glutathione peroxidase 4 inhibitors (GPX4i) in vitro and investigates the metastatic capacity of the GPX4i‐resistant versus parental lines in vivo. GPX4i‐resistant cells survive upon intravenous injection, but lose capacity to spontaneously metastasize.
Marie Sabatier +16 more
wiley +1 more source
Application of Lipidomics in the Researches of Food Quality
Shipin gongye ke-jiLipidomics, as a metabolomics approach centered on lipids, aims to comprehensively analyze lipids within biological systems. In recent years, mass spectrometry (MS)-based lipidomics analysis techniques have been widely utilized to address qualitative and
Haolei HAN +5 more
doaj +1 more source
Lipidomics unveils the complexity of the lipidome in metabolic diseases
Clinical and Translational Medicine, 2018 Dysregulation of lipid metabolism is responsible for pathologies of human diseases including metabolic diseases. Recent advances in lipidomics analysis allow for the targeted and untargeted identification of lipid species and for their quantification in ...
Todd A. Lydic, Young-Hwa Goo
doaj +1 more source
Advanced Intelligent Discovery, EarlyView.Exosomes are emerging as powerful biomarkers for disease diagnosis and monitoring. This review highlights the integration of surface‐enhanced Raman spectroscopy with artificial intelligence to enhance molecular fingerprinting of exosomes. Machine learning and deep learning techniques improve spectral interpretation, enabling accurate classification of ...
Munevver Akdeniz +2 more
wiley +1 more source
Phospholipid Profiling Established by Structure-Rich Fragments for Molecular Species Level Shotgun Analysis. [PDF]
Rapid Commun Mass SpectromABSTRACT Rationale Accurate identification of phospholipid molecular species remains a major challenge in shotgun lipidomics because conventional tandem mass spectrometry typically resolves only one structural moiety at a time. This structural ambiguity limits confident lipid biomarker discovery and biological interpretation.
Chen R +4 more
europepmc +2 more sources