Results 81 to 90 of about 57,903 (321)

Serum Metabolome and Lipidome Changes in Adult Patients with Primary Dengue Infection [PDF]

, 2013
10.1371/journal.pntd.0002373PLoS Neglected Tropical ...
A Mangerich, A Mathew, A Sreekumar, A Zuniga, AL St John, B Brugger, BR Murphy, C Lu, C Rothwell, CF Nathan, Choon Nam Ong, CN Serhan, CN Serhan, DJ Gubler, DJ Gubler, DL Diamond, DP Ng, E Avota, E Sandalova, E Zaitseva, E Zigmond, EC Laiakis, EG Bligh, EL Azeredo, Eng Eong Ooi, F Facciotti, Fengguo Xu, G Birungi, G Hasko, GF Nixon, J Chen, J Guarner, J Herz, J Mattner, J Xia, JC Suvarna, JG Low, JG Low, JH Yang, JK Nicholson, K Izawa, K Jessie, K Myo, Kun Lu, L Gil, Liang Cui, MC Ruzek, ME Miller, MG Guzman, N Vinayavekhin, NS Heaton, P Klassen, PC Calder, PC Neves-Souza, PG Hellewell, PJ Brennan, R Al-Mubarak, R Takhampunya, RA Lewis, RC Seet, RL Shaner, RW Wannemacher Jr, S Noisakran, SB Halstead, Scott F. Michael, SJ Gagnon, SL Tilley, Steven R. Tannenbaum, T Akaike, T Kawano, T Pluskal, TJ Nevalainen, W Shi, WW Goh, X Han, Y Kumar, YA Hannun, Yadunanda Kumar, Yie Hou Lee, Z Wang   +79 more
core   +4 more sources

Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling

Advanced Science, EarlyView.
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi, Yue Qi Ong, Prativa Majee, Esther SM Wong, Amhed Missael Vargas Velazquez, Kerem Fidan, Pierce Kah‐Hoe Chow, Wai Leong Tam, Ker Kan Tan, Iain Beehuat Tan, Vinay Tergaonkar   +10 more
wiley   +1 more source

Pregnancy lipidomic profiles and DNA methylation in newborns from the CHAMACOS cohort. [PDF]

, 2019
Lipids play a role in many biological functions and the newly emerging field of lipidomics aims to characterize the varying classes of lipid molecules present in biological specimens.
Bradman, Asa, Eskenazi, Brenda, HOLLAND, Nina, Huen, Karen, Lee, Douglas, Tindula, Gwen   +5 more
core  

Interaction Analysis of Repeated Measure Data [PDF]

, 2020
Extensive penalized variable selection methods have been developed in the past two decades for analyzing high dimensional omics data, such as gene expressions, single nucleotide polymorphisms (SNPs), copy number variations (CNVs) and others.
Jiang, Yu, Li, Xiaoxi, Ren, Jie, Wu, Cen, Zhou, Fei   +4 more
core  

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

Advanced Science, EarlyView.
This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta, Jonas Bossart, Sènan Mickael D'Almeida, Luis Augusto Visani de Luna, Christoph Schwärzler, Tingting Fu, Vanesa Ayala‐Nunez, Alexander Gogos, Marija Buljan, Vera M Kissling, Emmanuel Flahaut, Miguel Garcia, Cyrill Bussy, Peter Wick, Tina Buerki‐Thurnherr   +14 more
wiley   +1 more source

Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling. [PDF]

, 2017
Disruption of hepatocyte growth hormone (GH) signaling through disruption of Jak2 (JAK2L) leads to fatty liver. Previously, we demonstrated that development of fatty liver depends on adipocyte GH signaling.
Camporez, João Paulo G, Corbit, Kevin C, Deo, Rahul C, Edmunds, Lia R, Erion, Derek M, Jurczak, Michael J, Perry, Rachel J, Shulman, Gerald I, Tran, Jennifer L, Vera, Nicholas B, Weiss, Ethan J   +10 more
core   +1 more source

CRISPLD2 Attenuates Intervertebral Disc Degeneration by Suppressing Oxidative Stress‐Induced Ferroptosis through the miR‐548I‐IL17A Axis

Advanced Science, EarlyView.
This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi, Fudong Li, Tianyi Zhao, Kaiqiang Sun, Danying Zhang, Chen Yan, Ximing Xu, Jingchuang Sun, Xulin Hu, Xin Yong, Jiangang Shi, Yuan Wang   +11 more
wiley   +1 more source

Integrative brain omics approach highlights sn-1 lysophosphatidylethanolamine in Alzheimer’s dementia

Nature Communications
The biology of individual lipid species and their relevance in Alzheimer’s disease (AD) remains incompletely understood. To explore the lipidomic biomarkers associated with cognition function and neuropathological changes in AD, we utilize non-targeted ...
Chih-Yu Chen, Kristal Maner-Smith, Manoj Khadka, Jun Ahn, Xueyun L. Gulbin, Anna A. Ivanova, Eric B. Dammer, Nicholas T. Seyfried, David A. Bennett, Ihab M. Hajjar, Eric A. Ortlund   +10 more
doaj   +1 more source

Identification of a Widespread Palmitoylethanolamide Contamination in Standard Laboratory Glassware. [PDF]

, 2017
Introduction: Fatty acid ethanolamides (FAEs) are a family of lipid mediators that participate in a host of biological functions. Procedures for the quantitative analysis of FAEs include organic solvent extraction from biological matrices (e.g., blood ...
Angelini, Roberto, Argueta, Donovan A, DiPatrizio, Nicholas V, Piomelli, Daniele   +3 more
core  

The lipidomic signature of adult patients with non-alcoholic fatty liver disease. An interim analysis of a prospective study [PDF]

, 2023
Georgios Kalopitas, Thomai Mouskeftara, Michail Chourdakis, L. Kougias, V. Rafailidis, Emmanouil Sinakos, Helen Gkika, Georgios Germanidis   +7 more
openalex   +1 more source