Results 71 to 80 of about 8,324 (204)

Value of urinary lipoarabinomannan levels for tuberculosis diagnosis and monitoring of therapy

Frontiers in Microbiology
BackgroundThe urinary lipoarabinomannan (LAM) assay has emerged as a promising tool for tuberculosis (TB) diagnosis and treatment monitoring. This study aimed to evaluate the diagnostic and monitoring performance of LAM compared to Acid-fast bacilli (AFB)
Yiqun Xiong, Zhihong Shen, Bo Dong, Ying Wang, Ying Zhu, Hongxia Wei, Dongliang Zhang, Yang Che   +7 more
doaj   +1 more source

Role of detection of lipoarabinomannan (LAM) in urine for diagnosis of pulmonary tuberculosis in HIV patients: Egyptian experience

The Egyptian Journal of Bronchology, 2021
Background Tuberculosis remains a worldwide problem fueled by the HIV epidemic. TB infection impacts HIV progression and mortality even with treatment. Egypt has increasing HIV prevalence, although still in low prevalent areas.
Nagwa Elhalawany, Nessrin Shalaby, Amal Fathy, Ahmed S. Elmorsy, Mohamed Zaghloul, Heba El-shahawy, Asem A. Hewidy   +6 more
doaj   +1 more source

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

MedComm, Volume 7, Issue 9, September 2026.
This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu, Yuqin Jin, Baochao Li, Jie Deng, Yiwen Zhou, Jinglun Zhang, Huang Li   +6 more
wiley   +1 more source

Monoclonal antibodies from humans with Mycobacterium tuberculosis exposure or latent infection recognize distinct arabinomannan epitopes

Communications Biology, 2021
Elise Ishida et al. generate human monoclonal antibodies that can selectively recognize specific oligosaccharide epitopes of the polysaccharides arabinomannan and lipoarabinomannan, which are critical for M. tuberculosis pathogenesis.
Elise Ishida, Devin T. Corrigan, Ryan J. Malonis, Daniel Hofmann, Tingting Chen, Anita G. Amin, Delphi Chatterjee, Maju Joe, Todd L. Lowary, Jonathan R. Lai, Jacqueline M. Achkar   +10 more
doaj   +1 more source

Pathogenesis of Tuberculosis: Interplay Between Host Antituberculosis Immunity and Immune Evasion Strategies of Mycobacterium Tuberculosis

MedComm, Volume 7, Issue 8, August 2026.
Mycobacterium tuberculosis–host interactions and infection outcomes. Following initial infection, alveolar macrophages phagocytose the pathogen, prompting the recruitment of innate immune cells including neutrophils, NK cells, and interstitial macrophages.
Xiaojuan Zhang, Ying Liu, Yilin Hou, Hongxia Niu   +3 more
wiley   +1 more source

Identification and characterization of endo-α-, exo-α-, and exo-β-d-arabinofuranosidases degrading lipoarabinomannan and arabinogalactan of mycobacteria

Nature Communications, 2023
The cell walls of pathogenic and acidophilic bacteria, such as Mycobacterium tuberculosis and Mycobacterium leprae, contain lipoarabinomannan and arabinogalactan.
Michiko Shimokawa, Akihiro Ishiwata, Toma Kashima, Chiho Nakashima, Jiaman Li, Riku Fukushima, Naomi Sawai, Miku Nakamori, Yuuki Tanaka, Azusa Kudo, Sae Morikami, Nao Iwanaga, Genki Akai, Nobutaka Shimizu, Takatoshi Arakawa, Chihaya Yamada, Kanefumi Kitahara, Katsunori Tanaka, Yukishige Ito, Shinya Fushinobu, Kiyotaka Fujita   +20 more
doaj   +1 more source

Pam3CSK4 As a Second Hit in NLRP3‐Dependent Activation of Monocytes Primed With Antiphospholipid Antibodies

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Pam3CSK4 amplifies aPL‐induced monocyte activation. This results in thromboinflammatory activation that may contribute to APS‐related vascular pathology. ABSTRACT Antiphospholipid antibodies (aPL) are drivers of inflammation and thrombosis in antiphospholipid syndrome (APS). However, the molecular mechanisms underlying infection‐induced exacerbation of
Anush Martirosyan, Eva Kriegova, Jana Ulehlova, Zaven Karalyan, Tomas Papajik, Gayane Manukyan   +5 more
wiley   +1 more source

Sputum lipoarabinomannan (LAM) as a biomarker to determine sputum mycobacterial load: exploratory and model-based analyses of integrated data from four cohorts

BMC Infectious Diseases, 2022
Background Despite the high global disease burden of tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (Mtb) infection, novel treatments remain an urgent medical need.
Aksana Jones, Jay Saini, Belinda Kriel, Laura E. Via, Yin Cai, Devon Allies, Debra Hanna, David Hermann, Andre G. Loxton, Gerhard Walzl, Andreas H. Diacon, Klaus Romero, Ryo Higashiyama, Yongge Liu, Alexander Berg   +14 more
doaj   +1 more source

Synthesis of a Miniature Lipoarabinomannan

, 2015
: An analog of Mycobacterium tuberculosis lipoarabinomannan (LAM) has been synthesized containing the characteristic structures of all of its three major components; that is, a mannosylated phosphatidylinositol moiety, an oligomannan, and an ...
Lizhen Wang (340620), Zhongwu Guo (673969), Zhongwu Guo, Guochao Liao, Jian Gao (307118), Jian Gao, Guochao Liao (1307163), Lizhen Wang   +7 more
core   +1 more source

Advancements in LAM-based diagnostic kit for tuberculosis detection: enhancing TB diagnosis in HIV-negative individuals

Frontiers in Microbiology
ObjectiveThe purpose of this study was to investigate the diagnostic value of urine lipoarabinomannan (LAM) detection based on chemiluminescence assay for pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) in HIV-negative individuals ...
Man Gao, Qianhong Wu, Xinhong Wang, Xiuli Sun, Meng Li, Guanghong Bai   +5 more
doaj   +1 more source