Results 81 to 90 of about 8,324 (204)

The Dual Roles of Regulatory B Cells in Infection, Cancer, and Immunity

MedComm, Volume 7, Issue 7, July 2026.
Regulatory B cells maintain immune homeostasis via suppressive cytokines and surface molecules like PD‐L1. While beneficially suppressing autoimmunity and promoting transplant tolerance, these identical mechanisms detrimentally attenuate antipathogen and antitumor immune responses.
Anni Feng, Qilong Li, Ning Jiang, Qijun Chen   +3 more
wiley   +1 more source

Predictive and prognostic properties of TB-LAM among HIV-positive patients initiating ART in Johannesburg, South Africa

The Pan African Medical Journal, 2015
While the diagnostic properties of the TB LAM urine assay (LAM) have been well-described, little is known about its predictive and prognostic properties at ART initiation in a routine clinic setting.
Alexander déElia, Denise Evans, Lynne McNamara, Rebecca Berhanu, Ian Sanne, Elisabet Lénnermark   +5 more
doaj   +1 more source

Bioconjugation Strategies for Revealing the Roles of Glycerophospholipids in Cells

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Glycerophospholipids are the main class of phospholipids, essential for membrane structure, compartmentalization, and cellular signaling. To study their roles, innovative probes and advanced bioconjugation strategies have been developed, including by de novo lipid synthesis and bioorthogonal conjugation chemistry.
Brice Beauvais, Rajendra Rohokale, Sevin Mamputu, Ion Lupu, Zhongwu Guo, Sébastien Balieu   +5 more
wiley   +1 more source

Access to diagnosis using liquid biopsy (ADLiB): Identifying lymphoma in a tuberculosis‐endemic setting

HemaSphere, Volume 10, Issue 6, June 2026.
Abstract In HIV‐ and tuberculosis (TB)‐endemic regions, lymphoma diagnosis is often delayed because symptoms can overlap with TB, and access to biopsy and specialized pathology is limited. To address this, we developed and internally evaluated the Access to Diagnosis using Liquid Biopsy (ADLiB) platform—a plasma cell‐free DNA (cfDNA)‐based approach ...
Katherine Antel, Nina Xiong, Mwanasha Merrill, Taiyang Chen, Lauren McGrath, Clara Droessler, Maxine van der Schyff, Meng‐Xuan Wu, Dylan Cheddie, Charlotte Slome, Liam McBride, Jonathan Day, Zainab Mohamed, Nazia Fakie, Nomonde Mbatani, Charlotte Shultz, Graeme Meintjes, Svitlana Tyekucheva, Elizabeth F. Cohen, Michael Y. Tolstorukov, Estelle Verburgh, Mark A. Murakami   +21 more
wiley   +1 more source

Stratification of chronic rhinosinusitis with nasal polyps by distinct sinonasal microbial communities and their clinical and pathological correlations

iMetaOmics, Volume 3, Issue 2, June 2026.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory condition. Dysbiosis is commonly observed. This study identified distinct sinonasal microbial communities in CRSwNP patients and explored their clinical and pathological associations. Two distinct microbial communities were identified: community type 1 (CT1), dominated by
Bixing Fang, Yanmin Liu, Qing Bao, Lin Sun, Hexin Chen, Qingxiang Meng, Linyi Jiao, Xiaoyan Ye, Jian Li, Tao Ding, Chunwei Li   +10 more
wiley   +1 more source

Arabinogalactan and lipoarabinomannan biosynthesis: structure, biogenesis and their potential as drug targets.

, 2012
Mycobacterium tuberculosis, the etiological agent of TB, remains the leading cause of mortality from a single infectious organism. The persistence of this human pathogen is associated with its distinctive lipid-rich cell wall structure that is highly ...
Jankute, Monika, Grover, Shipra, Besra, Gurdyal; id_orcid, Rana, AK   +3 more
core   +1 more source

Lipoarabinomannan. Multiglycosylated form of the mycobacterial mannosylphosphatidylinositols.

Journal of Biological Chemistry, 1992
The lipopolysaccharides of mycobacteria, lipoarabinomannan (LAM) and lipomannan (LM), of key importance in host-pathogen interaction, were recently shown to contain a phosphatidylinositol "anchoring domain." We now have established that LAM and LM are based on the phosphatidylinositol mannosides, the characteristic glycophospholipids of mycobacteria ...
D, Chatterjee, S W, Hunter, M, McNeil, P J, Brennan   +3 more
openaire   +2 more sources

Pulmonary Aspergillosis Treated With Oral Amphotericin B (MAT2203) in a Patient With HIV‐Related Cryptococcal Meningitis

Clinical Case Reports, Volume 14, Issue 5, May 2026.
Graphical abstract for a case of a 26‐year‐old female with advanced HIV disease, cryptococcal meningitis, and co‐infection with pulmonary aspergillosis. Both co‐infections were successfully treated with the novel oral lipid nanocrystal formulation of amphotericin B (MAT2203).
Enock Kagimu, Elizabeth Senkoro, Jane Gakuru, Morris K. Rutakingirwa, David R. Boulware, David B. Meya, Richard Kwizera   +6 more
wiley   +1 more source

Spearman's rank correlation coefficients for factors associated with urine lipoarabinomannan (LAM) ELISA optical densities among patients testing urine LAM positive (n = 23).

, 2014
Spearman's rank correlation coefficients for factors associated with urine lipoarabinomannan (LAM) ELISA optical densities among patients testing urine LAM positive (n = 23).
Stephen D. Lawn (116037), Robin Wood (4924), Andrew D. Kerkhoff (116024), Monica Vogt (212258)   +3 more
core   +1 more source

A new role for lipoproteins LpqZ and FecB in orchestrating mycobacterial cell envelope biogenesis

mBio
Accounting for more deaths than any other bacterial species, Mycobacterium tuberculosis (Mtb) represents a critical threat to public health worldwide. A key factor contributing to Mtb’s virulence is its unique cell envelope, which acts as a protective ...
Robin Lissner, Aaron Franklin, Samuel T. Benedict, Vicky Charitou, Alexander Speer, Jaco Knol, Connie Jimenez, Patrick J. Moynihan, Sergey Nejentsev, Coen Kuijl, Wilbert Bitter   +10 more
doaj   +1 more source