Results 51 to 60 of about 8,324 (204)

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Correction: LprG-Mediated Surface Expression of Lipoarabinomannan Is Essential for Virulence of Mycobacterium tuberculosis

, 2014
Correction: LprG-Mediated Surface Expression of Lipoarabinomannan Is Essential for Virulence of Mycobacterium ...
PLOS Pathogens (2206624)
core   +1 more source

Quantification of bactericidal activity using the PATHFAST TB LAM Ag assay during the first 14 days of pulmonary tuberculosis treatment

Frontiers in Antibiotics
BackgroundTuberculosis (TB) remains a global health challenge. Culture-free, rapid, and quantitative biomarkers to monitor treatment response are critical to accelerate development of better TB treatments.
Ayumi Akinaga, Andreas H. Diacon, Remous Ocloo, Atsushi Yanagida, Naofumi Yoda, Masanori Kawasaki, Yongge Liu   +6 more
doaj   +1 more source

Feasibility and clinical outcomes of routine point‐of‐care screening for opportunistic infections among people with advanced HIV disease in Guyana

HIV Medicine, EarlyView.
Abstract Objectives We evaluated the feasibility and outcomes of implementing comprehensive Point‐of‐care (POC) opportunistic infections (OIs) screening among people with Advanced HIV disease (AHD) in Guyana. Methods We conducted a prospective multicentre cohort study across seven sites between February 2024 and March 2025.
Antonio Camiro‐Zúñiga, Tariq Jagnarine, Divya Shivdas, Lakshmi Narain, Kwesi Vanccoten, Kampta Prashad, Abiola Jacobs, Quacy Grant, Mallika Mootoo, Narissa Lawerence, Suzanne Siebs, Escalada Rainier, Omar Sued, Freddy Perez   +13 more
wiley   +1 more source

Lipoarabinomannan (LAM) detected by the Lipopolysaccaride (LPS) assay.

, 2013
Relation between Lipoarabinomannan (LAM) standard concentrations from the Enzyme-linked immunosorbent assay (ELISA) kit and Lipopolysaccaride (LPS) concentrations analysed by the Limulus Amebocyte Lysate colorimetric assay (LAL).
Siri L. Feruglio (433766), Marius Trøseid (433767), Jan Kristian Damås (281943), Dag Kvale (433768), Anne Ma Dyrhol-Riise (433769)   +4 more
core   +1 more source

Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy

Immunology &Cell Biology, EarlyView.
IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley   +1 more source

Mechanisms leading to lipoarabinomannan antigenuria.

, 2015
1. Renal TB 2. Passage of whole Mycobacterium tuberculosis through the glomerular basement membrane into the urine 3. Passage of LAM captured by immune-complexes through the glomerular basement membrane into the urine 4.
Janneke A. Cox (329523), Eric Van Marck (8462), Koen Van de Vijver (728115), Ann M. Nelson (329526), Andrew Kambugu (166978), Robert Colebunders (10697), Robert L. Lukande (329524), Yukari C. Manabe (249354), Sam Kalungi (728114)   +8 more
core   +1 more source

Structural and functional features of Rhodococcus ruber lipoarabinomannan

The genus Rhodococcus is part of the phylogenetic group nocardioform actinomycetes, which also includes the genus Mycobacterium. Members of this phylogenetic group have a characteristic cell envelope structure, which is dominated by various complex ...
Gibson KJC, Gilleron M, Constant P, Puzo G, Nigou J, Besra GS   +5 more
core   +4 more sources

Lateral-flow urine lipoarabinomannan for TB diagnosis in children. [PDF]

IJTLD Open
SUMMARY BACKGROUND Diagnosing childhood TB is challenging due to nonspecific symptoms and difficulty obtaining sputum samples. This study evaluated the urine-based Alere Determine™ TB-LAM Ag test (AlereLAM) in a high-burden TB, HIV, and malnutrition setting.
Mahajan R, Nyikayo LF, Peter Ajack YB, Chol BT, Sangma M, Ayor J, Sagrado MJ, Llosa AE, Moretó-Planas L.   +8 more
europepmc   +3 more sources

Harnessing Extracellular Vesicles for Precision Diagnostics and Infectious Disease Management: Integrating Host‐ and Pathogen‐Derived Cues

Exploration, Volume 6, Issue 5, October 2026.
This review summarizes the diagnostic and monitoring potential of host‐pathogen extracellular vesicles (hpEVs) in infectious diseases, advances in their isolation and analysis, and challenges to clinical translation. ABSTRACT Conventional infectious disease diagnostics often rely on detecting pathogen‐derived factors or an immune response directed ...
Ming Zhou, Yongchun Pan, Bo Ning, Christopher J. Lyon, Yang Liu, Tony Hu   +5 more
wiley   +1 more source