Results 41 to 50 of about 8,324 (204)
Urine Lipoarabinomannan for Tuberculosis Diagnosis: Evolution and Prospects [PDF]
Clinical Chemistry, 2018 Tuberculosis (TB)4 affects over 10 million people and kills 1.7 million each year. This devastating epidemic is unacceptable, as, given correct diagnosis and timely initiation of treatment, TB is curable. Unfortunately, case detection is the weakest step in the cascade of care, and about 40% of TB patients are either not diagnosed or not reported to ...
Emily, MacLean, Madhukar, Pai
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Advanced Biomedical Research, 2016 Background: Bacille Calmette–Guerin (BCG) vaccine is the only vaccine that is used against Mycobacterium tuberculosis, but its efficacy is limited in mycobacterium-endemic regions.
Mohammad Taghikhani, Rasul Moukhah
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Cells, 2022 Mycobacterium tuberculosis (M. tb) is an intracellular pathogen persisting in phagosomes that has the ability to escape host immune surveillance causing tuberculosis (TB).
Hanrui Liu +7 more
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Blood and urine early treatment response biomarkers in HIV-associated disseminated tuberculosis
Southern African Journal of HIV MedicineBackground: Treatment response biomarkers are needed in the care of patients hospitalised with HIV-associated tuberculosis (TB). Objectives: We describe the changes in bacillary load during early treatment using quantitative and semi-quantitative ...
Linda Boloko +9 more
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Genetics of Mycobacterial Arabinogalactan and Lipoarabinomannan Assembly
Microbiology Spectrum, 2014 ABSTRACT The cell wall of Mycobacterium tuberculosis is unique in that it differs significantly from those of both Gram-negative and Gram-positive bacteria. The thick, carbohydrate- and lipid-rich cell wall with distinct lipoglycans enables mycobacteria to survive under hostile conditions such as shortage ...
Monika, Jankute +3 more
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Mannose-capped lipoarabinomannan in Mycobacterium tuberculosis pathogenesis [PDF]
Pathogens and Disease, 2018 Mannose-capped lipoarabinomannan (ManLAM), present in all members of the Mycobacterium tuberculosis complex and in other pathogenic Mycobacterium spp, is a high molecular mass amphipathic lipoglycan with a defined critical role in mycobacterial survival during infection.
Joanne, Turner, Jordi B, Torrelles
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Frontiers in Immunology, 2018 Leprosy causes the most common peripheral neuropathy of infectious etiology, posing an important public health problem worldwide. Understanding the molecular and immunological mechanisms of nerve damage induced by M.
André Alan Nahas +4 more
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Biosynthesis of mycobacterial lipoarabinomannan: Role of a branching mannosyltransferase [PDF]
Proceedings of the National Academy of Sciences, 2006 Lipoarabinomannan (LAM), one of the few known bacterial glycosylphosphoinositides (GPIs), occurs in various structural forms in Mycobacterium species. It has been implicated in key aspects of the physiology of Mycobacterium tuberculosis and the ...
Devinder, Kaur +9 more
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Beilstein Journal of Nanotechnology, 2020 A number of bacterial glycans are specific markers for the detection and the serological identification of microorganisms and are also widely used as antigenic components of vaccines.
Gennady L. Burygin +5 more
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Enhanced immunogenicity of Mycobacterium bovis BCG through CRISPRi mediated depletion of AftC
The Cell Surface, 2022 Mycobacterium tuberculosis causes the disease tuberculosis and affects a third of the world’s population. The recent COVID-19 pandemic exacerbated the situation with a projected 27% increase in tuberculosis related deaths. M.
Bala T.S.A. Madduri +4 more
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