Results 31 to 40 of about 8,324 (204)

Synthesis of a Miniature Lipoarabinomannan

Organic Letters, 2014
Abstract An analog of Mycobacterium tuberculosis lipoarabinomannan (LAM) has been synthesized containing the characteristic structures of all of its three major components; that is, a mannosylated phosphatidylinositol moiety, an oligomannan, and an oligoarabinan.
Gao, Jian, Liao, Guochao, Wang, Lizhen, Guo, Zhongwu   +3 more
openaire   +2 more sources

Lipoarabinomannan in urine during tuberculosis treatment: association with host and pathogen factors and mycobacteriuria. [PDF]

, 2012
BACKGROUND: Detection of lipoarabinomannan (LAM), a Mycobacterium tuberculosis (Mtb) cell wall antigen, is a potentially attractive diagnostic. However, the LAM-ELISA assay has demonstrated variable sensitivity in diagnosing TB in diverse clinical ...
Vogt, Monica, Middelkoop, Keren, Vogt Monica, Lawn Stephen D, Middelkoop Keren, Lawn, Stephen, Lawn, Stephen D, Robin Wood, Kreiswirth, Barry N., Bekker Linda-Gail, Stephen D Lawn, Racow, Kimberly, Racow Kimberly, Barry N Kreiswirth, Kreiswirth, Barry N, Wood Robin, Linda-Gail Bekker, Lawn, Stephen D., Monica Vogt, Kreiswirth Barry N, Kreiswirth, Barry, Bekker, Linda-Gail, Wood, Robin, Kimberly Racow, Keren Middelkoop   +24 more
core   +2 more sources

Urine lipoarabinomannan for rapid tuberculosis diagnosis in HIV-infected adult outpatients in Khayelitsha

Southern African Journal of HIV Medicine, 2021
Background: Decreasing tuberculosis (TB) mortality is constrained by diagnostic and treatment delays. The World Health Organization (WHO) recently actively recommended the point-of-care Alere Determine Lipoarabinomannan Ag assay (AlereLAM) to assist in ...
Bianca Sossen, Amanda Ryan, Joanna Bielawski, Riana Greyling, Gillian Matthews, Sheetal Hurribunce-James, René Goliath, Judy Caldwell, Graeme Meintjes   +8 more
doaj   +1 more source

Evaluation of lipoarabinomannan for the serological diagnosis of tuberculosis [PDF]

Journal of Clinical Microbiology, 1990
The availability of highly purified lipoarabinomannan from Mycobacterium tuberculosis in its native acylated, highly antigenic state allowed its application to the serodiagnosis of tuberculosis in patients from the Republic of Mexico. Antilipoarabinomannan immunoglobulin G antibodies in sera from 66 patients with pulmonary, miliary, and pleural ...
E, Sada, P J, Brennan, T, Herrera, M, Torres   +3 more
openaire   +2 more sources

Determine TB-LAM lateral flow urine antigen assay for HIV-associated tuberculosis: recommendations on the design and reporting of clinical studies. [PDF]

, 2013
Detection of the Mycobacterium tuberculosis cell wall antigen lipoarabinomannan (LAM) in urine permits diagnoses of tuberculosis (TB) to be made in HIV-infected patients with advanced immunodeficiency.
Kerkhoff, Andrew D, Dorman, Susan, Peter, Jonathan, Nicol, Mark, Catharina C Boehme, Peter, Jonathan G, Boehme, Catharina C, Kerkhoff, Andrew, Nicol, Mark P, Keertan Dheda, Peter, Jonathan G., Lawn, Stephen, Lawn, Stephen D., Kerkhoff, Andrew D., Lawn, Stephen D, Dheda, Keertan, Mark P Nicol, Andrew D Kerkhoff, Nicol, Mark P., Jonathan G Peter, Boehme, Catharina, Stephen D Lawn, Susan Dorman, Boehme, Catharina C.   +23 more
core   +2 more sources

Clinical Utility of a Commercial LAM-ELISA Assay for TB Diagnosis in HIV-Infected Patients Using Urine and Sputum Samples [PDF]

, 2010
Background: The accurate diagnosis of TB in HIV-infected patients, particularly with advanced immunosuppression, is difficult. Recent studies indicate that a lipoarabinomannan (LAM) assay (Clearview-TB (R)-ELISA) may have some utility for the diagnosis ...
Peter, J, Peter Jonathan, Richard van Zyl Smit, Zumla, A, Green, Clare, Sechi Leonardo, Sechi, L, Badri Motasim, Hoelscher Michael, Dawson, R, Badri, M, Green, C, Blackburn, J, Whitelaw, Andrew, Laurence Brunet, Pai, Madhukar, Meldau, Richard, Sechi, Leonardo Antonio, Badri, Motasim, Andrew Whitelaw, Brunet Laurence, Zumla Alimuddin, Smit, Richard van Zyl, Whitelaw Andrew, Dawson Rodney, Dawson, Rodney, Dheda, Keertan, Clare Green, Brunet, Laurence, Davids, Virginia, Blackburn Jonathan, Zyl-Smit, Richard N. van, Lenders, Laura, Ling, D, Sharma, S, Roberts, Teri, Leonardo Sechi, Surendra Sharma, Madhukar Pai, Pai Madhukar, Meldau, R, Virginia Davids, Dheda, K, Sharma, Surendra, Daphne Ling, Jonathan Blackburn, Sharma Surendra, van Zyl Smit, Richard, Keertan Dheda, Davids Virginia, Rodney Dawson, Green Clare, Hoelscher, Michael, Lenders, L, Sechi, Leonardo, Teri Roberts, Michael Hoelscher, Richard Meldau, Roberts Teri, Lenders Laura, van Zyl Smit Richard, Peter, Jonathan, Davids, V, Whitelaw, A, Meldau Richard, Hoelscher, M, Ling, Daphne, Pai, M, Jonathan Peter, Motasim Badri, Blackburn, Jonathan, Zumla, Alimuddin, Dheda Keertan, Smit, RV, Roberts, T, Laura Lenders, Ling Daphne, Alimuddin Zumla, Brunet, L   +78 more
core   +1 more source

OPPORTUNITIES OF IMMUNODIAGNOSTICS OF TUBERCULOSIS IN THE PATIENTS AT ADVANCED STAGES OF HIV INFECTION

Туберкулез и болезни лёгких, 2018
The significance of lipoarabinomannan (LAM) level in blood serum for the confirmation of tuberculosis was analyzed in 106 patients at the advanced stages of HIV infection.
A. V. Dudchenko, N. L. Kаrpinа, M. M. Аverbаkh   +2 more
doaj   +1 more source

Immunological hyporesponsiveness in tuberculosis: The role of mycobacterial glycolipids

Frontiers in Immunology, 2022
Glycolipids constitute a major part of the cell envelope of Mycobacterium tuberculosis (Mtb). They are potent immunomodulatory molecules recognized by several immune receptors like pattern recognition receptors such as TLR2, DC-SIGN and Dectin-2 on ...
Margarida Correia-Neves, Margarida Correia-Neves, Margarida Correia-Neves, Jérôme Nigou, Zaynab Mousavian, Zaynab Mousavian, Zaynab Mousavian, Christopher Sundling, Christopher Sundling, Christopher Sundling, Gunilla Källenius, Gunilla Källenius   +11 more
doaj   +1 more source

Predictive Ability of Sonographic Characteristics Alone to Diagnose Tuberculous Pleural Effusions in a Resource-Limited Setting: A Cross-Sectional Pilot Study in Zambia. [PDF]

Trop Med Int Health
ABSTRACT Background Tuberculous pleural effusion (TPE), the second most common form of extra‐pulmonary tuberculosis (TB), remains difficult to diagnose due to low‐yield, invasive and often unavailable diagnostics in resource‐limited settings. This study aimed to evaluate the diagnostic accuracy of sonographic characteristics alone to predict TB ...
Zimba L, Gass SJ, Makasa MC, Haldeman MS.   +3 more
europepmc   +2 more sources

Lipoarabinomannan regulates septation in Mycobacterium smegmatis

, 2023
Abstract The growth and division of mycobacteria, which include several clinically relevant pathogens, deviate significantly from that of canonical bacterial models. Despite their Gram-positive ancestry, mycobacteria synthesize and elongate a diderm envelope asymmetrically from the poles, with the old pole elongating ...
Ian L. Sparks, Japinder Nijjer, Jing Yan, Yasu S. Morita   +3 more
openaire   +2 more sources