Results 101 to 110 of about 24,464,671 (254)

The role of inflammatory biomarkers RBP4, Lipocalin-2, and hsCRP in prediabetes and type 2 diabetes mellitus [PDF]

Journal of Medical Biochemistry
Background: Adipocytokines, along with macrophages infiltrating adipose tissue, contribute to chronic low-grade inflammation, which leads to insulin resistance and type 2 diabetes.
Ornek Diker Vesile, Serin Ozden, Yorulmaz Ertug Ebru, Baytekin Ozlem, Oguz Osman, Güvenen Güvenç   +5 more
doaj   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Up-regulation and activation of lipocalin-2 causes endothelial dysfunction and hypertension in obese mice

, 2014
Lipocalin-2 is an adipokine with pro-inflammatory properties which is upregulated in obese humans and animals. Augmented lipocalin-2 expression is implicated in the pathogenesis of obesity-associated cardiovascular abnormalities.
Song, Erfei, 宋二飛
core   +1 more source

A Specific tRNA Half, 3'tiRNA‐GlyGCC, Regulates Hypoxic Pulmonary Artery Smooth Muscle Cell Proliferation via Myrf‐Mediated Endoplasmic Reticulum Stress

Cell Proliferation, EarlyView.
A schematic diagram illustrating how 3′tiRNA‐GlyGCC promotes the endoplasmic reticulum stress (ERS) and proliferation in hypoxic pulmonary artery smooth muscle cells (PASMCs) by inhibiting the expression of myelin regulatory factor (Myrf), ultimately leading to pulmonary hypertension (PH).
Lixin Zhang, Xiaoyu Guan, Xiangrui Zhu, Yingying Hao, Ya Xu, Hao Yuan, Danni Gao, Hongxia Du, Jiayu Li, Weiwei Cao, Cui Ma, Xiaoying Wang   +11 more
wiley   +1 more source

Macrophage Lipid Homeostasis Drives IVDD via a Senescence‐Dependent Impairment of Efferocytosis

Cell Proliferation, EarlyView.
Intervertebral disc degeneration (IVDD) has been a leading cause of low back pain and lacks disease‐modifying therapies. Although dysregulated disc lipid metabolism is implicated, its impact on the immune microenvironment, particularly macrophages, remains unknown.
Jinyu Wang, Shiyong Ling, Qi Wang, Xuege Qiao, Jianpeng Xing, Siyang Ji, Linhui Han, Chen Yan, Zhishen Niu, Lei Yuan, Baolian Zhao, Kaiqiang Sun, Jiangang Shi   +12 more
wiley   +1 more source

Reducing Diagnostic Delay in Axial Spondyloarthritis: Could Lipocalin 2 Biomarkers Help?

Rheumato
Early diagnosis and therapy in axial spondyloarthritis, axSpA, is known to reduce long-term morbidity. However, the time from symptom onset to diagnosis is typically delayed by several years, and this situation has not improved in recent years despite ...
Kenneth P. H. Pritzker, Arash Samari
doaj   +1 more source

Lipocalin-2 and iron trafficking in the tumor microenvironment

Pharmacological Research, 2017
Iron is an essential element for virtually all organisms. It facilitates cell proliferation and growth but also contributes to major hallmarks of cancer such as tumor initiation, growth, and metastasis. Often, iron handling of tumor cells is disturbed, with altered iron acquisition, efflux, and storage. Targeting perturbed iron metabolic pathways might
Michaela, Jung, Christina, Mertens, Rebekka, Bauer, Claudia, Rehwald, Bernhard, Brüne   +4 more
openaire   +2 more sources

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

The Effects of 8 Eight Weeks Resistance Versus Endurance Training on Lipocalin-2 level in Non-Athlete Male Students

Armaghane Danesh Bimonthly Journal, 2012
Background & aim: Lipocalin-2 is a novel adipokine which is highly expressed in adipose tissue s that closely link with obesity, insulin resistance and type 2 diabetes.
A Mohammadi Domiyeh, A Khajehlandi
doaj  

Lipocalin-2 as a diagnostic marker for the severity of acute cholangitis [PDF]

Al-Azhar International Medical Journal
Background: One of the most prevalent acute abdominal surgical complications is acute cholangitis, which has a death rate of over 50% according to previous reports.
Nabil Seif El-Deen, Abdemonem Barrak, Mohamed Alboraie, Mohammed Mohammed, Abdel-Aleem Elgendy   +4 more
doaj   +1 more source