Results 91 to 100 of about 39,706 (298)

What determines health-related quality of life among people living with HIV : an updated review of the literature [PDF]

, 2014
Background: As infection with the Human Immunodeficiency Virus (HIV) has evolved to a chronic disease, perceived health-related quality of life (HRQoL) is becoming a prominent and important patient-reported outcome measure in HIV care.
Degroote, Sophie, Vandijck, Dominique, Vogelaers, Dirk   +2 more
core   +2 more sources

Potential Impact of Parental Origin of Inheritance on the Clinical Presentation of Familial Partial Lipodystrophy Type 2 Syndrome

Clinical Endocrinology, EarlyView.
ABSTRACT Context Familial partial lipodystrophy type 2 (FPLD2) is a rare autosomal dominant disorder caused by pathogenic variants in the LMNA gene. The influence of parental inheritance on clinical presentation has not been fully explored. Objective To investigate the influence of maternal versus paternal inheritance of LMNA variants on the clinical ...
Donatella Gilio, Ozge Besci, Natália Rossin Guidorizzi, Merve Celik Guler, Ilgin Yildirim Simsir, Caterina Pelosini, Giovanni Ceccarini, Korcan Demir, Baris Akinci, Ferruccio Santini, ECLip (European Consortium of Lipodystrophy), Maria Cristina Foss‐Freitas, Elif A. Oral   +12 more
wiley   +1 more source

PTRF Confers Melanoma‐Acquired Drug Resistance Through the Upregulation of EGFR

Cell Proliferation, EarlyView.
The upregulation of PTRF, a critical caveolar component, and the concomitant increase in caveolae number potentiate cellular proliferation and survival pathways, thereby contributing to melanoma drug resistance. ABSTRACT Melanoma is the most serious type of skin cancer. About half of all melanomas have activating BRAF mutations.
Miao Wang, Ying Cao, Chengcheng Ren, Ke Wang, Yaxiang Wang, Xiaoying Wu, Jian Mao, Qian Liang, Qian Zhang, Hezhe Lu, Xiaowei Xu, Yu‐Sheng Cong   +11 more
wiley   +1 more source

Impaired expression of mitochondrial and adipogenic genes in adipose tissue from a patient with acquired partial lipodystrophy (Barraquer-Simons syndrome): a case report

Journal of Medical Case Reports, 2008
Introduction Acquired partial lipodystrophy or Barraquer-Simons syndrome is a rare form of progressive lipodystrophy. The etiopathogenesis of adipose tissue atrophy in these patients is unknown.
Guallar Jordi P, Rojas-Garcia Ricardo, Garcia-Arumi Elena, Domingo Joan C, Gallardo Eduardo, Andreu Antoni L, Domingo Pere, Illa Isabel, Giralt Marta, Villarroya Francesc   +9 more
doaj   +1 more source

Effectiveness of GLP‐1RA according to different type 2 diabetes phenotypes: A retrospective study

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Type 2 diabetes (T2D) is a heterogeneous disease, with varying pathogenetic mechanisms influencing treatment response. Glucagon‐like peptide‐1 receptor agonists (GLP‐1RA) offer clear metabolic benefits in T2D, but interindividual variability in response is observed.
Irene Caruso, Fiorella Giordano, Immacolata Ilaria Matichecchia, Ludovico Di Gioia, Sergio Di Molfetta, Angelo Cignarelli, Gian Pio Sorice, Annalisa Natalicchio, Luigi Laviola, Francesco Giorgino   +9 more
wiley   +1 more source

Lipodystrophy : focus on HIV Lipodystrophy [PDF]

, 2017
Lipodystrophy is a rare condition which can be inherited or acquired, localised or generalised. It is characterised by abnormal adipose tissue distribution and in some cases underlying metabolic derangement, including diabetes mellitus ...
Fenech, Manuel, Giordano Imbroll, Miriam, Gruppetta, Mark   +2 more
core  

Evaluation of subcutaneous proleukin (Interleukin-2) in a randomized international trial (ESPRIT): Geographical and gender differences in the baseline characteristics of participants [PDF]

, 2006
Background: ESPRIT, is a phase III, open-label, randomized, international clinical trial evaluating the effects of subcutaneous recombinant interleukin-2 (rIL-2) plus antiretroviral therapy (ART) versus ART alone on HIV-disease progression and death in ...
Arduino, R., Austin, D., ESPRIT Research Group, Knysz, B., Law, M. G., Lopez, J. C., Pereira, L. C., Pett, S. L., Pollack, S., Reiss, P., Tambussi, G., Wand, H., Writing Group   +12 more
core   +3 more sources

Glycaemic responses to metformin monotherapy by SNP clusters in patients with type 2 diabetes

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims This study retrospectively investigates the association between polygenic risk scores (PRS) derived from SNP clusters and glycaemic response to metformin in patients with newly diagnosed T2D. Materials and Methods Utilizing a dataset from the Taiwan Precision Medicine Initiative, we evaluated alterations in fasting glucose (FBG) and ...
Wayne Huey‐Herng Sheu, Chun‐Yi Lee, Yi‐Wen Wang, Cai‐Sian Liao, Tzu‐Hung Hsiao, Ken Suzuki, Konstantinos Hatzikotoulas, Andrew P. Morris, the Type 2 Diabetes Global Genetics Initiative, Yii‐Der Ida Chen, Jerome I. Rotter   +10 more
wiley   +1 more source

Primary care for diabetes in HIV-infected patients [PDF]

, 2007
Diabetes mellitus (DM) is a common disorder affecting individuals of all ages. Similar to general population, DM can also be seen in HIV infected cases.
Wiwanitkit, Viroj
core   +1 more source

Animal models of NASH: getting both pathology and metabolic context right [PDF]

, 2015
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of referral to liver clinics, and its progressive form, non-alcoholic steatohepatitis (NASH), can lead to cirrhosis and end-stage liver disease.
Larter, Claire Z., Yeh, Matthew M.
core   +1 more source