Results 11 to 20 of about 39,706 (298)
Children, 2022 Lipodystrophy is the most common dermatological complication in patients with diabetes on insulin therapy. Despite the high frequency of lipodystrophy, there are still several difficulties in giving advice about avoidance into practice among children and
Fortunato Lombardo +5 more
doaj +2 more sources
European lipodystrophy registry: background and structure
Orphanet Journal of Rare Diseases, 2020 Background Lipodystrophy syndromes comprise a group of extremely rare and heterogeneous diseases characterized by a selective loss of adipose tissue in the absence of nutritional deprivation or catabolic state. Because of the rarity of each lipodystrophy
Julia von Schnurbein +24 more
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Congenital lipodystrophy induces severe osteosclerosis [PDF]
PLoS Genetics, 2019 Berardinelli-Seip congenital generalized lipodystrophy is associated with increased bone mass suggesting that fat tissue regulates the skeleton. Because there is little mechanistic information regarding this issue, we generated "fat-free" (FF) mice ...
W. Zou +10 more
semanticscholar +3 more sources
JCRPE, 2020 Lipodystrophy is a heterogeneous group of disorders characterized by lack of body fat in characteristic patterns, which can be genetic or acquired. Lipodystrophy is associated with insulin resistance that can develop in childhood and adolescence, and ...
Samim Özen +2 more
doaj +2 more sources
Surplus fatty acid synthesis increases oxidative stress in adipocytes and induces lipodystrophy
Nature CommunicationsAdipocytes are the primary sites for fatty acid storage, but the synthesis rate of fatty acids is very low. The physiological significance of this phenomenon remains unclear.
Li Weng +21 more
doaj +2 more sources
F1000Research, 2019 Lipodystrophy is a disease characterized by a partial or total absence of adipose tissue leading to severe metabolic derangements including marked insulin resistance, type 2 diabetes, hypertriglyceridemia, and steatohepatitis.
Thiago Bruder-Nascimento +2 more
doaj +2 more sources
Endocrinology and Metabolism Clinics of North America, 2016 Lipodystrophies are heterogeneous disorders characterized by varying degrees of body fat loss and predisposition to insulin resistance and its metabolic complications. They are subclassified depending on degree of fat loss and whether the disorder is genetic or acquired. The two most common genetic varieties include congenital generalized lipodystrophy
Iram, Hussain, Abhimanyu, Garg
openaire +4 more sources
Recent developments in lipodystrophy
Current Opinion in Lipidology, 2019 Purpose of review Lipodystrophy syndromes have an estimated prevalence of 1.3–4.7 cases per million and as with other rare diseases conducting research can be challenging. The present review highlights recently published work that has provided insights into the field of non-HIV--associated lipodystrophy syndromes.
Audrey Melvin +4 more
openaire +5 more sources
Molecular and Cellular Bases of Lipodystrophy Syndromes
Frontiers in Endocrinology, 2022 Lipodystrophy syndromes are rare diseases originating from a generalized or partial loss of adipose tissue. Adipose tissue dysfunction results from heterogeneous genetic or acquired causes, but leads to similar metabolic complications with insulin ...
J. Zammouri +11 more
semanticscholar +1 more source
Autoantibodies to Perilipin-1 Define a Subset of Acquired Generalized Lipodystrophy.
Diabetes, 2022 Acquired lipodystrophy is often characterized as an idiopathic subtype of lipodystrophy. Despite suspicion of an immune-mediated pathology, biomarkers such as autoantibodies are generally lacking.
C. Mandel-Brehm +26 more
semanticscholar +1 more source