Results 11 to 20 of about 16,386 (158)

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Lipodystrophy Syndromes

Endocrinology and Metabolism Clinics of North America, 2016
Lipodystrophies are heterogeneous disorders characterized by varying degrees of body fat loss and predisposition to insulin resistance and its metabolic complications. They are subclassified depending on degree of fat loss and whether the disorder is genetic or acquired. The two most common genetic varieties include congenital generalized lipodystrophy
Iram, Hussain, Abhimanyu, Garg
openaire   +3 more sources

Treatment Options for Lipodystrophy in Children

Frontiers in Endocrinology, 2022
Lipodystrophy includes a heterogeneous group of rare diseases characterized by different amounts of adipose tissue loss and several metabolic complications, including hypertriglyceridemia, steatohepatitis and particularly insulin resistance, that may ...
Francesca Mainieri, Veronica Maria Tagi, Francesco Chiarelli   +2 more
doaj   +1 more source

European lipodystrophy registry: background and structure

Orphanet Journal of Rare Diseases, 2020
Background Lipodystrophy syndromes comprise a group of extremely rare and heterogeneous diseases characterized by a selective loss of adipose tissue in the absence of nutritional deprivation or catabolic state. Because of the rarity of each lipodystrophy
Julia von Schnurbein, Claire Adams, Baris Akinci, Giovanni Ceccarini, Maria Rosaria D’Apice, Alessandra Gambineri, Raoul C. M. Hennekam, Isabelle Jeru, Giovanna Lattanzi, Konstanze Miehle, Gabriele Nagel, Giuseppe Novelli, Ferruccio Santini, Ermelinda Santos Silva, David B. Savage, Paolo Sbraccia, Jannik Schaaf, Ekaterina Sorkina, George Tanteles, Marie-Christine Vantyghem, Camille Vatier, Corinne Vigouroux, Elena Vorona, David Araújo-Vilar, Martin Wabitsch   +24 more
doaj   +1 more source

The enigma of persistent hypertriglyceridemia: A case report

Clinical Case Reports, 2022
A patient with a history of Mandibular hypoplasia, Deafness, Progeroid Features Associated Lipodystrophy Syndrome (MDPL), familial lipodystrophy presented with hypertriglyceridemia induced pancreatitis with triglycerides in the 3000s.
Armaan Dhaliwal, Soumiya Ravi, Kanwal Bains, Anil Kumar Potharaju, Tasneem Shah   +4 more
doaj   +1 more source

Prevalence of Insulin Injection-induced Lipodystrophy and Associated Risk Factors in Children and Adolescents With Type 1 Diabetes Mellitus

Journal of Pediatrics Review, 2022
Background: Lipodystrophy is the most common complication of insulin injection that has not been studied yet in children with Type 1 Diabetes Mellitus (T1DM) in Isfahan.
Neda Mostofizadeh, Milad Najafi, Silva Hovsepian, Elham Hashemi Dehkordi, Nousin Rostampour, Mahin Hashemipour   +5 more
doaj  

Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy

Journal of Venomous Animals and Toxins including Tropical Diseases, 2007
The extensive use of Highly Active Antiretroviral Therapy (HAART) has transformed HIV infection into a chronic condition. Thus, metabolic alterations including lipodystrophy and dyslipidemia have been associated with the use of such medications.
L. C. R. Pontes-Cardoso, L. R. Souza, M. T. S. Peraçoli, P. C. M. Pereira   +3 more
doaj   +1 more source

Isolated Congenital Lower Limb Lipoatrophy: A Case Report and Literature Review

Plastic and Reconstructive Surgery, Global Open, 2023
Summary:. Lipoatrophy and lipodystrophy can often be used interchangeably in the literature. However, there are some key differences. Inflammation plays a preliminary role in subcutaneous adipose tissue (SAT) loss in lipoatrophy, whereas lipodystrophy ...
Abdullah M. Alhusain, MBBS, Osama A. Alrodiman, MBBS, Faisal A. Alfaqeeh, MBBS, Sami I. Alissa, MBBS, SB-Plast   +3 more
doaj   +1 more source

Lipodystrophies in Children [PDF]

Hormone Research in Paediatrics, 2022
<b><i>Background:</i></b> Lipodystrophy includes a wide group of diseases characterized by reduction, absence, or altered distribution of adipose tissue. Lipodystrophies are classified into generalized or partial, according to the fat distribution, and congenital or acquired, considering the etiology.
Francesca, Mainieri, Francesco, Chiarelli   +1 more
openaire   +2 more sources

Lipodystrophy defined by Fat Mass Ratio in HIV-infected patients is associated with a high prevalence of glucose disturbances and insulin resistance

BMC Infectious Diseases, 2012
Introduction Combined antiretroviral therapy (cART) in the treatment of HIV-1 infection has been associated with complications, including lipodystrophy, hyperlipidaemia, insulin resistance (IR) and diabetes.
Freitas Paula, Carvalho Davide, Santos Ana, Mesquita Joana, Matos Maria, Madureira Antonio, Martinez Esteban, Sarmento António, Medina José   +8 more
doaj   +1 more source