Results 21 to 30 of about 22,509 (201)

Respiratory chain dysfunction associated with multiple mitochondrial DNA deletions in antiretroviral therapy-related lipodystrophy. [PDF]

, 2013
Highly-active antiretroviral therapy (HAART) can induce a characteristic lipodystrophy syndrome characterized by peripheral fat wasting and central adiposity, usually associated with hyperlipidaemia and insulin resistance [1,2].
Cardellach, Francesc, Pedrol, Enric, Nunes Martínez, Virginia, Casademont i Pou, Jordi, Miró i Andreu, Òscar, Gómez, Montserrat   +5 more
core   +6 more sources

Efficacy and Safety of SGLT2 Inhibitors in Patients With Genetic Lipodystrophy: A Real-Life Experience From a National Reference Network. [PDF]

Diabetes Obes Metab
ABSTRACT Aim Lipodystrophy syndromes are rare diseases with metabolic and cardiovascular consequences. This study explores the metabolic and renal effects of sodium‐glucose cotransporter 2 inhibitors (SGLT2i) in patients with genetic lipodystrophy. Patients and Methods Patients with familial partial lipodystrophy (n = 57) or congenital generalised ...
Robert L, Belalem I, Vigouroux C, Dupuis H, Vantyghem MC, Simonson M, Nobecourt E, Mosbah H, Beliard S, Jellimann S, Janmaat S, Vatier C, Lamothe S.   +12 more
europepmc   +2 more sources

Circulating Levels of MiRNAs From 320 Family in Subjects With Lipodystrophy: Disclosing Novel Signatures of the Disease

Frontiers in Endocrinology, 2022
Lipodystrophy (LD) indicates a group of rare disorders, with generalized or partial loss of white adipose tissue (WAT) often associated with metabolic derangements.
Alessia Dattilo, Alessia Dattilo, Giovanni Ceccarini, Gaia Scabia, Gaia Scabia, Silvia Magno, Lara Quintino, Caterina Pelosini, Guido Salvetti, Roberto Cusano, Matteo Massidda, Lucia Montanelli, Donatella Gilio, Gianluca Gatti, Alessandro Giacomina, Mario Costa, Mario Costa, Ferruccio Santini, Margherita Maffei, Margherita Maffei   +19 more
doaj   +1 more source

Lipodystrophies in Children [PDF]

Hormone Research in Paediatrics, 2022
<b><i>Background:</i></b> Lipodystrophy includes a wide group of diseases characterized by reduction, absence, or altered distribution of adipose tissue. Lipodystrophies are classified into generalized or partial, according to the fat distribution, and congenital or acquired, considering the etiology.
Francesca, Mainieri, Francesco, Chiarelli   +1 more
openaire   +2 more sources

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Brachioplasty in ex-obese patients: proposed classification [PDF]

Revista Brasileira de Cirurgia Plástica, 2023
Introduction: Surgical treatment of morbid obesity has resulted in a greater demand for repairing procedures for sequelae caused by weight loss. Brachioplasty treats excess skin and localized lipodystrophy in the arm and armpit regions.
Rodrigo Pinto Gimenez, Erick Samuel Santos De Mello, Raphaela Silveira Amaral, Tatiani Cerioni Toth   +3 more
doaj   +1 more source

Genetic basis of Asian diabetes. [PDF]

J Diabetes Investig
ABSTRACT Recent genomic studies in Asian populations have advanced our understanding of the diagnosis, pathophysiology, risk prediction, and precision care of diabetes. Monogenic diabetes, including maturity‐onset diabetes of the young (MODY) and mitochondrial diabetes, highlights the importance of genetic diagnosis for subtype‐specific care.
Ojima T, Yamauchi T.
europepmc   +2 more sources

Risk factors for diabetic foot ulcers in metreleptin naïve patients with lipodystrophy

Clinical Diabetes and Endocrinology, 2021
Aim Patients with lipodystrophy are at high risk for chronic complications of diabetes. Recently, we have reported 18 diabetic foot ulcer episodes in 9 subjects with lipodystrophy.
O Saydam, B Ozgen Saydam, SC Adiyaman, M Sonmez Ince, MA Eren, FE Keskin, H Bilen, M Dagdeviren, S Kaya, G Akinci, A Balci, C Altay, F Bayraktar, EA Oral, B Akinci   +14 more
doaj   +1 more source

Magnetic resonance spectroscopy to assess hepatic steatosis in patients with lipodystrophy

The Turkish Journal of Gastroenterology, 2020
Background/Aims: Lipodystrophy is a rare metabolic disorder characterized by near total or partial lack of subcutaneous adipose tissue and associated with insulin resistance.
Canan Altay, Mustafa Seçil, Süleyman Cem Adıyaman, Başak Özgen Saydam, Tevfik Demir, Gülçin Akıncı, Ilgın Yıldırım Simsir, Erdal Eren, Ela Temeloğlu Keskin, Leyla Demir, Hüseyin Onay, Haluk Topaloğlu, Banu Sarer Yürekli, Nilüfer Özdemir Kutbay, Ramazan Gen, Barış Akıncı   +15 more
doaj   +1 more source

Genetics of Lipodystrophy [PDF]

Endocrinology and Metabolism Clinics of North America, 2017
Lipodystrophy disorders are characterized by selective loss of fat tissue with metabolic complications including insulin resistance, hypertriglyceridemia, and nonalcoholic liver disease. These complications can be life-threatening, affect quality of life, and result in increased health care costs.
Marissa, Lightbourne, Rebecca J, Brown
openaire   +2 more sources