Results 21 to 30 of about 16,386 (158)

Lipodystrophy among HIV-Infected Patients Attending Care and Treatment Clinics in Dar es Salaam

AIDS Research and Treatment, 2017
Background. HIV infection and long-term HAART use are associated with metabolic and morphological changes. We assessed prevalence, types, and risk factors associated with lipodystrophy among HIV-infected adults attending CTC in Dar es Salaam, Tanzania ...
Marina Njelekela, Rose Mpembeni, Alfa Muhihi, Nzovu Ulenga, Eric Aris, Deodatus Kakoko   +5 more
doaj   +1 more source

The common pathophysiologic threads between Asian Indian diabetic’s ‘Thin Fat Phenotype’ and partial lipodystrophy: the peripheral adipose tissue transcriptomic evidences

Adipocyte, 2020
T2D is a complex disease with poorly understood mechanisms. In Asian Indians, it is associated with “thin fat” phenotype which resembles with partial lipodystrophy. We hypothesized that disturbed expression of lipodystrophy genes might play a role in T2D
Aditya Saxena, Pradeep Tiwari, Nitin Wahi, Anshul Kumar, Sandeep Kumar Mathur   +4 more
doaj   +1 more source

The acromegaly lipodystrophy

Frontiers in Endocrinology, 2022
Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) are essential to normal growth, metabolism, and body composition, but in acromegaly, excesses of these hormones strikingly alter them.
Pamela U. Freda
doaj   +1 more source

Case Report: Familial partial lipodystrophy, description of novel and ultrarare variants with distinct phenotypic spectrum

Frontiers in Endocrinology
Familial partial lipodystrophy (FPLD) is a rare inherited disorder characterized by selective loss of subcutaneous fat and severe metabolic complications.
Silvia Magno, Caterina Pelosini, Melania Paoli, Donatella Gilio, Lavinia Palladino, Francesca Menconi, Andrea Barison, Giancarlo Todiere, Simona Ortori, Barbara Coco, Giordano Paolucci, Guido Salvetti, Maria Rita Sessa, Giovanni Ceccarini, Ferruccio Santini   +14 more
doaj   +1 more source

Lipodystrophy in HIV/AIDS patients with different levels of physical activity while on antiretroviral therapy

Revista da Sociedade Brasileira de Medicina Tropical, 2011
INTRODUCTION: Lipodystrophy is related to the use of highly active antiretroviral therapy (HAART) and can cause aesthetic stigma and increase the risk of developing cardiovascular diseases.
Aline Francielle Mota Segatto, Ismael Forte Freitas Junior, Vanessa Ribeiro dos Santos, Kelly Cristina Pinto Alves, Dulce Aparecida Barbosa, Alexandre Martins Portelinha Filho, Henrique Luiz Monteiro   +6 more
doaj   +1 more source

Visceral fat does not contribute to metabolic disease in lipodystrophy

Obesity Science & Practice, 2019
Summary Objectives Lipodystrophies are characterized by regional or generalized loss of adipose tissue and severe metabolic complications. The role of visceral adipose tissue (VAT) in the development of metabolic derangements in lipodystrophy is unknown.
N. Malandrino, J. C. Reynolds, R. J. Brychta, K. Y. Chen, S. Auh, A. M. Gharib, M. Startzell, E. K. Cochran, R. J. Brown   +8 more
doaj   +1 more source

Causes for the development of lipodystrophy among HIV and AIDS patients

RUDN Journal of Medicine, 2018
Today, about 35 million people worldwide are infected with HIV. These patients often develop lipid metabolism disorder called lipodystrophy syndrome. Various clinical features of lipodystrophy are peripheral fat loss in the lower limbs, face and buttocks
O V Azovtseva, M K Belous
doaj   +1 more source

Efficacy of multivitamin support following bariatric surgery in patients with obesity: a prospective observational study

Eating and Weight Disorders
Purpose Bariatric surgery (BS), an effective treatment for severe obesity and its comorbidities, may result in micronutrient and vitamin deficiencies.
Alessio Basolo, Susanna Bechi Genzano, Jacopo Vitti, Guido Salvetti, Donatella Gilio, Giovanni Ceccarini, Giovanna Scartabelli, Chita Lippi, Rosario Bellini, Rudi Mancini, Simone D’Imporzano, Carlo Moretto, Valentina Angeli, Daniela Troiani, Paola Fierabracci, Roberta Jaccheri, Alba Calderone, Anello M. Poma, Luca Chiovato, Giorgio Saponati, Ferruccio Santini   +20 more
doaj   +1 more source

Recent advances in understanding lipodystrophy: a focus on lipodystrophy-associated cardiovascular disease and potential effects of leptin therapy on cardiovascular function [version 1; peer review: 3 approved]

F1000Research, 2019
Lipodystrophy is a disease characterized by a partial or total absence of adipose tissue leading to severe metabolic derangements including marked insulin resistance, type 2 diabetes, hypertriglyceridemia, and steatohepatitis.
Thiago Bruder-Nascimento, Taylor C. Kress, Eric J. Belin de Chantemele   +2 more
doaj   +1 more source

Adipocyte‐Derived Exosomal miR‐5099 Mitigates M1 Macrophage Polarization and Adipose Inflammation via c‐Met/NF‐κB Axis to Improve Metabolic Health

Advanced Science, EarlyView.
Celastrol upregulates adipocyte‐derived exosomal miR‐5099, suppressing the macrophage c‐Met/NF‐κB axis to mitigate pro‐inflammatory M1 polarization and adipose inflammation. These miR‐5099‐enriched exosomes also act as endocrine signals targeting the liver, muscle, and adipocytes to significantly enhance systemic insulin sensitivity.
Ping Tang, Lixin Tai, Hongxia Xu, Dongliang Zhu, Jiajia Li, Hao Feng, Jinghui Cui, Shuhai Lin, Li‐jun Di, Li Wang   +9 more
wiley   +1 more source