Results 1 to 10 of about 17,237 (190)

Lipofuscin, lipofuscin-like pigments and autofluorescence

European Journal of Histochemistry, 2015
A brief overview is here provided on lipofuscin and lipofuscin-like substances, with particular reference to their biological significance as well as to their cellular origin and pathophysiological role.
Giovanni Di Guardo
exaly   +7 more sources

Lipofuscin accumulation in aging and neurodegeneration: a potential “timebomb” overlooked in Alzheimer’s disease [PDF]

Translational Neurodegeneration
Lipofuscin, a marker of aging, is the accumulation of autofluorescent granules within microglia and postmitotic cells such as neurons. Lipofuscin has traditionally been regarded as an inert byproduct of cellular degradation.
Godfried Dougnon, Hideaki Matsui
doaj   +2 more sources

Age, lipofuscin and melanin oxidation affect fundus near-infrared autofluorescence

EBioMedicine, 2019
Background: Fundus autofluorescence is a non-invasive imaging technique in ophthalmology. Conventionally, short-wavelength autofluorescence (SW-AF) is used for detection of lipofuscin, a byproduct of the visual cycle which accumulates with age or disease
Tatjana Taubitz, Antje Biesemeier, Sylvie Julien-Schraermeyer   +2 more
exaly   +3 more sources

Role of macrophages in age-related oxidative stress and lipofuscin accumulation in mice

Redox Biology, 2017
The age-related changes in the immune functions (immunosenescence) may be mediated by an increase of oxidative stress and damage affecting leukocytes.
Carmen Vida, Irene Martínez de Toda, Antonio Garrido   +2 more
exaly   +3 more sources

Mitochondrial contribution to lipofuscin formation

Redox Biology, 2017
Mitochondria have been in the focus of oxidative stress and aging research for decades due to their permanent production of ROS during the oxidative phosphorylation.
Jeannette König, Christiane Ott, Martín Hugo, Tobias Jung, Anne-Laure Bulteau, Tilman Grune, Annika Höhn   +6 more
doaj   +3 more sources

Histochemical characteristics and distribution of lipofuscin and polyglucosan bodies in the brain of dogs more than 10 years old [PDF]

Veterinarski Glasnik, 2021
The ageing process is accompanied by numerous changes in the brain of dogs, such as accumulation of amyloid, fibrosis of blood vessel walls and meninges, accumulation of lipofuscin, and the presence of polyglucosan bodies (PGBs), satellitosis and ...
Nešić Slađan, Vučićević Ivana, Marinković Darko, Kukolj Vladimir, Aničić Milan, Ristoski Trpe, Nikolić Sonja, Aleksić-Kovačević Sanja   +7 more
doaj   +1 more source

Protein-Mediated Carotenoid Delivery Suppresses the Photoinducible Oxidation of Lipofuscin in Retinal Pigment Epithelial Cells

Antioxidants, 2023
Lipofuscin of retinal pigment epithelium (RPE) cells is a complex heterogeneous system of chromophores which accumulates as granules during the cell’s lifespan.
Alexey N. Semenov, Eugene G. Maksimov, Anastasia M. Moysenovich, Marina A. Yakovleva, Georgy V. Tsoraev, Alla A. Ramonova, Evgeny A. Shirshin, Nikolai N. Sluchanko, Tatiana B. Feldman, Andrew B. Rubin, Mikhail P. Kirpichnikov, Mikhail A. Ostrovsky   +11 more
doaj   +1 more source

Patterns of lipofuscin accumulation in ganglionic nerve cells of superior cervical ganglion in humans [PDF]

Vojnosanitetski Pregled, 2008
Background/Aim. Considering available literature lipofuscin is a classical age pigment of postmitotic cells, and a consistently recognized phenomenon in humans and animals.
Živković Vladimir, Stefanović Natalija, Đurović-Filipović Tatjana, Pavlović Snežana, Stojanović Vesna, Bakić Mirjana, Kundalić Braca, Pavlović Miljana   +7 more
doaj   +1 more source

Lipofuscin, Its Origin, Properties, and Contribution to Retinal Fluorescence as a Potential Biomarker of Oxidative Damage to the Retina

Antioxidants, 2023
Lipofuscin accumulates with age as intracellular fluorescent granules originating from incomplete lysosomal digestion of phagocytosed and autophagocytosed material.
Małgorzata B. Różanowska
doaj   +1 more source

Bone marrow lipofuscin [PDF]

Journal of Clinical Pathology, 1972
Lipofuscins are commonly present in the macrophages of the marrow. In unstained preparations they may be confused with haemosiderin, but they are readily distinguished by fluorescence microscopy.In contrast to the belief that lipofuscins are a manifestation of senility, no age dependence has been demonstrated.Exceptionally large amounts have been found
K G, Clark, W M, Davidson
openaire   +2 more sources