Results 141 to 150 of about 17,237 (190)

Lipofuscin and lipofuscin-like substances

Chemistry and Physics of Lipids, 1987
Lipofuscin is defined as being a yellowish brown, lipid-rich, heterogeneous, cytoplasmic granular pigment emitting an intense yellow autofluorescence when excited with ultraviolet light, which accumulates in various tissues of animals during their aging.
M, Tsuchida, T, Miura, K, Aibara
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Lipofuscin in Cardiac Hypertrophy

Beiträge zur Pathologie, 1972
Summary Quantitative investigations on the lipofuscin content in human hearts from various weight classes should allow us to conclude whether or not a correlation exists between pigment content and the degree of cardiac hypertrophy. The investigations were performed on 7 μ thick tissue sections from 12 autopsied hearts, and included microscopic ...
W, Sandritter, B, Bierfreund, F, Pannen, C P, Adler   +3 more
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The melanins and lipofuscin

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1983
An overview of the melanins and lipofuscin is presented, taking an integrating account of their morphological relationships and chemical characteristics wherever possible. This has required inclusion of the ommochromes, the schlerotizing process, and consideration of related neurotransmitters. A number of questions are raised and commented upon.
M H, Hack, F M, Helmy
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Lipofuscin and transsynaptic degeneration

Virchows Archiv A Pathological Anatomy and Histology, 1978
The periodic acid Schiff reaction was applied to neurones in the Lateral Geniculate Body (L.G.B.) of a series of normal and blind patients over a wide age range. The quantity of the reaction product was determined as a measure of lipofuscin which was found to increase linearly with age in the L.G.B. neurones.
C L, Scholtz, A, Brown
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A2E and Lipofuscin

2015
Lipofuscin is highly fluorescent material, formed in several tissues but best studied in the eye. The accumulation of lipofuscin in the retinal pigment epithelium (RPE) is a hallmark of aging in the eye and has been implicated in various retinal degenerations, including age-related macular degeneration.
Rosalie K, Crouch, Yiannis, Koutalos, Masahiro, Kono, Kevin, Schey, Zsolt, Ablonczy   +4 more
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Lipofuscin and Macular Degeneration

Nutrition Reviews, 2003
The accumulation of the autofluorescent pigment lipofuscin in the retina that occurs with aging has been explained as a side effect of the visual cycle. It occurs when two molecules of all-trans-retinal condense with one molecule of phosphatidylethanolamine in the discs of the rod outer segments, and is followed by uptake into retinal pigment ...
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Lipofuscin in human tongue muscle

Journal of Oral Pathology & Medicine, 1979
Abstract In a study of 107 tongue specimens lipofuscin granules were found to be present in the Muscle fibers of 93 % of the cases. The pigment was not found in young individuals under the age of 18 years. The pigmented granules, which were stored in clusters of different sizes at the nuclear poles, were PAS‐positive, stained black or brown with the ...
D, Dayan, R, David, A, Buchner
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Quantification of age pigments (lipofuscin)

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1988
1. Three methods have hitherto been applied for age pigment quantification: (a) numerically from micrographs; (b) fluorimetrically from histological sections; (c) spectrofluorimetrically from dissolved age pigments. 2. The spectrofluorimetric method is at present the most commonly used technique for quantification of age pigments. 3.
C, Hammer, E, Braum
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Proteasome Inhibition Enhances Lipofuscin Formation

Annals of the New York Academy of Sciences, 2002
Abstract: Lipofuscin, a hallmark of aged nondividing cells, is an undegradable autofluorescent intralysosomal substance composed essentially of oxidized, cross‐linked proteins. To test whether impaired activity of proteasomes—which, along with lysosomes, belong to major cellular proteolytic systems—may contribute to lipofuscinogenesis, we exposed ...
Alexei, Terman, Sara, Sandberg
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Mitochondrial Lipofuscin and Thermomitochondrial Lipofuscin in Homogenates of Rat Organs

Biophysics, 2019
Abstract—The amounts of lipofuscin (age pigment) were compared in four organs of rats: the liver, the kidney, the heart muscle, and the brain, as well as in a suspension of ghosts of hepatic mitochondria. It was shown that liver lipofuscin, which absorbs UV light at 360 nm and fluoresces at 460 nm, is predominantly formed due to mitochondrial processes.
A. V. Chaplygina, N. L. Vekshin
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