Preliminary identification and quantification of the age-pigment lipofuscin in the brain of Farfantepenaeus paulensis (Crustacea: Decapoda) [PDF]
Brazilian Journal of Biology, 2002 A preliminary study was done on the age-pigment lipofuscin content in the brains of captive Farfantepenaeus paulensis juveniles (5 months old) and wild adults (estimated age of 12-15 months). Random samples of 6 individuals were obtained from each group (
S. Peixoto +4 more
doaj +1 more source
ShenQi DiHuang Decoction (SQDHD) Ameliorates Neuroinflammation and Neuropsychiatric Manifestations in Pristane Induced Lupus Mice via Blocking JAK1-STAT3 Pathway. [PDF]
CNS Neurosci TherSQDHD exerts neuroprotective effects and alleviates behavioral deficits in PIL mice, likely by inhibiting the JAK1‐STAT3 pathway in activated CVECs. These findings underscore the therapeutic potential of SQDHD and establish it as a promising candidate for the treatment of NPSLE.
Chen J +9 more
europepmc +2 more sources
Scientific Reports, 2021 Melanosomes, lipofuscin, and melanolipofuscin are the three principal types of pigmented granules found in retinal pigment epithelium (RPE) cells. Changes in the density of melanosomes and lipofuscin in RPE cells are considered hallmarks of various ...
Ratheesh K. Meleppat +5 more
doaj +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
The 5HT1a receptor agonist 8-Oh DPAT induces protection from lipofuscin accumulation and oxidative stress in the retinal pigment epithelium. [PDF]
PLoS ONE, 2012 Age-related macular degeneration (AMD), a major cause of blindness in the elderly, is associated with oxidative stress, lipofuscin accumulation and retinal degeneration.
Prajitha Thampi +10 more
doaj +1 more source
Frontal lobe epilepsy with focal neuronal lipofuscinosis – Case report of a rare entity
Epilepsy & Behavior Reports, 2020 Focal neuronal lipofuscinosis is a unique neuronal pathology, characterised by accumulation of lipofuscin within dysmorphic neurons. We report a case of 12-year-old female with drug resistant epilepsy since one and a half years of age.
Radhika Mhatre +5 more
doaj +1 more source
Diagnostics, 2023 Age-related macular degeneration (AMD) may be associated with ABCA4 variants and is characterized by the accumulation of visual cycle-byproduct lipofuscin.
Hung-Da Chou +9 more
doaj +1 more source
Lipofuscin Hypothesis of Alzheimer’s Disease [PDF]
Dementia and Geriatric Cognitive Disorders Extra, 2011 The primary culprit responsible for Alzheimer’s disease (AD) remains unknown. Aβ protein has been identified as the main component of amyloid of senile plaques, the hallmark lesion of AD, but it is not definitively established whether the formation of extracellular Aβ deposits is the absolute harbinger of the series of pathological events that hit the ...
Giorgio Giaccone +3 more
openaire +3 more sources
Autofluorescence in freshly isolated adult human liver sinusoidal cells
European Journal of Histochemistry, 2021 Autofluorescent granules of various sizes were observed in primary human liver endothelial cells (LSECs) upon laser irradiation using a wide range of wavelengths.
Anett Kristin Larsen +7 more
doaj +1 more source
Retinal Pigment Epithelium Lipofuscin Proteomics [PDF]
Molecular & Cellular Proteomics, 2008 Lipofuscin accumulates with age in the retinal pigment epithelium (RPE) in discrete granular organelles and may contribute to age-related macular degeneration. Because previous studies suggest that lipofuscin contains protein that may impact pathogenic mechanisms, we pursued proteomics analysis of lipofuscin.
Kwok-Peng, Ng +14 more
openaire +2 more sources