Results 71 to 80 of about 17,237 (190)

Detection of Alloxan induced Lipofuscin pigmentation in the cells of renal tubule of diabetic rats

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2000
Objective: Diabetes mellitus is a metabolic disease due to failure in insulin secretion function. Kidney is a target organ in diabetes. Diabetic nephropathy is a major cause of end stage renal disease and resulting in increased morbidity and mortality of
M Pour Ghasem, M Jalali, M Nikravesh, M Behnam Rasoli, N Aminian   +4 more
doaj  

Ciliary Defects in Inherited Retinal Diseases

Advanced Genetics, Volume 7, Issue 1, March 2026.
The photoreceptor cilium is a specialized sensory organelle essential for vision. This review systematically summarizes the structural and functional defects of the cilium that lead to inherited retinal diseases (IRDs). It highlights key pathogenic genes, elucidates molecular mechanisms of degeneration, and evaluates emerging therapeutic strategies ...
Guizhi Guo, Lin Li, Jun Zhou, Jie Ran
wiley   +1 more source

Effect of ocular magnification on macular measurements made using spectral domain optical coherence tomography

Indian Journal of Ophthalmology, 2015
Aim: The aim of the present study was to study the effect of ocular magnification on macular measurements made using spectral domain optical coherence tomography (OCT).
Mohana Kuppuswamy Parthasarathy, Muna Bhende   +1 more
doaj   +1 more source

Age and Maturation Stage Linked Consequences of Fibrinogen on Human Oligodendroglia

Journal of Neuroscience Research, Volume 104, Issue 3, March 2026.
This study shows that the blood‐derived molecule, Fibrinogen, has a differential effect on human Oligodendroglial (OL) cells. Fibrinogen, when added in vitro, leads to aberrant differentiation of OL‐precursors towards an astrocytic fate. On the other hand, when added into the culture of mature OLs, fibrinogen increases myelination capacity.
Gabriela J. Blaszczyk, Chao Weng, Abdulshakour Mohammadnia, Qiao‐Ling Cui, Arianna Giurleo, Adam M. R. Groh, Chloe Plouffe, Julien Sirois, Valerio E. C. Piscopo, Moein Yaqubi, Asad Taqvi, Erin Cassidy, Liam Callahan Martin, Jeffery A. Hall, Roy W. R. Dudley, Myriam Srour, Stephanie E. J. Zandee, Wendy Klement, Sandra Larouche, Alexandre Prat, Thomas M. Durcan, Jo Anne Stratton, Jack P. Antel, G. R. Wayne Moore   +23 more
wiley   +1 more source

Lighting Up the Retina: Fundus Autofluorescence Imaging in Retinal and Choroidal Diseases

TNOA Journal of Ophthalmic Science and Research
Fundus autofluorescence (FAF) is a non-invasive imaging method that maps normal and abnormal retinal fluorophores, mainly lipofuscin. Although researched for decades, its major clinical use expanded significantly only in recent years. It has emerged as a
Kushal Delhiwala, Keshavi Shah
doaj   +1 more source

Noninvasive 11.7‐T Magnetic Resonance Spectroscopy and Imaging Reveals Retinal Metabolic Alterations Induced by Blue Light Exposure

NMR in Biomedicine, Volume 39, Issue 3, March 2026.
Retinal metabolic changes were analyzed using proton magnetic resonance spectroscopy (1H‐MRS), marking an initial application of this non‐invasive method on living eyes. Key metabolites were identified within the retinal region of adult rats. The observed changes following intense blue light exposure were predominantly attributable to the retina, as it
Lacramioara Samoila, Alexandru Farcasanu, Simion Simon, Ede Bodoki, Ovidiu Samoila, Oliviu Vostinaru, Elena Dinte, Andreea Elena Bodoki, Dan Iudean, Calin Muresan, Simona Clichici   +10 more
wiley   +1 more source

Glycative Stress Disrupts the Mitochondrial‐Lysosome Axis and Promotes Geroconversion in Aging Cardiomyocytes

Aging Cell, Volume 25, Issue 3, March 2026.
Cardiac aging promotes mitochondrial AGE accumulation driven by defective glycative stress detoxification. AGE‐modified mitochondria disrupt lysosomal proteolysis, impairing mitophagy and promoting lipofuscin buildup. This mechanism sustains chronic unresolved mitochondrial damage, driving proinflammatory senescence in cardiomyocytes and defining a ...
Diana Bou‐Teen, Simonas Valiuska, Elisabet Miro‐Casas, Chiara Rubeo, Elena Bonzon‐Kulichenko, Zuzana Nichtova, Celia Fernandez‐Sanz, Javier Inserte, Antonio Rodriguez‐Sinovas, Begoña Benito, Eduard Ródenas‐Alesina, Jesús Vázquez, Ignacio Ferreira‐González, Marisol Ruiz‐Meana   +13 more
wiley   +1 more source

Choroidal thickness changes after dynamic exercise as measured by spectral-domain optical coherence tomography

Indian Journal of Ophthalmology, 2015
Purpose: To measure the choroidal thickness (CT) after dynamic exercise by using enhanced depth imaging optical coherence tomography (EDI-OCT). Materials and Methods: A total of 19 healthy participants performed 10 min of low-impact, moderate-intensity ...
Nihat Sayin, Necip Kara, Gokhan Pekel, Hasan Altinkaynak   +3 more
doaj   +1 more source

Epidemiology of progressive intellectual and neurological deterioration in UK children

Developmental Medicine &Child Neurology, Volume 68, Issue 3, Page 418-428, March 2026.
This study of PIND in UK children was carried out via the British Paediatric Surveillance Unit from 1997 to 2024. It identified six cases of vCJD. 2367 children had other diagnoses explain their deterioration. There were 259 other diseases in the diagnosed group.
Christopher M. Verity, Polly J. Maunder, Anne Marie Winstone, Suvankar Pal   +3 more
wiley   +1 more source

An Overview of the Role of Lipofuscin in Age-Related Neurodegeneration

Frontiers in Neuroscience, 2018
Despite aging being by far the greatest risk factor for highly prevalent neurodegenerative disorders, the molecular underpinnings of age-related brain changes are still not well understood, particularly the transition from normal healthy brain aging to ...
Alexandra Moreno-García, Alejandra Kun, Alejandra Kun, Olga Calero, Olga Calero, Miguel Medina, Miguel Medina, Miguel Calero, Miguel Calero, Miguel Calero   +9 more
doaj   +1 more source