Results 201 to 210 of about 75,579 (341)

ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P

open access: yesCell, 2018
Ju Youn Kim   +8 more
semanticscholar   +1 more source

Inhibition of Hippo Signaling Through Ablation of Lats1 and Lats2 Protects Against Cognitive Decline in 5xFAD Mice via Increasing Neuronal Resilience Against Ferroptosis

open access: yesAging Cell, EarlyView.
5xFAD mice exhibited abnormal activation of Hippo signaling. Ablation of Lats1 and Lats2 in 5xFAD mice to inhibit Hippo signaling resulted in augmented cognition and ameliorated neurodegeneration, which were mediated by increased neuronal resilience against ferroptosis.
Robert C. Evans   +7 more
wiley   +1 more source

Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogenesis in mice

open access: gold, 2023
Nicole K.H. Yiew   +12 more
openalex   +1 more source

Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation

open access: yesDiabetes, 2015
G. den Besten   +10 more
semanticscholar   +1 more source

System level network data and models attack cancer drug resistance

open access: yesBritish Journal of Pharmacology, EarlyView.
Drug resistance is responsible for >90% of cancer related deaths. Cancer drug resistance is a system level network phenomenon covering the entire cell. Small‐scale interactomes and signalling network models of drug resistance guide directed drug development.
Márk Kerestély   +6 more
wiley   +1 more source

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