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Diversification of Lipopeptide Analogues Drives Versatility in Biological Activities. [PDF]

open access: yesJ Agric Food Chem
Grifé-Ruiz M   +4 more
europepmc   +1 more source
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Microbial lipopeptides: Properties, mechanics and engineering for novel lipopeptides

Microbiological Research, 2023
Microorganisms produce active surface agents called lipopeptides (LPs) which are amphiphilic in nature. They are cyclic or linear compounds and are predominantly isolated from Bacillus and Pseudomonas species. LPs show antimicrobial activity towards various plant pathogens and act by inhibiting the growth of these organisms.
Smitha Mony Sreedharan   +2 more
openaire   +2 more sources

Self-Adjuvanting Lipopeptide Vaccines

Current Medicinal Chemistry, 2008
Despite the important role of adjuvants for vaccine development, relatively few adjuvants have been successfully incorporated into vaccines intended for human administration. This is in part due to the high toxicity associated with many experimental adjuvants. This lack of choice effectively hinders the ability to produce vaccines against many diseases,
Moyle, P.M., Toth, I.
openaire   +3 more sources

Lipopeptide Pepducins as Therapeutic Agents

2021
Pepducins are lipidated peptides that target the intracellular loops of G protein-coupled receptors (GPCRs) in order to modulate transmembrane signaling to internally located effectors. With a wide array of potential activities ranging from partial, biased, or full agonism to antagonism, pepducins represent a versatile class of compounds that can be ...
Emily, Michael   +2 more
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Lipopeptide adjuvants in combination treatment

International Immunopharmacology, 2003
Synthetic lipopeptides derived from the N-terminus of bacterial lipoprotein constitute potent immunoadjuvants for parenteral and mucosal immunization. When combined with tetanus toxoid (TT) or gliadin as antigens, the lipopeptide N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-(R)-cysteinyl-seryl-(lysyl)(3)-lysine (P(3)CSK(4)) markedly enhanced the ...
Bessler, Wolfgang G.   +3 more
openaire   +3 more sources

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