Results 191 to 200 of about 16,028 (215)
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Synthesis of Lipopeptides by CLipPA Chemistry
2021Lipidation of polypeptides with a fatty acid to form N-linked lipopeptides can be a time consuming process due to the need to mask other reactive function groups present on the side chains of amino acids. Cysteine Lipidation on a Peptide or Amino acid (CLipPA) technology enables the direct lipidation of unprotected peptides containing a free thiol ...
Victor, Yim +3 more
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Structure elucidation of bacterial nonribosomal lipopeptides
Organic & Biomolecular Chemistry, 2020We provide a summary of the tools, which allow elucidate the structures of nonribosomal lipopetides.
Sebastian Götze, Pierre Stallforth
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Structure–Activity Relationships of Daptomycin Lipopeptides
Journal of Medicinal Chemistry, 2020Daptomycin is a calcium-dependent cyclic lipodepsipeptide derived from the soil saprotroph Streptomyces roseosporus, and its antibiotic properties make it a key agent for treatment of drug-resistant Gram-positive infections. It is most commonly used clinically for the treatment of Gram-positive skin and skin structure infections (SSSI), Staphylococcus ...
John A. Karas +8 more
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Novel dendrimeric lipopeptides with antifungal activity
Bioorganic & Medicinal Chemistry Letters, 2012A series of new cationic lipopeptides containing branched, amphiphilic polar head derived from (Lys)Lys(Lys) dendron and C(8) or C(12) chain at C-end were designed, synthesized and characterized. Antimicrobial in vitro activity expressed as minimal inhibitory concentration (MIC) was evaluated against Gram-positive and Gram-negative bacteria and yeasts ...
Jolanta, Janiszewska +6 more
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The Cyclic Lipopeptide Antibiotics
2017The cyclic lipopeptides comprise a number of clinically relevant classes of antibiotics that date back from the discovery of the polymyxins in 1947 to the recent introduction of the semi-synthetic lipoglycopeptides. These natural products and natural product derivatives most often originate from soil-inhabiting and/or plant-derived producing organisms.
Laurens H. J. Kleijn +1 more
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Biophysical studies of lipopeptide‐membrane interactions
Biopolymers, 1997There are a number of naturally occurring motifs for lipidation of peptides and proteins. In cases in which this involves adding a single hydrocarbon chain to the peptide, it is either a fatty acid or an isoprenyl group. Lipopeptides will partition between membrane and aqueous phases.
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Cyclic Lipopeptide Antibiotics
2008Abstract Numerous natural products have been discovered, mainly from microorganisms, algae and plants, that often exhibit interesting and useful biological activities. Of these, cyclic lipopeptide antibiotics form the biggest group and provide several clinically important drugs.
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Daptomycin: A novel cyclic lipopeptide antimicrobial
American Journal of Health-System Pharmacy, 2005The development, activity, pharmacokinetics, pharmacodynamics, clinical efficacy, adverse effects, and dosage and administration of daptomycin are reviewed.Daptomycin, a novel cyclic lipopeptide antimicrobial, is bactericidal against a range of gram-positive bacteria, including many multiple-drug-resistant isolates. It has only minimal activity against
Christopher A, Schriever +3 more
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Glycopeptides, Lipopeptides, and Lipoglycopeptides
2011Due to increasing resistance in Gram-positive organisms, use of glycopeptides, lipopeptides, and lipoglycopeptides will steadily increase. These three classes of drugs are primarily renally eliminated; therefore, CYP 450 interactions are not of concern.
Mary A. Ullman, John C. Rotschafer
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