Results 181 to 190 of about 6,907 (199)
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Clinica Chimica Acta, 2020
Atherosclerosis results from the excessive accumulation of lipids within the arterial wall. Lipophagy, referred to as the autophagic degradation of lipids, is a critical mechanism that regulates lipid metabolism in numerous cell types. The contribution of lipophagy to intracellular lipid turnover makes it a major player in the development and ...
Qing, Liu, Yuan-Mei, Wang, Hong-Feng, Gu
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Atherosclerosis results from the excessive accumulation of lipids within the arterial wall. Lipophagy, referred to as the autophagic degradation of lipids, is a critical mechanism that regulates lipid metabolism in numerous cell types. The contribution of lipophagy to intracellular lipid turnover makes it a major player in the development and ...
Qing, Liu, Yuan-Mei, Wang, Hong-Feng, Gu
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The N-degron pathway mediates lipophagy: The chemical modulation of lipophagy in obesity and NAFLD
Metabolism, 2023Central to the pathogenesis of nonalcoholic fatty liver disease (NAFLD) is the accumulation of lipids in the liver and various fat tissues. We aimed to elucidate the mechanisms by which lipid droplets (LDs) in the liver and adipocytes are degraded by the autophagy-lysosome system and develop therapeutic means to modulate lipophagy, i.e., autophagic ...
Eui Jung Jung +13 more
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Lipophagy: a new player in CNS disorders
Trends in Endocrinology & Metabolism, 2021Lipophagy is the process of selective degradation of lipid droplets (LDs) by autophagy. Several studies have highlighted the importance of lipophagy in regulating cellular lipid levels in various tissues and disease conditions. In recent years, disruption of autophagy and accumulation of LDs have been reported as pathological hallmarks in several ...
Mansour, Haidar +3 more
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A spartin approach to lipophagy
Science Signaling, 2023The autophagic degradation of lipid droplets requires the protein spartin.
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Emerging role of lipophagy in liver disorders
Molecular and Cellular Biochemistry, 2023Lipophagy is a selective degradation of lipids by a lysosomal-mediated pathway, and dysregulation of lipophagy is linked with the pathological hallmark of many liver diseases. Downregulation of lipophagy in liver cells results in abnormal accumulation of LDs (Lipid droplets) in hepatocytes which is a characteristic feature of several liver pathologies ...
Bismillah Nazeer +9 more
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Lipophagy: A Potential Therapeutic Target for Diabetic Nephropathy
Current Medicinal Chemistry, 2023Abstract: Diabetic nephropathy (DN) is a serious complication of diabetes mellitus and one of the main causes of end-stage renal disease (ESRD). There are many factors causing the progression of DN. Lipid metabolism disorder is a common clinical manifestation of DN, and ectopic renal lipid deposition was recently proposed as a key factor promoting the
Ming, Yang +3 more
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Lipid storage and lipophagy regulates ferroptosis
Biochemical and Biophysical Research Communications, 2019The synthesis, storage, and degradation of lipids are highly regulated processes. Impaired lipid metabolism is implicated in inflammation and cell death. Although ferroptosis is a recently described form of regulated cell death driven by lipid peroxidation, the impact of lipid droplets on ferroptosis remains unidentified.
Yuansong Bai +9 more
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Visualization of lipophagy using a supramolecular FRET pair
Chemical Communications, 2021Host–guest interactions between rationally designed fluorescent probes enable the visualization of lipophagy in live cells.
Ara Lee +6 more
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Nobiletin mitigates NAFLD via lipophagy and inflammation
Food & Function, 2022Nobiletin was found to mitigate nonalcoholic fatty liver disease by enhancing TFEB-mediated lipophagy, alleviating NLRP3 inflammasome and modulating macrophages polarization.
Xushan Yang +4 more
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Lipid droplets, lipophagy, and beyond
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2016Lipids are essential components for life. Their various structural and physical properties influence diverse cellular processes and, thereby, human health. Lipids are not genetically encoded but are synthesized and modified by complex metabolic pathways, supplying energy, membranes, signaling molecules, and hormones to affect growth, physiology, and ...
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