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Methods to Measure Lipophagy in Yeast
2017Maintenance of cellular and organismal lipid homeostasis is critical for life, and any deviation from a balanced equilibrium between fat uptake and degradation may have deleterious consequences, resulting in severe lipid-associated disorders. Excess fat is typically stored in cytoplasmic organelles termed "lipid droplets" (LDs); to adjust for a ...
A, Cristobal-Sarramian +2 more
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C9orf72 knockdown alleviates hepatic insulin resistance by promoting lipophagy
Biochemical and Biophysical Research Communications, 2022Insulin resistance (IR) attributed by the deficiency of lipophagy, is an abnormal state of downregulation of insulin-mediated glucose uptake and use into the liver. Chromosome 9 open reading frame 72 (C9orf72) variously modulates autophagy. We investigated the role and the downstream pathway of C9orf72 in hepatic IR.
Xiaomin, Cang +9 more
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Lipophagy and Mitophagy in Renal Pathophysiology
NephronBackground: The lysosomal autophagic pathway plays a fundamental role in cellular and tissue homeostasis, and its deregulation is linked to human pathologies including kidney diseases. Autophagy can randomly degrade cytoplasmic components in a nonselective manner commonly referred to as bulk autophagy.
Nicolas, Dupont, Fabiola, Terzi
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Targeting lipophagy in macrophages improves repair in multiple sclerosis
Autophagy, 2022Foamy macrophages containing abundant intracellular myelin remnants are an important pathological hallmark of multiple sclerosis. Reducing the intracellular lipid burden in foamy macrophages is considered a promising therapeutic strategy to induce a phagocyte phenotype that promotes central nervous system repair.
HAIDAR, Mansour +9 more
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Shear stress turns on the primary cilium and lipophagy
Nature Cell Biology, 2020While the formation and concentration of urine are better understood, how kidney epithelial cells generate the energy to drive these functions has remained unclear. A study now reveals that shear stress originating from urinary flow is sensed by the primary cilia of cortical epithelial cells and stimulates lipolysis and oxidative metabolism.
Nuria Martinez-Lopez, Rajat Singh
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Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
Journal of Visualized ExperimentsMacroautophagy, commonly referred to as autophagy, is a highly conserved cellular process responsible for the degradation of cellular components. This process is particularly prominent under conditions such as fasting, cellular stress, organelle damage, cellular damage, or aging of cellular components.
Carolina, Lagos +3 more
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Lipophagy is essential for lipid metabolism in fish
Science Bulletin, 2018Jing, Wang +7 more
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