Results 111 to 120 of about 130,911 (332)
Synthesis of 9-O-arylated berberines via copper-catalyzed CAr–O coupling reactions
Beilstein Journal of Organic Chemistry, 2019 Berberine is a widely used antimicrobial agent in clinic. However, a high dosage is often required due to its low lipophilicity and bioavailability. The current study explores the structural modifications of berberines with potentially lipophilic aryl ...
Qiaoqiao Teng +5 more
doaj +1 more source
The influence of aliphatic fluorination on lipophilicity
, 2019 Lipophilicity is known to influence a wide range of ADMET (absorption, distribution, metabolism, excretion and toxicity) properties and is widely regarded as one of the most important parameters within drug discovery programs.
Jeffries, Benjamin, Francis Joseph
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Lipophilicity determination of pyrazine [PDF]
, 2007 Lipophilicity determination of pyrazine chalcone derivatives Degree paper Svatava Balíková Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Drug Control, Heyrovského 1203, Hradec Králové The ...
Balíková, Svatava
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Biolipid Film‐Fused Electrochemiluminescence for Multipurpose In Situ Bioassays
Advanced Science, EarlyView.An ECL‐emissive, membrane‐interactive scaffold was fabricated, and facilely fused with natural and non‐native phospholipids into multifactorial mimicries of cytomembranes and vesicles for in vitro representative membrane‐process probing. Such a biointerface‐based, state‐sensitive ECL paradigm not only pinpointed proximal phenomena, including channeling
Jialiang Chen +9 more
wiley +1 more source
Antibacterial and Herbicidal Activity of Ring-Substituted 2-Hydroxynaphthalene-1-carboxanilides
Molecules, 2013 In this study, a series of twenty-two ring-substituted 2-hydroxynaphthalene-1‑carboxanilides were prepared and characterized. Primary in vitro screening of the synthesized compounds was performed against Staphylococcus aureus, three methicillin-resistant
Katarina Kralova +14 more
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley +1 more source
Chromatographic and computational lipophilicity assessment of novel antibiofilm agents
, 2020 In this study, lipophilicity of five newly designed molecules with antibiofilm properties was estimated for the first time. The overall goal of lipophilicity evaluation in lead generation phase is to decrease the traditionally high attrition rates for ...
Otašević, Biljana +4 more
core +1 more source
The influence of a surfactant, linear alkylbenzene sulfonate, on the estrogenic response to a mixture of (xeno)estrogens in vitro and in vivo [PDF]
, 2009 This is the post-print version of the final paper published in Aquatic Toxicology. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting ...
Marcomini, A. +26 more
core +1 more source
Influence of Permeant Lipophilicity on Permeation Across Human Sclera
, 2010 Purpose The objectives of this study were to determine the effects of permeant lipophilicity on permeant uptake into and transport across human sclera for transscleral delivery.
He Wen +5 more
core +1 more source
Advanced Science, EarlyView.We report the development of biotinylated PEGylated bilirubin‐coated perfluoropentane (bt‐PEG‐BR@PFP) nanobubbles, a novel class of ROS‐activatable and dual‐modality contrast agents that amplify both ultrasound (US) and magnetic resonance imaging (MRI) signals in response to elevated ROS.
Wonsik Jung +6 more
wiley +1 more source