Results 131 to 140 of about 130,911 (332)

Correlations between the lipophilicity and the inhibitory activity of different substituted benzimidazoles [PDF]

Chemical Industry and Chemical Engineering Quarterly, 2009
2-Amino and 2-methylbenzimidazole derivatives were tested in vitro for their inhibitory activity against the bacteria Bacillus cereus. The minimum inhibitory concentration (MIC) was determined for all compounds.
DIJANA J. BARNA, SANJA O. PODUNAVAC-KUZMANOVIĆ, DRAGOLJUB D. CVETKOVIĆ   +2 more
doaj  

Molecular Umbrella Transport: Exceptions to the Classic Size/Lipophilicity Rule

, 2016
Molecular Umbrella Transport: Exceptions to the Classic Size/Lipophilicity ...
Steven L. Regen (1308348), Wen-Hua Chen (1461001), Mohamed Mehiri (2394733), Vaclav Janout (1308342)   +3 more
core   +1 more source

High‐Performance Prevascularized SHED‐Laden rGO@Hydrogel Achieves Optimized Diabetic Bone Defect Repair

Advanced Science, EarlyView.
A high‐performance 3D scaffold integrating rGO and SHEDs is developed to overcome impaired healing in diabetic bone defects. By driving extracellular matrix remodeling, rGO creates a pro‐angiogenic niche that significantly accelerates in vitro vascular network formation.
Can Zhang, Yiyuan Kang, Shulin Lai, Chunyi Wang, Guixin He, Kehui Jian, Suhan Yin, Xiner Tan, Xinru Zhou, Wenjing Liu, Fujian Zhao, Jia Liu, Longquan Shao   +12 more
wiley   +1 more source

A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance

Advanced Science, EarlyView.
A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang, Tao Huang, Yiming Hao, Gui‐Feng Huang, Yi‐Lang Yan, Xin Fang, Ying Chen, Xiao‐Long Wei, Wai‐Lun Man, Wen‐Xiu Ni   +9 more
wiley   +1 more source

The effect of lipophilicity on the antibacterial activity of some 1-benzylbenzimidazole derivatives [PDF]

Journal of the Serbian Chemical Society, 2008
In the present paper, the antibacterial activity of some 1-benzylbenzimidazole derivatives were evaluated against the Gram-negative bacteria Escherichia coli. The minimum inhibitory concentration was determined for all the compounds.
D. J. BARNA, D. D. CVETKOVIC, S. O. PODUNAVAC-KUZMANOVIC   +2 more
doaj  

Lipophilicity of Coarse-Grained Cholesterol Models

, 2020
The lipophilicity of cholesterol was investigated by using coarse-grained molecular dynamics and umbrella sampling. The previous coarse-grained cholesterol models in the literature are more hydrophobic than our model.
Felipe R. Souza, Franceline Reynaud, Andre S. Pimentel (1892650), Franceline Reynaud (2747209), Franccesca Fornasier, Lucas M. P. Souza, Felipe R. Souza (8430297), Lucas M. P. Souza (8430294), Andre S. Pimentel, Franccesca Fornasier (8430291)   +9 more
core   +1 more source

In Vivo Electrochemical Monitoring of Safinamide Pharmacokinetics in the Brain Explores Its Correlation With Vision‐Related Neuronal Activity

Advanced Science, EarlyView.
An electrochemical platform based on differential pulse amperometry enables real‐time, selective tracking of safinamide pharmacokinetics in the living brain with high spatiotemporal resolution. When integrated with electrophysiology, this approach reveals that drug‐induced suppression of vision‐related neuronal activity provides mechanistic insight ...
Xiaoke Nan, Chuqi Li, Qianhe Dai, Junlan Zhou, Lijiao Cao, Yuying Liu, Jinger Chen, Meiping Xiong, Yuhang Jiang, Xianchan Li   +9 more
wiley   +1 more source

Influence of flavonoids’ lipophilicity on platelet aggregation

, 2019
Flavonoids are natural polyphenolic compounds present in a wide spectrum of plants that have a beneficial effect on human health. In the context of cardiovascular diseases related to plaque and thrombus formation, flavonoids exhibit an antiaggregatory ...
ŽELJAN MALEŠ, JUKIĆ, IRENA, MALEŠ, ŽELJAN, Zadro Renata, IVANA BABIĆ, ZADRO, RENATA, BABIĆ, IVANA, Duka Ivan, MIRZA BOJIĆ, BOJIĆ, MIRZA, Gojčeta Koraljka, HRVOJE RIMAC, Jukić Irena, KORALJKA GOJČETA, RIMAC, HRVOJE, DUKA, IVAN, Bojić Mirza, IVAN DUKA, IRENA JUKIĆ, Rimac Hrvoje, GOJČETA, KORALJKA, RENATA ZADRO, Babić Ivana, Maleš Željan   +23 more
core   +1 more source

Photocatalytic Synthesis of Pentafluorosulfanyl Ketones, Acetals, and BCP Motifs Utilizing SF6

Advanced Science, EarlyView.
A photocatalytic single electron reduction strategy is reported for the activation and valorization of sulfur hexafluoride (SF6), a potent greenhouse gas. Under mild conditions, SF6 is reduced to generate pentafluorosulfanyl (SF5) radicals, enabling direct access to pentafluorosulfanyl ketones, acetals, and BCP motifs.
Chen‐Hui Jiang, Haoran Xu, Yi‐Gang Yang, Xuan Nie, Meng‐Meng Zheng, Yue Zhao, Ya‐Wen Zuo, Wei‐Ran Ren, Shan Zhu, Ruo‐Xing Jin, Xiao‐Song Xue, Xi‐Sheng Wang   +11 more
wiley   +1 more source

Diffusion‐Based Generative Model With Scaffold‐Hopping Strategy Yields Highly Potent Bioactive Molecules

Advanced Science, EarlyView.
SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang, Xiaoqing Gong, Shukai Gu, Jing Li, Bo Liu, Yanan Tian, Qianqian Zhang, Xiaojun Yao, Huanxiang Liu   +8 more
wiley   +1 more source