Results 151 to 160 of about 47,589 (249)

Comprehensive Chemometric and Chromatographic Investigation of Lipophilicity of Biologically Active Androstane-3-Oxime Derivatives Across Diverse UHPLC Systems. [PDF]

Pharmaceuticals (Basel)
Kovačević SZ, Karadžić Banjac MŽ, Podunavac-Kuzmanović SO, Anojčić JS, Ajduković JJ.   +4 more
europepmc   +1 more source

Linker Engineering in Stapled Peptides for Enhanced Membrane Permeability: Screening and Optimization Strategies. [PDF]

Int J Mol Sci
Zhao M, Li B, Gao Y, Zhang R, Ahmattohti S, Li J, Shi X.   +6 more
europepmc   +1 more source

Investigations into linker effects of DNA-VHL ligand conjugates by multiplexed affinity measurements using focal molography. [PDF]

RSC Chem Biol
Raschke P, Notova S, Gatterdam V, Frutiger A, Brunschweiger A.   +4 more
europepmc   +1 more source

Evaluation of Oral PROTAC Guidelines: Efflux Ratio Outweighs Chameleonicity Descriptors. [PDF]

ACS Med Chem Lett
Le Manach C, Viklund J, Kwapień K, Winiwarter S.   +3 more
europepmc   +1 more source

In Silico Evaluation of 5-Arylidine Glitazone Esters as Potential Antidiabetic Agents: ADMET, Molecular Docking, Dynamics, MMGBSA and DFT Studies. [PDF]

Chem Biodivers
Mokgopa KP, Leoma MB, Tshiwawa T, Tshiluka NR.   +3 more
europepmc   +1 more source

Lipophilicity and bitter taste

Journal of Pharmacy and Pharmacology, 1978
openaire   +2 more sources

Structure-Activity Relationships of <i>closo</i>- and <i>nido</i>-Carborane Erlotinib Analogs: Lipophilicity as a Key Modulator of Anti-Glioma Activity. [PDF]

Pharmaceuticals (Basel)
Dávila B, Vignolo P, Silvarrey M, Benítez A, González Schmidt J, de Arteaga Guidotti C, García MF, Cerecetto H, Couto M.   +8 more
europepmc   +1 more source

Synthesis and Activity‐Based Protein Profiling Identifies Aldo‐Keto Reductase 1C3 as Target Protein of Myxoglucamides

Angewandte Chemie International Edition, EarlyView.
Myxoglucamide A—a novel glycolipopeptide isolated from myxobacteria—was synthesized, and activity‐based protein profiling identified aldo‐keto reductase 1C3 (AKR1C3) as its main target in human cells. Structure‐activity relationship studies, together with biophysical characterization and X‐ray crystallography, elucidated the structural basis of AKR1C3 ...
Thomas Siemon, Vivek K. Mishra, Mingming Zhao, Konrad Büssow, Alexander Popoff, Chengzhang Fu, Rolf Müller, Lothar Jänsch, Wulf Blankenfeldt, Mark Brönstrup   +9 more
wiley   +1 more source

Circular Photocaged mRNA for Light‐induced Late‐stage Activation of Translation

Angewandte Chemie International Edition, EarlyView.
A clickable photo‐caged 5′ cap (CyCliCap) allows to make Cyclic Click Cap‐containing mRNA (CyCliCap‐mRNA) which is remarkably stable and translationally muted until irradiated, allowing for late‐stage activation of translation in cells by light. ABSTRACT mRNA is a new medical modality as vaccine and raises hopes to become a protein replacement agent ...
Bayram Terzi, Greta Charlotte Dahm, Kristoffer Heintz, Martin Sumser, Yasuaki Kimura, Hiroshi Abe, Andrea Rentmeister   +6 more
wiley   +1 more source

Enzymatic Modification of Flavonoids: Implications for Bioavailability, Bioactivity, and Therapeutic Potential Based on a Systematic Review and Bioinformatics Analysis. [PDF]

Antioxidants (Basel)
Cunha MCD, Cunha MCD, Ferrari YBS, de Melo NC, Carvalho LM, Ortega MM, Carvalho PO.   +6 more
europepmc   +1 more source