Results 141 to 150 of about 47,589 (249)

Structural insights into the binding mode of the hypnotic drug vornorexant to orexin receptors. [PDF]

Acta Crystallogr F Struct Biol Commun
Mima M, Mishima-Tsumagari C, Sakata-Sakuta M, Iwaoka R, Iwamoto K.   +4 more
europepmc   +1 more source

Remapping the Synthetic Landscape of α‐Tertiary Alkylamines via Dual‐Functional Catechol

Angewandte Chemie, EarlyView.
A three‐component assembly strategy has been developed for the modular synthesis of hindered α‐tertiary aliphatic amines from readily available precursors through unlocking the dual role of catechol. The practicality of this methodology has been demonstrated in over 90 examples, including compounds that are otherwise difficult to access, along with ...
Chen‐Yan Cai, Yuzuru Kanda, Tian Qin
wiley   +2 more sources

Phosphoramidate Derivatives of Betulin, New Molecules with Promising Biological Activity: Synthesis and Characterization. [PDF]

Molecules
Chrobak E, Świtalska M, Madej M, Wietrzyk J, Bębenek E.   +4 more
europepmc   +1 more source

The Biggest Challenge for Prediction of Membrane Permeability of Cyclic Peptides: Scarce Data Availability. [PDF]

J Med Chem
Lamers C.
europepmc   +1 more source

Biological and In Silico Evaluation of Novel Methoxyphenol-1,2,3-Triazole Hybrids as Multifunctional Anti-Alzheimer's and Anticancer Agents. [PDF]

Chem Biol Drug Des
Onur S, Çeşme M, Tümer F.
europepmc   +1 more source

Key contemporary considerations for halogens in drug discovery. [PDF]

Future Med Chem
Ali S, Zhou J.
europepmc   +1 more source

Unified Synthesis of Unconventional α‐Polyhalogenated Amines Through Hydroaminoalkylation

Angewandte Chemie International Edition, EarlyView.
A unified, redox‐neutral method that transforms alkenes and alkynes into α‐polyhalomethyl amines using stable hemiaminal reagents is reported. This approach enables access to CF3, CF2H, CF2Cl, and CFClH motifs, expanding halogenated amine space with broad substrate scope, functional group tolerance, and applicability to late‐stage modification of drug ...
Angela K. Hofmeister, Giulia Iannelli, Péter Angyal, Augustin Malandain, Daniel Kaiser, Boris Maryasin, Hanspeter Kählig, Matteo Barel, Gaia Novarino, Nuno Maulide   +9 more
wiley   +1 more source

Biomimetic Partitioning and Pharmacokinetic Insights into Phytocannabinoids. [PDF]

ACS Omega
Martin JK, Muensterman DJ, Droz B, Valko K, Truong L, Tanguay RL, Field JA.   +6 more
europepmc   +1 more source

Deciphering Molecular and Solvent Effects on Aqueous and Organic Solubility through Interpretable Machine Learning Approaches. [PDF]

ACS Omega
Gopichand B, Nair GS, Nair BG, Melethadathil N.   +3 more
europepmc   +1 more source

Discovery of a tetrazole-thiourea derivative as a potential active agent against multidrug-resistant Staphylococcus aureus and Mycobacterium tuberculosis. [PDF]

Pharmacol Rep
Szymańska-Majchrzak J, Głogowska A, Augustynowicz-Kopeć E, Greber KE, Ciura K, Olejarz W, Szostek T, Struga M, Szulczyk D.   +8 more
europepmc   +1 more source