Results 121 to 130 of about 50,842 (252)

Difluoromethylenation of Alkynes: Streamlined Access to Allyl Difluorides

Angewandte Chemie, EarlyView.
Stabilizing primary oxocarbenium in HF/pyridine unlocks a direct alkyne difluoromethylenation – an efficient route to synthetically‐relevant allyl difluorides in a single step. ABSTRACT A direct difluoromethylenation of alkynes has been developed using HF/pyridine as a dual acidic and fluorinating medium. The reaction proceeds via in situ generation of
Fabien Naullet, Sourav Mondal, Frédéric Guégan, Bastien Michelet, Sébastien Thibaudeau   +4 more
wiley   +2 more sources

Biomimetic Chromatography Profiling of a Neurotoxicology-Relevant Compound Panel: A Physicochemical Dataset for New Approach Methodologies. [PDF]

Biomimetics (Basel)
Nisterenko W, Singh YR, Greber KE, Jagiełło K, Ciura K.   +4 more
europepmc   +1 more source

Pt(iv) scaffold effects on nucleolar stress and DNA damage response pathways. [PDF]

RSC Chem Biol
Griffin CR, DeRose VJ.
europepmc   +1 more source

Clean Synthesis of N-4-Alkylamino-7-chloroquinoline Cyclic Imides: Influence of Lipophilicity on Antibacterial and Ecotoxicological Properties. [PDF]

Chem Biodivers
Luz-Filho AP, Silva TC, Silva MB, Sousa AP, Souza HDS, Lima PSV, Almeida-Júnior A, Sampaio FC, Athayde-Filho PF, Fiss GF.   +9 more
europepmc   +1 more source

Lipophilicity [PDF]

, 2020
openaire   +1 more source

Integral Lipophilicity Studies with in Silico ADMET Parameter Analysis of Novel Pseudothiohydantoin Derivatives. [PDF]

Int J Mol Sci
Baumgart S, Redka M, Słomka A, Studzińska R.   +3 more
europepmc   +1 more source

The Beekeeping Sector of Kazakhstan and Contributions to the Pharmaceutical Industry: Promising Flavonoids with the Pharmacokinetic Properties Via the Computational Evaluations. [PDF]

F1000Res
Kaya Ş, Selamoglu Z, Durna Daştan S, Gaipov T, Daştan T, Salybekova N.   +5 more
europepmc   +1 more source

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

Angewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

Do Brain Extracellular Fluid Concentrations Predict PET-Inferred Receptor Occupancy in Human CNS? A Mechanistic Model-Based Analysis of Dopamine D2 Receptor Ligands. [PDF]

Clin Pharmacol Ther
Budda D, van Hasselt JGC, de Lange ECM.
europepmc   +1 more source

Bicyclo[1.1.1]pentane as a Phenyl Isosteric Replacement. [PDF]

ACS Med Chem Lett
Saar A, Kombo DC, Thurairatnam S, Kothe M, Merriman G, Tsymbal AV, Kane JL, LaMarche MJ, Gkeka P, Li Y.   +9 more
europepmc   +1 more source