Results 31 to 40 of about 279,832 (297)
Frontiers in Pharmacology, 2020 Abnormal microglia activation causes sever neuroinflammation, contributing to the development of many diseases, yet the mechanism remains incompletely unknown.
Xiude Qin +10 more
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Frontiers in Animal Science, 2022 Uterine bacterial community abundances shift throughout the estrous cycle, potentially altering the immunological environment of the uterus and impacting subsequent fertility. The objective of the current study was to evaluate the immunological impact of
Taylor B. Ault-Seay +10 more
doaj +1 more source
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1999 Chlamydiae are obligatory intracellular parasites which are responsible for various acute and chronic diseases in animals and humans. The outer membrane of the chlamydial cell wall contains a truncated lipopolysaccharide (LPS) antigen, which harbors a group-specific epitope being composed of a trisaccharide of 3-deoxy-D-manno-oct-2-ulosonic (Kdo ...
openaire +2 more sources
Virulence factors of Aggregatibacter actinomycetemcomitans - A status update
Journal of International Clinical Dental Research Organization, 2015 Periodontitis is a chronic infectious inflammatory disease characterized by the destruction of tooth. The contribution of bacteria to the disease progression is poorly understood probably due to the multifactorial background of this disease ...
Rajvir Malik +4 more
doaj +1 more source
Frontiers in Pharmacology, 2016 Microvesicles, small membrane vesicles released from cells, have beneficial and/or deleterious effects in sepsis. We previously reported that non-muscle myosin light chain kinase (nmMLCK) deletion protects mice against endotoxic shock by reducing ...
Abderahim Gaceb +3 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Periodontitis is an inflammatory disease of gum that may predispose to serious systemic complications such as diabetes and cardiovascular diseases. Activation of macrophages and osteoclasts around periodontal tissue can accelerate gum inflammation.
Cheng-Hsiang Kuo +17 more
doaj +1 more source
TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation
FEBS Letters, EarlyView.TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling +4 more
wiley +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Fishes, 2017 Antimicrobial peptides (AMPS) are ancestral components in the evolution of immunity from protozoans to metazoans. Their expression can be constitutive or inducible by infectious challenge. Although characterized in detail in their structure and activity,
Elisabetta Caccia +5 more
doaj +1 more source
Effect of the Extracellular Vesicle RNA Cargo From Uropathogenic Escherichia coli on Bladder Cells
Frontiers in Molecular Biosciences, 2020 Iron restriction in mammals, part of innate antimicrobial defense, may be sensed as a signal by an infecting pathogen. Iron-dependent regulators not only activate the pathogen’s specific iron acquisition and storage mechanisms needed for survival but ...
Priscila Dauros-Singorenko +10 more
doaj +1 more source