Results 151 to 160 of about 24,826 (263)

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

open access: yesAdvanced Science, Volume 13, Issue 35, 24 June 2026.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen   +4 more
wiley   +1 more source

Impact of lipoprotein apheresis on Lipoprotein (a) levels: results from a high cardiovascular risk cohort at the clinical center of Padua

open access: yes
reservedPresupposti dello studio. Elevate concentrazioni plasmatiche di lipoproteina (a) [Lp(a)] costituiscono un determinante causale e indipendente di aterosclerosi e delle sue complicanze, con un incremento del rischio cardiovascolare clinicamente ...
SIVIERO, ANNA CATERINA
core  

Method Comparison of Dried Blood Spot and Plasma Apolipoprotein B Measurement on a Semi‐Automated Analyser: Toward Accessible Lipid Profiling in Resource‐Limited Settings

open access: yesAnalytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT Apolipoprotein B (ApoB) is a key marker of atherogenic lipoprotein burden, but conventional plasma‐based testing requires venous sampling and centralized laboratory infrastructure. Dried blood spot (DBS) sampling offers a minimally invasive alternative suitable for decentralized settings.
Bronwyn Pitampersad   +4 more
wiley   +1 more source

Association Between the Cholesterol–HDL–Glucose (CHG) Index and 90‐Day Functional Outcomes in Patients with Acute Ischemic Stroke

open access: yesBrain and Behavior, Volume 16, Issue 6, June 2026.
The CHG index, derived from total cholesterol, high‐density lipoprotein, and fasting blood glucose, was associated with 90‐day functional outcomes after acute ischemic stroke. ABSTRACT Background: Acute ischemic stroke (AIS) is a major cause of global disability and mortality.
Xinyue Yuan   +5 more
wiley   +1 more source

LncRNA MIR503HG serves as a diagnostic biomarker in patients with sepsis and regulates sepsis‐induced inflammation and cardiac dysfunction

open access: yesJournal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
MIR503HG was downregulated in sepsis and sepsis‐induced cardiac dysfunction (SICD) and served as a diagnostic biomarker. Overexpression of MIR503HG attenuated myocardial injury and systemic inflammation in a septic rat model. Mechanistically, MIR503HG acted as a ceRNA by sponging miR‐497‐5p to upregulate BDNF, revealing a protective MIR503HG/miR‐497‐5p/
Pingping Qi   +5 more
wiley   +1 more source

A Stacked Ensemble Multi‐Label Model for Predicting Co‐Occurring Microvascular and Macrovascular Complications in Type 2 Diabetes

open access: yesChronic Diseases and Translational Medicine, Volume 12, Issue 2, Page 151-160, June 2026.
Feature importance for predicting multiple diabetes complications based on a Stacking‐Classifier Chain model. ABSTRACT Background Type 2 diabetes mellitus (T2DM) leads to severe microvascular and macrovascular complications. Traditional single‐label prediction models fail to capture their co‐occurring nature.
Maryam Zamani   +3 more
wiley   +1 more source

LRP1 Activation Promotes Metabolic Reprogramming and Mrc1 Expression to Attenuate LPS‐Induced Cognitive Deficits: An Integrated Omics Analysis

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
LPS triggers neuroinflammation within the central nervous system. Conversely, the activation of LRP1 by SP16 mitigates insulin resistance, improves glucose metabolism, and facilitates the polarization of microglia toward an anti‐inflammatory M2‐like phenotype, which collectively contribute to the restoration of cognitive function.
Mengyao Qu   +9 more
wiley   +1 more source

Long‐term trends in metabolic profiles across Chinese birth cohorts: A real‐world big data analysis

open access: yesClinical and Translational Medicine, Volume 16, Issue 6, June 2026.
• Younger generations (1980s–1990s) exhibit higher fasting glucose and rebounding total cholesterol and low‐density lipoprotein cholesterol, alongside declining high‐density lipoprotein cholesterol and triglycerides compared to 1930s–1970s cohorts.
Ying Xiong   +7 more
wiley   +1 more source

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