Results 101 to 110 of about 28,679 (286)

Mechanisms of lipotoxicity in bone

, 2016
Interest in the interaction between fat and bone has increased recently. Two types of fat and bone connection have been described in the literature: systemic and local.
Gunaratnam, Krishanthi
core  

Magnesium isoglycyrrhizinate reduces hepatic lipotoxicity through regulating metabolic abnormalities

, 2021
The excessive accumulation of lipids in hepatocytes induces a type of cytotoxicity called hepatic lipotoxicity, which is a fundamental contributor to liver metabolic diseases (such as NAFLD).
Kun Hao, Zhu, Zheying, Jiang, Wenjiao, Jie Liu, Zhu, Jinwei, Wang, Guangji, Wenjiao Jiang, Hao, Kun, Hong, Yu, Zheying Zhu, Lu, Li, Liu, Jie, Yu Hong, Peng, Ying, Li Lu, Guangji Wang, Jinwei Zhu, Ying Peng   +17 more
core   +1 more source

Inadequate fat diet

Journal of Education, Health and Sport, 2020
Aim. To determine the main factors of inadequate fat diet (IAFD) and indicate the ways of their change.Methods. Analysis and generalization of existing scientific literature data and the results of our own research.Results.
A. P. Levitsky, B. V. Egorov, A. P. Lapinskaya, I. A. Selivanskaya   +3 more
doaj   +1 more source

Stevioside Counteracts Beta-Cell Lipotoxicity without Affecting Acetyl CoA Carboxylase.

, 2006
Chronic exposure to high levels of free fatty acids impairs beta-cell function (lipotoxicity). Then basal insulin secretion (BIS) is increased and glucose-stimulated insulin secretion (GSIS) is inhibited.
Jeppesen, Per Bendix, Nordentoft, Iver, Hermansen, Kjeld, Chen, Jianguo   +3 more
core   +1 more source

Renal lipid metabolism and lipotoxicity [PDF]

Current Opinion in Nephrology and Hypertension, 2010
Lipid accumulation in nonadipose tissues is increasingly recognized to contribute to organ injury through a process termed lipotoxicity, but whether this process occurs in the kidney is still uncertain. This article briefly summarizes the normal role of lipids in renal physiology and the current evidence linking excess lipids and lipotoxicity to renal ...
openaire   +2 more sources

Traditional Chinese Medicine and Natural Products Targeting Right Ventricular Dysfunction in Pulmonary Arterial Hypertension: Toward Precision Cardiometabolic Therapy

iNew Medicine, EarlyView.
Natural products and traditional Chinese medicine target metabolic pathways underlying right ventricular dysfunction in pulmonary arterial hypertension. Integrating multi‐omics, artificial intelligence, and systems biology may enable precision cardiometabolic therapies to restore right ventricular metabolism and improve clinical outcomes.
Yihao Wu, Zhehui Tang, Hongwei Yao
wiley   +1 more source

Identification of Lipotoxicity-Related Biomarkers in Diabetic Nephropathy Based on Bioinformatic Analysis

Journal of Diabetes Research
Conclusion: The identified lipotoxicity-related hub genes provide a deeper understanding of the development mechanisms of DN, potentially offering new theoretical foundations for the development of diagnostic biomarkers and therapeutic targets related to
Han Nie, Huan Yang, Lidan Cheng, Jianxin Yu   +3 more
doaj   +1 more source

Mechanistic Investigations of Lipotoxicity in Non-Alcoholic Fatty Liver Disease

, 2017
Lipotoxicity is regard as the central mechanism underlying Non-Alcoholic Fatty Liver Disease (NAFLD), however, the exact mechanism of lipotoxicity remains to be understood.
Chen Shen (415899)
core  

The Role of Lipotoxicity in Smoke Cardiomyopathy

PLoS ONE, 2014
Experimental and clinical studies have shown the direct toxic effects of cigarette smoke (CS) on the myocardium, independent of vascular effects. However, the underlying mechanisms are not well known.Wistar rats were allocated to control (C) and cigarette smoke (CS) groups.
Santos, Priscila P., Oliveira, Fernando, Ferreira, Vanessa C. M. P., Polegato, Bertha Furlan, Roscani, Meliza Goi, Fernandes, Ana Angelica, Modesto, Pamela, Rafacho, Bruna P. M., Zanati, Silmeia G., Di Lorenzo, Annarita, Matsubara, Luiz Shiguero, Paiva, Sergio Alberto Rupp de, Zornoff, Leonardo Antonio Mamede, Minicucci, Marcos Ferreira, Gaiolla, Paula Schmidt Azevedo   +14 more
openaire   +5 more sources

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source