Results 121 to 130 of about 28,679 (286)

The impact of cardiac lipotoxicity on cardiac function and mirnas signature in obese and non-obese rats with myocardial infarction [PDF]

, 2019
Cardiac lipotoxicity is involved in the cardiac functional consequences associated with obesity. Therefore, the aim of this study was to explore whether changes in the mitochondrial lipid cardiac profile could reflect differences in cardiac function and ...
Luaces, María, Nieto, María Luisa, Cachofeiro, Victoria, Martínez Martínez, Ernesto, Gómez-Garre, Dulcenombre, Marín-Royo, Gema, García-Bouza, Mónica, Ortega-Hernández, Adriana, Martínez-Martínez, Ernesto, Lagunas, Esther, Ramchandani, Bunty, Cachofeiro Ramos, María Victoria, Jurado-López, Raquel, Delgado-Valero, Beatriz, Islas, Fabián   +14 more
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Lipid and Foam Cell Accumulation as Novel Pathological Features of Benign Prostatic Hyperplasia

The Prostate, EarlyView.
ABSTRACT Background Benign prostatic hyperplasia (BPH) encompasses a heterogeneous set of pathological processes that instigate lower urinary tract symptoms (LUTS). Using a mouse model of steroid hormone imbalance–induced lower urinary tract dysfunction, we identified luminal lipid‐laden foamy macrophages, although their presence and contribution to ...
Dita Julianingsih, Samara V. Silver, Thaissa Horne, Kasun Gunawardena, Savannah Ward, Alicia Malewska, Douglas Strand, Julius Nyalwidhe, Ilya Sobol, Petra Popovics   +9 more
wiley   +1 more source

Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids

Excessive levels of saturated fatty acids are toxic to cells, although the basis for this lipotoxicity remains incompletely understood. Here, we analyzed the transcriptome, lipidome, and genetic interactions of human leukemia cells exposed to palmitate ...
Pulimeno, Pamela, Chitraju, Chandramohan, Elliott, Shane D., Piccolis, Manuele, Bond, Laura M., Vaites, Laura P., Harper, J. Wade, Gabriel, Katlyn R., Farese, Robert V., Jr., Jayson, Christina B. K., Kampmann, Martin, Boland, Sebastian, Lai, Zon Weng, Weissman, Jonathan S., Walther, Tobias C., Paulo, Joao A.   +15 more
core   +1 more source

Lipotoxicity in type 2 diabetic cardiomyopathy [PDF]

, 2011
As obesity and type 2 diabetes are becoming an epidemic in westernized countries, the incidence and prevalence of obesity- and diabetes-related co-morbidities are increasing.
Schrauwen, P., Schrauwen-Hinderling, V.B., Patrick Schrauwen, van de Weijer, T., Tineke van de Weijer, Vera B. Schrauwen-Hinderling   +5 more
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The Neuroprotective Effect of a Waste Byproduct Obtained From Pomegranate (Punica granatum)

Phytotherapy Research, EarlyView.
The Effect of a Waste Byproduct Obtained From Pomegranate on Neurodegeneration. ABSTRACT Pomegranate is an exceptional fruit that can have several beneficial effects on human health. The peel of pomegranate, a waste product, should be recovered as it still contains valuable constituents, including phenolic compounds, minerals and fibre. The recovery of
Jessica Maiuolo, Valeria Mazza, Rosamaria Caminiti, Francesca Oppedisano, Saverio Nucera, Salvatore Ragusa, Sara Ilari, Lucia Carmela Passacatini, Luigi Tucci, Giuseppe Trunfio, Vincenzo Mollace, Carolina Muscoli   +11 more
wiley   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Lipotoxicity of palmitic acid is associated with DGAT1 downregulation and abolished by PPARα activation in liver cells

Journal of Lipid Research
Lipotoxicity refers to the harmful effects of excess fatty acids on metabolic health, and it can vary depending on the type of fatty acids involved. Saturated and unsaturated fatty acids exhibit distinct effects, though the precise mechanisms behind ...
Camilla Moliterni, Francesco Vari, Emily Schifano, Stefano Tacconi, Eleonora Stanca, Marzia Friuli, Serena Longo, Maria Conte, Stefano Salvioli, Davide Gnocchi, Antonio Mazzocca, Daniela Uccelletti, Daniele Vergara, Luciana Dini, Anna Maria Giudetti   +14 more
doaj   +1 more source

PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes

British Journal of Pharmacology, EarlyView.
Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier, David Spähn, David Arturo Juarez Lopez, Judith L. Nono, Judith Seigner, Lisa Jacob, Siegfried Ussar, Robert Lukowski, Andreas L. Birkenfeld, Gencer Sancar   +9 more
wiley   +1 more source

Updates on Mediterranean diet and health status: active ingredients and pharmacological mechanisms

British Journal of Pharmacology, EarlyView.
The Mediterranean diet (MedDiet) is among the most extensively studied dietary patterns and has been consistently associated with reduced risk of all‐cause mortality, cardiovascular disease, metabolic disorders, cognitive decline and several types of cancers.
Lukas Schwingshackl, Jakub Morze, Sabina Wallerer, Georg Hoffmann   +3 more
wiley   +1 more source

Molecular Mechanisms of Palmitate Lipotoxicity and Unsaturated Fatty Acid Lipoprotection in Neuronal and Microglial Cells

, 2021
Nearly three-in-four Americans are overweight or obese. Obesity has long been recognized as a risk factor for several diseases. Obesogenic diseases often present comorbidly and include dyslipidemia, diabetes mellitus, cardiovascular disease, non ...
Urso, C.J.
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