Results 131 to 140 of about 28,679 (286)
Cancer Science, EarlyView.The lncRNA CROCCP2 upregulates HOXD11 by competitively adsorbing miR‐5584‐5p, thereby promoting glioma cell proliferation, migration, and invasion by inhibiting autophagy. It significantly enhances tumor growth in vivo, suggesting it may be a potential therapeutic target for gliomas.
Feng Wang +8 more
wiley +1 more source
Cell Proliferation, EarlyView.Hepatocyte TrkB is identified as a critical gatekeeper against MASH‐related fibrosis. Mechanistically, TrkB inhibits the TGFβ/SMAD3/FOS axis to suppress CCL2 secretion, thereby blocking pathogenic macrophage recruitment and ameliorating liver fibrosis.
Yueying Chen +11 more
wiley +1 more source
, 2015 Lipotoxicity could be defined as the deleterious effects exerted by lipids on plasma (normally as nonesterified molecules) on cell and tissues. Lipotoxicity is closely linked to obesity, although it can be observed in some lean individuals. Therefore, as overweight becomes more prevalent worldwide, the pathological effects mediated by lipotoxic ...
Martins,Ana Rita, Mas,Sebastian
openaire +1 more source
Lipotoxicity in smooth muscle [PDF]
, 2018 Thesis (Ph. D.) University of Missouri-Columbia 2006. ; The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. ; Vita.
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SCD2 Alleviates Diabetes‐Associated Cognitive Dysfunction by Improving Microglial Lipid Metabolism
Cell Proliferation, EarlyView.This study reveals a novel mechanism of microglial metabolic dysfunction in diabetic cognitive impairment. Defective SCD2 disrupts monounsaturated fatty acid (MUFA) metabolism, triggering mitochondrial oxidative phosphorylation dysfunction and leading to abnormal lipid droplet accumulation (marked by PLIN2).
Yang Yang +5 more
wiley +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims There is an unmet need for effective pharmacotherapy for obesity disease management in Japan. Survodutide is a novel glucagon receptor/glucagon‐like peptide‐1 receptor (GLP‐1R) dual agonist with the potential to induce greater weight reductions than GLP‐1R mono‐agonists. We report the design and baseline participant characteristics of the
Koutaro Yokote +10 more
wiley +1 more source
Acyl-CoA synthesis, lipid metabolism and lipotoxicity
, 2010 Although the underlying causes of insulin resistance have not been completely delineated, in most analyses, a recurring theme is dysfunctional metabolism of fatty acids.
Klett, Eric L. +2 more
core +1 more source
Enriched Metabolic Phenotyping Refines Phenotypic Resolution of Type 2 Diabetes
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims Data‐driven clustering studies of type 2 diabetes (T2D) based on limited routine clinical variables have reproducibly described major metabolic subgroups, including severe insulin‐deficient diabetes (SIDD), severe insulin‐resistant diabetes (SIRD), mild obesity‐related diabetes and mild age‐related diabetes.
Min Wang +6 more
wiley +1 more source
Is lipotoxicity an oxymoron? [PDF]
European Journal of Lipid Science and Technology, 2006 Friedrich Spener +2 more
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The FEBS Journal, EarlyView.Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump +10 more
wiley +1 more source