Results 141 to 150 of about 28,679 (286)

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

The emerging role of the Hippo signaling pathway in interorgan crosstalk

The FEBS Journal, EarlyView.
Hippo signaling functions as a central hub of interorgan communication. Systemic cues from the gut, adipose tissue, and skeletal muscle—including hormones, metabolites, and microbial signals—regulate YAP/TAZ activity in a tissue‐ and context‐dependent manner.
Gahyeon Song, Chaerin Lee, Eek‐hoon Jho   +2 more
wiley   +1 more source

Metabolic Determinants of Hepatic Lipotoxicity

, 2014
Lipotoxicity from free fatty acid overload has been implicated in a variety of diseases including type II diabetes and non-alcoholic fatty liver disease (NAFLD).
Egnatchik, Robert Anthony
core  

Enhanced oleate uptake and lipotoxicity associated with laurate

, 2015
Free fatty acids have been reported to induce cell death (lipotoxicity), but the effects depend on the carbon chain length and number of double bonds. Medium-chain saturated fatty acids (MC-SFAs), such as laurate, have less lipotoxicity than long-chain ...
Kana Inoue, Matsushita, Nahomi, Yoshiharu Shimomura, Shimomura, Yoshiharu, Naoki Kato, Kato, Naoki, Inoue, Kana, Kitaura, Yasuyuki, Yasuyuki Kitaura, Nahomi Matsushita   +9 more
core   +1 more source

Lipotoxicity in adrenoleukodystrophy

, 2018
X-linked adrenoleukodystrophy (ALD) is the most common leukodystrophy with a birth incidence of 1:14,700. ALD is characterized by impaired beta-oxidation and enhanced elongation of very long-chain fatty acids (VLCFA) due to a defect in the peroxisomal transmembrane protein ABCD1.
openaire   +2 more sources

Sirt5 improves cardiomyocytes fatty acid metabolism and ameliorates cardiac lipotoxicity in diabetic cardiomyopathy via CPT2 de-succinylation

Redox Biology
Rationale: The disruption of the balance between fatty acid (FA) uptake and oxidation (FAO) leads to cardiac lipotoxicity, serving as the driving force behind diabetic cardiomyopathy (DbCM).
Maoxiong Wu, Jing Tan, Zhengyu Cao, Yangwei Cai, Zhaoqi Huang, Zhiteng Chen, Wanbing He, Xiao Liu, Yuan Jiang, Qingyuan Gao, Bingqing Deng, Jingfeng Wang, Woliang Yuan, Haifeng Zhang, Yangxin Chen   +14 more
doaj   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Turnip mosaic virus utilizes the lipid droplet biogenesis machinery to facilitate its propagation in plants

New Phytologist, EarlyView.
Potyvirus turnip mosaic virus induces neutral lipid accumulation and lipid droplet biogenesis in infected leaves for its own benefit. Summary Lipid droplets (LDs), which are dedicated to storing neutral lipids (NLs), are dynamic organelles involved in numerous other functions, including membrane remodeling during abiotic stress.
Léna Jambou, Nathalie Arvy, Marguerite Batsale, Luc Sofer, Sara Shakir, Marielle Cochet, Vincent Simon, Charlotte Quinteau, Thomas Scotti, Nathan M. Doner, Satinder K. Gidda, Robert T. Mullen, Sabine D'Andréa, Jean‐Luc Gallois, Denis Coulon, Claire Bréhélin, Sylvie German‐Retana   +16 more
wiley   +1 more source

The downregulation of SCGN induced by lipotoxicity promotes NLRP3-mediated β-cell pyroptosis

Cell Death Discovery
Lipotoxicity is a well-established phenomenon that could exacerbate damage to islet β-cells and play a significant role in the development of type 2 diabetes, the underlying mechanisms of which, however, remain unclear.
Shuhui Ouyang, Sunmin Xiang, Xin Wang, Xin Yang, Xuan Liu, Meilin Zhang, Yiting Zhou, Yang Xiao, Lingzhi Zhou, Gang Fan, Jing Yang   +10 more
doaj   +1 more source

Mdivi-1 promotes lipid droplets-mitochondria contact and ameliorates cardiac lipotoxicity in high-fat diet-fed mice

Pharmacological Research
Myocardial lipid overload triggers excessive mitochondrial fission and impairs lipid droplets (LDs)-mitochondrial contact, thereby contributing to the development of lipotoxic cardiomyopathy.
Zujie Xu, Zheying Ma, Huiqian Ren, Yaming Yang, Xiaoqin Zhao, Bing Zhang   +5 more
doaj   +1 more source