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The Glomerular Physiology of Lipoxin-A
1988A number of renal diseases, such as acute and chronic glomerulonephritis, acute interstitial nephritis, allograft rejection, and others are characterized by the presence inflammatory cellular infiltrates consisting, at various stages, of neutrophils, macrophages, monocytes, eosinophils, and lymphocytes.
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1995
Lipoxins are a series of trihydroxylated derivatives of arachidonic acid formed by interaction of the 5- and 15-lipoxygenase pathways in human leukocytes. Lipoxin A4 is involved in the inflammatory process by inhibiting the cytotoxic activity of human natural killer cells and activating neutrophils.
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Lipoxins are a series of trihydroxylated derivatives of arachidonic acid formed by interaction of the 5- and 15-lipoxygenase pathways in human leukocytes. Lipoxin A4 is involved in the inflammatory process by inhibiting the cytotoxic activity of human natural killer cells and activating neutrophils.
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Lipoxin A₄ and benzo-lipoxin A₄ attenuate experimental renal fibrosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2011Unresolved inflammation underlies the development of fibrosis and organ failure. Here, we investigate the potential of the proresolving eicosanoid lipoxinA₄ (LXA₄) and its synthetic analog benzo-LXA₄ to prophylactically modulate fibrotic and inflammatory responses in a model of early renal fibrosis, unilateral ureteric obstruction (UUO).
Emma, Börgeson +9 more
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Lipoxin alleviates oxidative stress: a state-of-the-art review
Inflammation Research, 2022Chongge You, You Chong-Ge
exaly
Lipoxin biosynthesis and its impact in inflammatory and vascular events
Lipids and Lipid Metabolism, 1994Charles N Serhan
exaly