Results 71 to 80 of about 387 (131)

Resolution of Inflammation Through the Lipoxin and ALX/FPR2 Receptor Pathway Protects Against Abdominal Aortic Aneurysms

JACC: Basic to Translational Science, 2018
Summary: An abdominal aortic aneurysm (AAA) is a progressive aortic dilation that may lead to rupture, which is usually lethal. This study identifies the state of failure in the resolution of inflammation by means of decreased expression of the pro ...
Marcelo H. Petri, MD, PhD, Silke Thul, PhD, Teodora Andonova, MSc, Moritz Lindquist-Liljeqvist, MD, Hong Jin, MD, PhD, Nikolaos-Taxiarchis Skenteris, MSc, Hildur Arnardottir, PhD, Lars Maegdefessel, MD, PhD, Kenneth Caidahl, MD, PhD, Mauro Perretti, PhD, Joy Roy, MD, PhD, Magnus Bäck, MD, PhD   +11 more
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Intervertebral disc degeneration, inflammation, and bioactive lipids

Recent Trends in Pharmacology
Intervertebral disc degeneration, inflammation, and bioactive lipidsIntervertebral disc degenerationIntervertebral disc (IVD) degeneration is a common condition that is associated with significant morbidity.
Undurti Das, Ahmet Hacımüftüoğlu
doaj   +1 more source

Lipoxins A4 and B4 inhibit glial cell activation via CXCR3 signaling in acute retinal neuroinflammation

Journal of Neuroinflammation
Lipoxins are small lipids that are potent endogenous mediators of systemic inflammation resolution in a variety of diseases. We previously reported that Lipoxins A4 and B4 (LXA4 and LXB4) have protective activities against neurodegenerative injury.
Izhar Livne-Bar, Shubham Maurya, Karsten Gronert, Jeremy M. Sivak   +3 more
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Protective effect of soybean oil- or fish oil-rich diets on allergic airway inflammation

Journal of Inflammation Research, 2016
Roberta Araujo Navarro-Xavier,1 Karina Vieira de Barros,1 Iracema Senna de Andrade,1 Zaira Palomino,2 Dulce Elena Casarini,2 Vera Lucia Flor Silveira3 1Departamento de Fisiologia, 2Departamento de Medicina, 3Departamento de Ciências Bioló ...
Navarro-Xavier RA, Barros KV, Andrade IS, Palomino Z, Casarini DE, Flor Silveira VL   +5 more
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Conformational analysis of lipoxin A, lipoxin B and their trans-isomers

Lipids and Lipid Metabolism, 1988
Lipoxin A and lipoxin B (LXA and LXB) are formed from the oxygenation of arachidonic acid by interactions between the 5- and 15-lipoxygenases of human leukocytes. Each compound displays highly stereospecific biological actions. Here, we present a computational description of the following compounds: lipoxin A, (5S,6R,15S)-trihydroxy-7,9,13-trans-11-cis-
Charles N Serhan, Michel Deleers, Jean-Marie Ruysschaert   +2 more
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Lipoxins in inflammation

Clinical Hemorheology and Microcirculation, 2022
Lipoxins and ATL appear to be the first recognized members of a new class of endogenous mediator that are anti-inflammatory or serve for the “pro-resolution” of inflammation. PGE2 can and may display anti-inflammatory properties in certain settings, but in most cases, it enhances inflammation in vivo.
Shivani, Sachdeva, Harish, Saluja, Ameet, Mani, M B, Phadnaik, Shubhangi, Mani   +4 more
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Lipoxins and aspirin-triggered lipoxins in resolution of inflammation

European Journal of Pharmacology, 2015
The resolution of the inflammatory response is highly regulated by the timely biosynthesis of a number of endogenous lipid mediators. Among these, lipoxins (LX) and their 15-epimers, aspirin triggered lipoxins (ATL) derived by the lipoxygenase (LO) route of arachidonic acid metabolism. In particular, they are formed and released by cells expressing 5-,
ROMANO, Mario, CIANCI, ELEONORA, SIMIELE, FELICE, RECCHIUTI, ANTONIO   +3 more
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Lipoxins and lipoxin analogs in asthma

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2005
The pathobiology of asthma is characterized by production of eicosanoids, a diverse family of bioactive fatty acids that play important roles in regulating airway inflammation and reactivity. Lipoxins (LXs) are products of arachidonic acid metabolism that are distinct from leukotrienes (LTs) and prostaglandins (PGs) in structure and function.
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Lipoxin analogs and lipoxin formation in vivo

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2005
The definition of lipoxin bioactions in vivo and of lipoxin levels in humans, under physiological and pathological conditions, represents a main task toward the clinical use of lipoxins. The introduction of lipoxin stable analogs and of new methodology for immunological measurements of lipoxin A4 in human fluids is significantly contributing to fulfill
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Lipoxins and Aspirin-Triggered Lipoxins in Airway Responses

2003
Here, we have demonstrated potent inhibition of allergen-mediated pulmonary inflammation and airway hyper-responsiveness by a novel dual-pronged action of LX's. Moreover, these results indicate that LX's play pivotal and previously unappreciated roles in regulating allergy and pulmonary inflammation.
Bruce D, Levy, George T, De Sanctis, Pallavi R, Devchand, Eugene, Kim, Kate, Ackerman, Birgitta, Schmidt, Wojciech, Szczeklik, Jeffrey M, Drazen, Charles N, Serhan   +8 more
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