Results 11 to 20 of about 10,965 (171)
Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Virtual screening for NS5B inhibitors of Hepatitis C virus [PDF]
, 2012 Hepatitis C Virus (HCV) infection is a serious cause of chronic liver disease worldwide with more than 170 million infected individuals at a risk of developing significant morbidity and mortality.
Achuthsankar S. Nair +2 more
core +2 more sources
Targeting inflammation to reduce cardiovascular disease risk [PDF]
, 2017 This joint themed section of the British Journal of Pharmacology and the British Journal of Clinical Pharmacology stems from a joint British Pharmacological Society – Italian Society of Pharmacology symposium held at the 37th National Congress of the ...
Cirino, Guiseppe, Maffia, Pasquale
core +1 more source
Physiological levels of lipoxin A4 inhibit ENaC and restore airway surface liquid height in cystic fibrosis bronchial epithelium. [PDF]
, 2014 In cystic fibrosis (CF), the airway surface liquid (ASL) is depleted. We previously demonstrated that lipoxin A4 (LXA4) can modulate ASL height (ASLh) through actions on Cl(-) transport.
Al-Alawi, Mazen +8 more
core +5 more sources
The role of platelet microvesicles in intercellular communication. [PDF]
, 2016 In recent years, there has been exponential growth in the interest in microvesicles, which is reflected by the number of publications. Initially referred to as platelet dust by Peter Wolf in 1967, platelet microvesicles (PMV) are now recognized as ...
Edelstein, Leonard C.
core +2 more sources
Lipoxins and synthetic lipoxin mimetics: Therapeutic potential in renal diseases
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2021 Inflammation and its timely resolution are critical to ensuring effective host defence and appropriate tissue repair after injury. Unresolved inflammation typifies many renal pathologies. The key drivers of the inflammatory response are well defined and targeted by conventional anti-inflammatory therapeutics.
Darrell, Andrews, Catherine, Godson
openaire +2 more sources
Eicosanoid control over antigen presenting cells in asthma [PDF]
, 2018 Asthma is a common lung disease affecting 300 million people worldwide. Allergic asthma is recognized as a prototypical Th2 disorder, orchestrated by an aberrant adaptive CD4+ T helper (Th2/Th17) cell immune response against airborne allergens, that ...
Adelroth +180 more
core +2 more sources
Acetylsalicylic Acid Reduces the Severity of Dextran Sodium Sulfate-Induced Colitis and Increases the Formation of Anti-Inflammatory Lipid Mediators [PDF]
, 2013 The role of non-steroidal anti-inflammatory drugs in inflammatory bowel disease is controversial, as they have been implicated in disease aggravation. Different from other cyclooxygenase inhibitors, acetylsalicylic acid (ASA) enhances the formation of ...
Baumgart, Daniel C. +7 more
core +3 more sources
Type 2 Innate Lymphoid Cells in Allergic Disease. [PDF]
, 2013 Type II innate lymphoid cells (ILC2) are a novel population of lineage-negative cells that produce high levels of Th2 cytokines IL-5 and IL-13. ILC2 are found in human respiratory and gastrointestinal tissue as well as in skin.
Doherty, Taylor A +2 more
core +2 more sources