Results 31 to 40 of about 7,978 (212)
Molecules, 2021 Bacterial infection activates the innate immune system as part of the host’s defense against invading pathogens. Host response to bacterial pathogens includes leukocyte activation, inflammatory mediator release, phagocytosis, and killing of bacteria.
Julianne M. Thornton, Kingsley Yin
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Lipoxins: resolutionary road [PDF]
British Journal of Pharmacology, 2009 The resolution of inflammation is an active process controlled by endogenous mediators with selective actions on neutrophils and monocytes. The initial phase of the acute inflammatory response is characterized by the production of pro‐inflammatory mediators followed by a second phase in which lipid mediators with pro‐resolution activities may be ...
Paola, Maderna, Catherine, Godson
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Neural Regeneration Research, 2016 Lipoxin A4 can alleviate cerebral ischemia/reperfusion injury by reducing the inflammatory reaction, but it is currently unclear whether it has a protective effect on diabetes mellitus complicated by focal cerebral ischemia/reperfusion injury.
Jiang-quan Han +5 more
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Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing [PDF]
The Journal of Experimental Medicine, 2007 Inflammatory conditions can lead to debilitating and persistent pain. This hyperalgesia reflects sensitization of peripheral terminals and facilitation of pain signaling at the spinal level. Studies of peripheral systems show that tissue injury triggers not only inflammation but also a well-orchestrated series of events that leads to reversal of the ...
Svensson, Camilla +2 more
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Lipoxins and synthetic lipoxin mimetics: Therapeutic potential in renal diseases
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2021 Inflammation and its timely resolution are critical to ensuring effective host defence and appropriate tissue repair after injury. Unresolved inflammation typifies many renal pathologies. The key drivers of the inflammatory response are well defined and targeted by conventional anti-inflammatory therapeutics.
Darrell, Andrews, Catherine, Godson
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Formation of lipoxin A by granulocytes from eosinophilic donors [PDF]
, 1987 The formation of arachidonic acid-derived lipoxygenase products was examined with human granulocytes obtained from eosinophilic donors. These eosinophil-enriched leukocyte populations, challenged in vitro with the ionophore of divalent cations A23187 ...
Ulf Hirsch +7 more
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Novel biphasic role of lipoxinA4 on expression of cyclooxygenase-2 in lipopolysaccharide-stimulated lung fibroblasts [PDF]
, 2011 Fibroblasts are important to host defence and immunity, can also as initiators of inflammation as well. As the endogenous "braking signal", Lipoxins can regulate anti-inflammation and the resolution of inflammation.
Gao, F. +24 more
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The Role of Specialized Pro-Resolving Mediators in Cystic Fibrosis Airways Disease
Frontiers in Pharmacology, 2020 Cystic Fibrosis (CF) is a recessive genetic disease due to mutations of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene encoding the CFTR chloride channel. The ion transport abnormalities related to CFTR mutation generate a dehydrated
Maelle Briottet +2 more
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Lipoxins, Aspirin-Triggered Epi-Lipoxins, Lipoxin Stable Analogues, and the Resolution of Inflammation [PDF]
Journal of the American Society of Nephrology, 2002 Lipoxins (LX) are eicosanoids with antiinflammatory activity in glomerulonephritis (GN) and inflammatory diseases, hypersensitivity, and ischemia reperfusion injury. It has been demonstrated that LXA(4) stimulates non-phlogistic phagocytosis of apoptotic polymorphonuclear neutrophils (PMN) by monocyte-derived macrophages (Mphi) in vitro, suggesting a ...
Siobhan, Mitchell +11 more
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iScience, 2022 Summary: Adipose tissue inflammation drives obesity-related cardiometabolic diseases. Enhancing endogenous resolution mechanisms through administration of lipoxin A4, a specialized pro-resolving lipid mediator, was shown to reduce adipose inflammation ...
Matúš Soták +19 more
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