Results 11 to 20 of about 7,978 (212)
Lipoxin A4 promotes lung epithelial repair whilst inhibiting fibroblast proliferation [PDF]
ERJ Open Research, 2016 Therapy that promotes epithelial repair whilst protecting against fibroproliferation is critical for restoring lung function in acute and chronic respiratory diseases.
Shengxing Zheng +10 more
doaj +2 more sources
Mediators of Inflammation, 2013 The lipoxins are the first proresolution mediators to be recognized and described as the endogenous “braking signals” for inflammation. We evaluated the anti-inflammatory and proresolution bioactions of lipoxin A4 in our lipopolysaccharide (LPS-)induced ...
Yi Yang +10 more
doaj +2 more sources
Synthesis of aromatic lactone analogues of Lipoxin A4 [PDF]
BMC Research Notes, 2022 Objective Synthesis of novel aromatic Lipoxin A4 lactone analogues. Results Novel para-substituted aromatic lactone analogues of Lipoxin A4 have been synthesized in a convergent manner with six steps in the longest linear sequence in 12–13% yields ...
Aya Ismael +2 more
doaj +2 more sources
Lipoxin A4 Reduces Ventilator-Induced Lung Injury in Rats with Large-Volume Mechanical Ventilation
Mediators of Inflammation, 2020 Ventilator-induced lung injury (VILI) is a severe and inevitable complication in patients who require mechanical ventilation (MV) for respiratory support. Lipoxin A4 is an endogenous anti-inflammatory and antioxidant mediator.
Qi Wang +3 more
doaj +2 more sources
Dysregulation of neuroprotective lipoxin pathway in astrocytes in response to cytokines and ocular hypertension [PDF]
Acta Neuropathologica CommunicationsGlaucoma leads to vision loss due to retinal ganglion cell death. Astrocyte reactivity contributes to neurodegeneration. Our recent study found that lipoxin B4 (LXB4), produced by retinal astrocytes, has direct neuroprotective actions on retinal ganglion
Shruthi Karnam +6 more
doaj +2 more sources
Characterisation of the Fpr2 null mouse [PDF]
, 2010 PhDA novel Fpr2-/- mouse colony was used to explore the biology of Fpr2, a GPCR related to the human FPR2/ALX receptor that recognises lipoxin A4 (LXA4) annexin A1 (AnxA1) and serum amyloid A (SAA).
Dufton, Neil Peter
core +4 more sources
Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Resolution-Based Therapies: The Potential of Lipoxins to Treat Human Diseases
Frontiers in Immunology, 2021 Inflammation is an a physiological response instead an essential response of the organism to injury and its adequate resolution is essential to restore homeostasis.
Rafael I. Jaén +9 more
doaj +1 more source
Lipoxins: regulators of resolution [PDF]
Current Opinion in Pharmacology, 2010 Persistent inflammation underlies many prevalent diseases including atherosclerosis and diabetes. There is a growing appreciation that inflammation and its active resolution may be modulated by endogenously produced lipids. Pre-eminent amongst these mediators are lipoxin [LX]A4 and LXB4.
Ryan, Aidan, Godson, Catherine
openaire +4 more sources