Results 21 to 30 of about 6,087 (178)
Mediators of Inflammation, 2013 The lipoxins are the first proresolution mediators to be recognized and described as the endogenous “braking signals” for inflammation. We evaluated the anti-inflammatory and proresolution bioactions of lipoxin A4 in our lipopolysaccharide (LPS-)induced ...
Yi Yang +10 more
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Lipoxins: resolutionary road [PDF]
British Journal of Pharmacology, 2009 The resolution of inflammation is an active process controlled by endogenous mediators with selective actions on neutrophils and monocytes. The initial phase of the acute inflammatory response is characterized by the production of pro‐inflammatory mediators followed by a second phase in which lipid mediators with pro‐resolution activities may be ...
Paola, Maderna, Catherine, Godson
openaire +2 more sources
Lipoxins and synthetic lipoxin mimetics: Therapeutic potential in renal diseases
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2021 Inflammation and its timely resolution are critical to ensuring effective host defence and appropriate tissue repair after injury. Unresolved inflammation typifies many renal pathologies. The key drivers of the inflammatory response are well defined and targeted by conventional anti-inflammatory therapeutics.
Darrell, Andrews, Catherine, Godson
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Mediators of Inflammation, 2019 Our previous studies verified the potent anti-inflammatory effects against severe acute pancreatitis (SAP) of AT-Lipoxin A4 and their analogues. However, the anti-inflammatory effects of AT-Lipoxin A4 on SAP-associated lung injury are not thoroughly ...
Suhui Yu +7 more
doaj +1 more source
Biomolecules, 2022 A precision medicine approach is widely acknowledged to yield more effective therapeutic strategies in the treatment of patients with chronic inflammatory conditions than the prescriptive paradigm currently utilized in the management and treatment of ...
Jesmond Dalli +2 more
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Molecules, 2021 Bacterial infection activates the innate immune system as part of the host’s defense against invading pathogens. Host response to bacterial pathogens includes leukocyte activation, inflammatory mediator release, phagocytosis, and killing of bacteria.
Julianne M. Thornton, Kingsley Yin
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Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing [PDF]
The Journal of Experimental Medicine, 2007 Inflammatory conditions can lead to debilitating and persistent pain. This hyperalgesia reflects sensitization of peripheral terminals and facilitation of pain signaling at the spinal level. Studies of peripheral systems show that tissue injury triggers not only inflammation but also a well-orchestrated series of events that leads to reversal of the ...
Svensson, Camilla +2 more
openaire +4 more sources
Neural Regeneration Research, 2016 Lipoxin A4 can alleviate cerebral ischemia/reperfusion injury by reducing the inflammatory reaction, but it is currently unclear whether it has a protective effect on diabetes mellitus complicated by focal cerebral ischemia/reperfusion injury.
Jiang-quan Han +5 more
doaj +1 more source
The Lipoxin Receptor/FPR2 Agonist BML-111 Protects Mouse Skin Against Ultraviolet B Radiation
Molecules, 2020 Excessive exposure to UV, especially UVB, is the most important risk factor for skin cancer and premature skin aging. The identification of the specialized pro-resolving lipid mediators (SPMs) challenged the preexisting paradigm of how inflammation ends.
Renata M. Martinez +13 more
doaj +1 more source
Frontiers in Immunology, 2012 Unresolved inflammation is associated with several widely occurring diseases such as arthritis, periodontal diseases, cancer, and atherosclerosis.
Charles N Serhan, Antonio eRecchiuti
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