Results 21 to 30 of about 7,978 (212)

Granulation tissue enriched by aspirin and omega-3 fatty acids in healing experimental periodontal lesion

Biomedical Papers, 2021
Aims. Granulation tissue (GT) and specialized pro‑resolving mediators such as lipoxins and resolvins are key elements in the successful resolution of periodontitis.
Filip Hromcik, Jan Vokurka, Eduard Gopfert, Martin Faldyna, Marketa Hermanova, Michal Kyr, Monika Vicenova, Lydie Izakovicova Holla   +7 more
doaj   +1 more source

Influence of Lipoxin-A4 Treatment on Cytokine, Chemokine Genes Expression, and Phenotypic Distribution of Lymphocyte Subsets During Experimental Liver Fibrosis

, 2022
Objective: Lipoxins are anti-inflammatory, pro-resolving molecules that are secreted by immune cells such as neutrophils and macrophages. Lipoxins are a metabolite of the arachidonic acid pathway that resolve inflammation in fibrotic liver by producing ...
Elçin Latife Kurtoğlu, Zeynal Mete Karaca, Kayhan, Başak, Mehmet Gül, Mete Karaca, Zeynal, Latife Kurtoğlu, Elçin, Başak Kayhan, Gül, Mehmet   +7 more
core   +1 more source

Characteristic fragmentation of polyunsaturated fatty acids with allylic vicinal diols in positive-ion LC/ESI-MS/MS

Journal of Lipid Research, 2023
A characteristic fragmentation was observed for PUFAs that contain allylic vicinal diol groups (resolvin D1, D2, D4, E3, lipoxin A4, B4, and maresin 2), which were derivatized with N,N-dimethylethylenediamine (DMED), in positive-ion ESI-MS/MS.
Huibin Zhu, Mone Kurokawa, Mengyao Chen, Qiuyi Wang, Masayuki Inoue, Toshifumi Takao   +5 more
doaj   +1 more source

Up-Regulation of Annexin-A1 and Lipoxin A(4) in Individuals with Ulcerative Colitis May Promote Mucosal Homeostasis [PDF]

, 2012
PubMed ID: 22723974This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Jose G P Ferraz, Linda Vong, Panaccione, R, Panaccione Remo, Philip M. Sherman, Philip M Sherman, Perretti, M, Beck Paul L., Ferraz, JGP, Sherman Philip M., John L. Wallace, Vong Linda, Sherman, PM, Wallace John L., Mauro Perretti, Jose G. P. Ferraz, Paul L. Beck, Neil Dufton, Remo Panaccione, Dufton, N, Ferraz Jose G. P., Beck, PL, Dufton Neil, Wallace, JL, Vong, L, John L Wallace, Perretti Mauro, Paul L Beck   +27 more
core   +1 more source

Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators—What is the Evidence so far?

Frontiers in Pharmacology, 2022
Formation of specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of arachidonic acid 12- and 15-lipoxygenating paralogues (15-LO1, ALOX15; 15 ...
Nils Helge Schebb, Hartmut Kühn, Astrid S. Kahnt, Katharina M. Rund, Valerie B. O’Donnell, Nicolas Flamand, Marc Peters-Golden, Per-Johan Jakobsson, Karsten H. Weylandt, Nadine Rohwer, Nadine Rohwer, Robert C. Murphy, Gerd Geisslinger, Gerd Geisslinger, Garret A. FitzGerald, Julien Hanson, Julien Hanson, Claes Dahlgren, Mohamad Wessam Alnouri, Stefan Offermanns, Stefan Offermanns, Dieter Steinhilber, Dieter Steinhilber   +22 more
doaj   +1 more source

Role of the lipoxin A4 receptor in the development of neutrophil extracellular traps in Leishmania infantum infection

Parasites & Vectors, 2019
Background Neutrophils play an immunomodulatory role through the release of neutrophil extracellular traps (NETs). NETs are released in response to Leishmania infection, but the mechanism of NET extrusion has not been elucidated.
Furong Wei, Wenci Gong, Junyun Wang, Yuetao Yang, Jianxiu Liu, Yanjuan Wang, Jianping Cao   +6 more
doaj   +1 more source

Airway Lipoxin A4 Generation and Lipoxin A4 Receptor Expression Are Decreased in Severe Asthma

, 2022
Rationale: Airway inflammation is common in severe asthma despite antiinflammatory therapy with corticosteroids. Lipoxin A4 (LXA4) is an arachidonic acid–derived mediator that serves as an agonist for resolution of inflammation.
Gaston, Benjamin M., Wenzel, Sally E., Chung, Kian Fan, Planaguma, Anna, Castro, Mario, Haworth, Oliver, Israel, Elliot, Kazani, Shamsah, Levy, Bruce, Marigowda, Gautham, Busse, William W., Erzurum, Serpil C., Bleecker, Eugene R., Calhoun, William J., Jarjour, Nizar N., Mariani, Thomas J., Curran-Everett, Douglas   +16 more
core   +1 more source

Downregulation of TNF-α/TNF-R1 Signals by AT-Lipoxin A4 May Be a Significant Mechanism of Attenuation in SAP-Associated Lung Injury

Mediators of Inflammation, 2019
Our previous studies verified the potent anti-inflammatory effects against severe acute pancreatitis (SAP) of AT-Lipoxin A4 and their analogues. However, the anti-inflammatory effects of AT-Lipoxin A4 on SAP-associated lung injury are not thoroughly ...
Suhui Yu, Jianming Xie, Yukai Xiang, Shengjie Dai, Dinglai Yu, Hongwei Sun, Bicheng Chen, Mengtao Zhou   +7 more
doaj   +1 more source

The Lipoxin Receptor/FPR2 Agonist BML-111 Protects Mouse Skin Against Ultraviolet B Radiation

Molecules, 2020
Excessive exposure to UV, especially UVB, is the most important risk factor for skin cancer and premature skin aging. The identification of the specialized pro-resolving lipid mediators (SPMs) challenged the preexisting paradigm of how inflammation ends.
Renata M. Martinez, Victor Fattori, Priscila Saito, Ingrid C. Pinto, Camilla C. A. Rodrigues, Cristina P. B. Melo, Allan J. C. Bussmann, Larissa Staurengo-Ferrari, Julia Rojo Bezerra, Josiane A. Vignoli, Marcela M. Baracat, Sandra R. Georgetti, Waldiceu A Verri Jr., Rubia Casagrande   +13 more
doaj   +1 more source

Utility of the Specialized Pro-Resolving Mediators as Diagnostic and Prognostic Biomarkers in Disease

Biomolecules, 2022
A precision medicine approach is widely acknowledged to yield more effective therapeutic strategies in the treatment of patients with chronic inflammatory conditions than the prescriptive paradigm currently utilized in the management and treatment of ...
Jesmond Dalli, Esteban Alberto Gomez, Charlotte Camille Jouvene   +2 more
doaj   +1 more source