Results 101 to 110 of about 52,843 (179)

Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This review highlights protein lactylation as a metabolic‐epigenetic regulator linking lactate reprogramming to programmed cell death. By modulating histone and non‐histone targets, lactylation reshapes cell fate decisions and represents a promising biomarker and therapeutic target in human diseases.
Yue Chen, Xiwen Wang, Xiuping Wang, Na Lin, Wenjie Wang, Ruiqi Fu, Yutong Wu, Yi Liu, Hengwei Liu   +8 more
wiley   +1 more source

Post‐Tuberculosis Lung Disease: Clinicopathologic Insights, Diagnosis, Prevention, and Management

MedComm, Volume 7, Issue 10, October 2026.
A comprehensive review on post‐tuberculosis lung disease (PTLD) addresses the epidemiology, pathogenesis, clinical phenotypes and management, risk factors, prevention and systems approach, and future directions. This review provides standardized definitions, mechanistic insights and biomarkers of PTLD development, and clinical strategies for PTLD ...
Radha Gopalaswamy, Selvakumar Subbian
wiley   +1 more source

Inhibition of COX‐2‐Mediated Arachidonic Acid Metabolism by FGF21‐PPARα Axis Alleviates Liver Steatosis

MedComm, Volume 7, Issue 10, October 2026.
Under physiological conditions, the FGF21‐PPARα axis restrains COX‐2 and maintains arachidonic acid (AA) metabolic homeostasis. During steatotic liver disease, ERK1/2 phosphorylation increases alongside adaptive FGF21/PPARα activation, which is insufficient to suppress COX‐2, leading to COX‐driven AA remodeling, PGE2 accumulation, inflammation, and ...
Guangsen Xu, Tingting Pan, Guiyun Wang, Feng Qiu, Junlin Leng, Qiyang Feng, Yongguo Xue, Ye Wang, Junwei Zheng, Huiying Lu, Bingyan Han, Suntao Wang, Jie Du, Jiaojian Lv, Baile Wang, Xuebo Pan   +15 more
wiley   +1 more source

The 5-Lipoxygenase Pathway in Ovarian Cancer: Mechanisms of Metastasis, Chemoresistance, and Translational Targeting. [PDF]

Int J Womens Health
Li M, Zhu X, Gan L, Jiang H.
europepmc   +1 more source

Multifactorial Role of Phytogenic CeO2 NPs in Crop Improvement and Stress Alleviation: A Mechanistic Overview

Plant-Environment Interactions, Volume 7, Issue 5, October 2026.
The graphical abstract illustrates how CeO2 nanoparticles help plants withstand biotic and abiotic stresses. Their application reduces excessive ROS through enhanced antioxidant defenses, whereas modulating stress signaling, phytohormones, and gene expression.
Faiza Arooj, Khafsa Malik, Tahira Sultana, Abeer Kazmi, Md. Fakhrul Islam, Rafia Azam, Munaza Iram   +6 more
wiley   +1 more source

Soybean induced resistance to Spodoptera eridania herbivory

Pest Management Science, Volume 82, Issue 10, Page 9931-9943, October 2026.
SOD, CAT, APX, PPO, KTI, and MDA levels were higher in the resistant soybean. S. eridania herbivory increased H2O2 and MDA, but decreased SOD and PPO levels. S. eridania herbivory increased KTI activity only in the resistant variety. Isoquercitrin and daidzin were exclusive to resistant and susceptible soybeans.
Bruno Henrique Sardinha de Souza, Arlindo Leal Boiça Júnior, Durvalina Maria Mathias dos Santos, Moacir Rossi Forim, Antonio Pizolato Neto, Andreísa Fabri Lima, Michael Joseph Stout   +6 more
wiley   +1 more source

8-Iso-Prostaglandin F2α and Lipoxygenase Gene Expression as Candidate Molecular Markers of Training Adaptation in Professional Volleyball Players: A Pilot Study. [PDF]

Int J Mol Sci
Baran K, Podgórski R, Grzesik-Pietrasiewicz M, Czarny W, Król P, Połeć J, Gouveia ÉR, Cieśla M.   +7 more
europepmc   +1 more source

Epicardial adipose tissue‐linked leukotriene and cytokine signalling pathways – novel targets for prevention of obesity‐ and diabetes‐linked ventricular arrhythmia

The Journal of Physiology, EarlyView.
Kelly A. Aromolaran, Ademuyiwa S. Aromolaran   +1 more
wiley   +1 more source

Ya‐Jie‐Sha‐Ba Decoction Regulates Arachidonic Acid Metabolism to Treat Alcohol‐Associated Liver Disease by Activating PPARα–CYP4A14 Axis: Insights From Multi‐Omics Analysis and Experimental Validations

Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT Ya‐Jie‐Sha‐Ba decoction (YJSB), a traditional Dai medicinal formulation, has been widely used by the Dai ethnic group and has shown efficacy in alleviating alcohol‐associated liver disease (ALD). However, the molecular mechanism of YJSB in the management of ALD remains unclear.
Dehong Ma, Xia Chen, Huixian Dao, Hongyu Deng, Yingcheng Guo, Hui Yang, Yuanyuan Chen, Congmei Zhang, Yuan Long, Weibo Wen, Yinghong Zhao, Huantian Cui   +11 more
wiley   +1 more source

ALOX5-Mediated LTA4 Production Enhances PLCG2/IP3 Signaling and Exacerbates Calcification in Human Aortic Valve Interstitial Cells. [PDF]

Acta Cardiol Sin
Liu S, Chen K, Jia G, Hou W, Liu J, Zhang F.   +5 more
europepmc   +1 more source