Thiocarbohydrazone and Chalcone-Derived 3,4-Dihydropyrimidinethione as Lipid Peroxidation and Soybean Lipoxygenase Inhibitors. [PDF]
ACS Omega, 2023 Georgiou N +11 more
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Isothiocyanates as Ferroptosis Inducers to Promote Cancer Cell Death
Phytotherapy Research, EarlyView.ABSTRACT Cancer remains a leading cause of global mortality, with the therapeutic efficacy of anticancer drugs often hampered by late diagnosis and the development of chemotherapy resistance. Ferroptosis is an iron‐dependent form of regulated non‐apoptotic cell death driven by lipid peroxidation.
Valentina Citi +6 more
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Synthesis, Biological Evaluation, and Molecular Dynamics of Carbothioamides Derivatives as Carbonic Anhydrase II and 15-Lipoxygenase Inhibitors. [PDF]
Molecules, 2022 Channar PA +4 more
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Lipoxygenase-derived eicosanoids in myocardial ischaemia-reperfusion injury: the role of sensory C-fibres and TRPV1 [PDF]
, 2010 PhDIt is well established that the 12-lipoxygenase (12-LOX) pathway of arachidonic acid (AA) metabolism is stimulated within the myocardium by episodes of ischaemia, and there is considerable evidence showing that eicosanoids derived via this pathway ...
Goddard, Alison
core
Effect of catechol derivatives on cell growth and lipoxygenase activity [PDF]
, 2003 Derivatives of salicylic acid have been synthesized as potential lipoxygenase inhibitors. Agents containing a phenolic dihydroxy moiety showed potent (IC(50)10(-6)-10(-7) M) inhibition of the growth of murine colonic tumour cells in vitro, and were ...
Rathbone, DL +4 more
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Smart Molecules, EarlyView.A green and simple photo‐oxygenation of benzylic C‐H bond with molecular oxygen was developed for the preparation of a series of carbonyl compounds. The straightforward C‐H carbonylation strategy features catalyst‐ and additive‐free reaction conditions, only oxygen as a green oxidant, broad scope and scalable, and the simple‐operation nature.
Jianing Li +6 more
wiley +1 more source
2-Arylalkyl-substituted anthracenones as inhibitors of 12-lipoxygenase enzymes. 1. Structure–activity relationships of the terminal aryl ring [PDF]
, 2001 A series of 2-arylmethyl-substituted anthracenones were synthesized and tested as inhibitors of three types of 12-lipoxygenase isoforms in epidermal homogenate of mice, bovine platelets and porcine leucocytes.
Müller, K
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Unraveling the Physicochemical Landscape of Organoselenium Compounds in Nanocarrier Systems
The Chemical Record, EarlyView.Main nanocarriers employed to enhance the bioavailability and transport of organoselenium compounds. The image illustrates the key interaction forces that stabilize these organoselenium species in solution, enabling their application in drug delivery systems, catalysis, photoelectronic devices, and sensing technologies. In recent years, publications on
Romelly Eugenia Rojas Ramírez +3 more
wiley +1 more source
Identification of Novel Arachidonic Acid 15-Lipoxygenase Inhibitors Based on the Bayesian Classifier Model and Computer-Aided High-Throughput Virtual Screening. [PDF]
Pharmaceuticals (Basel), 2022 Liao Y, Cao P, Luo L.
europepmc +1 more source