Myrtucommulone from Myrtus communis exhibits potent anti-inflammatory effectiveness in vivo. [PDF]
, 2009 Myrtucommulone a nonprenylated acylphloroglucinol contained in the leaves of myrtle (Myrtus communis), has been reported to suppress the biosynthesis of eicosanoids by inhibition of 5-lipoxygenase and cyclooxygenase-1 in vitro and to inhibit the release ...
BRAMANTI P. +10 more
core +1 more source
Inflammation, Immunity, and Cardiovascular Diseases
Med Research, EarlyView.Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo +8 more
wiley +1 more source
Selective COX-2 inhibitors and risk of myocardial infarction [PDF]
, 2005 Selective inhibitors of cyclooxygenase- 2 ( COX- 2, ` coxibs') are highly effective anti-inflammatory and analgesic drugs that exert their action by preventing the formation of prostanoids.
Klauss, V. +3 more
core +1 more source
Thiocarbohydrazone and Chalcone-Derived 3,4-Dihydropyrimidinethione as Lipid Peroxidation and Soybean Lipoxygenase Inhibitors. [PDF]
ACS Omega, 2023 Georgiou N +11 more
europepmc +1 more source
Ferroptosis and Its Emerging Role in Gestational Diabetes Mellitus
Medicine Advances, EarlyView.Ferroptosis contributes to the development of gestational diabetes mellitus (GDM) through iron overload, lipid peroxidation, and antioxidant system disruption. These changes impair adipocyte and β‐cell function, promoting insulin resistance and hyperglycemia.
Jinfeng Xu +4 more
wiley +1 more source
Synthesis, Biological Evaluation, and Molecular Dynamics of Carbothioamides Derivatives as Carbonic Anhydrase II and 15-Lipoxygenase Inhibitors. [PDF]
Molecules, 2022 Channar PA +4 more
europepmc +1 more source
A new perspective on radiotherapy in the comprehensive treatment of cancer
Precision Radiation Oncology, EarlyView.Radiotherapy remains a key component in the comprehensive management of cancer. Its effectiveness is significantly improved through strategic combinations with chemotherapy, targeted therapy, and immunotherapy, providing a range of therapeutic outcomes from cure to palliative care.
Yingze Ma +4 more
wiley +1 more source
The aflatoxin B1-fumonisin B1 toxicity in BRL-3A hepatocytes is associated to induction of cytochrome P450 activity and arachidonic acid metabolism [PDF]
, 2017 Human oral exposure to aflatoxin B1 (AFB1) and fumonisin B1 (FB1) is associated with increased hepatocellular carcinoma. Although evidence suggested interactive AFB1–FB1 hepatotoxicity, the underlying mechanisms remain mostly unidentified.
Arias, Silvina Lorena +5 more
core +1 more source
Drought stress modulates indirect defense via bottom‐up effects in tomato and wheat
Pest Management Science, EarlyView.Different water regimes can have a significant impact on plant morphology and defense pathways in tomato and wheat, triggering multiple olfactory choices in biocontrol agents of key insect pests. These findings could be used to implement biocontrol strategies within the IPM context under a changing climate scenario.
Mariangela Milordo +8 more
wiley +1 more source