Avenanthramides as lipoxygenase inhibitors [PDF]
Heliyon, 2020 Avenanthramides (AVAs) present in oats are amides of anthranilic and cinnamic acids. AVAs are potent antioxidants and have anti-inflammatory properties.
Rikard Landberg +2 more
doaj +7 more sources
Bioactive Peptides and Protein Hydrolysates as Lipoxygenase Inhibitors [PDF]
Biology, 2023 Lipoxygenases are non-heme iron-containing enzymes that catalyze the oxidation of polyunsaturated fatty acids, resulting in the production of lipid hydroperoxides, which are precursors of inflammatory lipid mediators. These enzymes are widely distributed
Fai-Chu Wong, Tsun-Thai Chai
doaj +2 more sources
Design and synthesis of new esters of terpenoid alcohols as 15-lipoxygenase inhibitors [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): 15-Lipoxygenases are one of the iron-containing proteins capable of performing peroxidation of unsaturated fatty acids in animals and plants. The critical role of enzymes in the formation of inflammations, sensitivities, and some cancers has
Hamid Sadeghian +2 more
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5-Lipoxygenase inhibitors attenuate TNF-α-induced inflammation in human synovial fibroblasts. [PDF]
PLoS ONE, 2014 The lipoxygenase isoform of 5-lipoxygenase (5-LOX) is reported to be overexpressed in human rheumatoid arthritis synovial tissue and involved in the progress of inflammatory arthritis.
Han-Ching Lin +9 more
doaj +2 more sources
A high-throughput mass spectrometric assay for discovery of human lipoxygenase inhibitors and allosteric effectors. [PDF]
Anal Biochem, 2015 Lipoxygenases (LOXs) regulate inflammation through the production of a variety of molecules whose specific downstream effects are not entirely understood due to the complexity of the inflammation pathway.
Jameson JB, Kenyon V, Holman TR.
europepmc +3 more sources
CD69 is a TGF-β/1α,25-dihydroxyvitamin D3 target gene in monocytes. [PDF]
PLoS ONE, 2013 CD69 is a transmembrane lectin that can be expressed on most hematopoietic cells. In monocytes, it has been functionally linked to the 5-lipoxygenase pathway in which the leukotrienes, a class of highly potent inflammatory mediators, are produced ...
Thea K Wöbke +3 more
doaj +5 more sources
α-Conotoxins Enhance both the In Vivo Suppression of Ehrlich carcinoma Growth and In Vitro Reduction in Cell Viability Elicited by Cyclooxygenase and Lipoxygenase Inhibitors [PDF]
Marine Drugs, 2020 Several biochemical mechanisms, including the arachidonic acid cascade and activation of nicotinic acetylcholine receptors (nAChRs), are involved in increased tumor survival. Combined application of inhibitors acting on these two pathways may result in a
Alexey V. Osipov +6 more
doaj +2 more sources
Microwave Assisted Synthesis of Antioxidant Dihydro-Pyrazole Hybrids as Possible Lipoxygenase Inhibitors [PDF]
MoleculesFree radicals and inflammation have pivotal role in various degenerative diseases like cancer, rheumatoid arthritis, diabetes, cardiovascular and neurodegenerative disorders.
Stergiani-Chrysovalanti Peitzika +2 more
doaj +2 more sources
A fluorescence-based assay for measuring the redox potential of 5-lipoxygenase inhibitors. [PDF]
PLoS ONE, 2014 The activities and side effects of 5-lipoxygenase (5-LO) inhibitors can be predicted by identifying their redox mechanisms. In this study, we developed a fluorescence-based method to measure the redox potential of 5-LO inhibitors and compared it to the ...
Sangchul Lee +3 more
doaj +2 more sources
Design, synthesis, and computational studies on dihydropyrimidine scaffolds as potential lipoxygenase inhibitors and cancer chemopreventive agents [PDF]
Drug Design, Development and Therapy, 2015 Katharigatta N Venugopala,1,2 Reshme Govender,2 Mohammed A Khedr,1,3 Rashmi Venugopala,4 Bandar E Aldhubiab,1 Sree Harsha,1 Bharti Odhav2 1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Kingdom of ...
Venugopala KN +6 more
doaj +2 more sources