Results 11 to 20 of about 46,425 (297)

A fluorescence-based assay for measuring the redox potential of 5-lipoxygenase inhibitors. [PDF]

PLoS ONE, 2014
The activities and side effects of 5-lipoxygenase (5-LO) inhibitors can be predicted by identifying their redox mechanisms. In this study, we developed a fluorescence-based method to measure the redox potential of 5-LO inhibitors and compared it to the ...
Sangchul Lee, Youngsam Park, Junghwan Kim, Sung-Jun Han   +3 more
doaj   +2 more sources

Synthesis and structure-activity relationships of novel 5-(hydroxamic acid)methyl oxazolidinone derivatives as 5-lipoxygenase inhibitors. [PDF]

J Enzyme Inhib Med Chem, 2020
Phillips OA, Bosso MA, Ezeamuzie CI.
europepmc   +3 more sources

Synthesis and Molecular Modeling of Antioxidant and Anti-Inflammatory Five-Membered Heterocycle–Cinnamic Acid Hybrids [PDF]

Molecules
In this study, the design and synthesis of a novel series of cinnamic acid and 1,2,4-triazole hybrids were reported, aiming to enhance antioxidant and lipoxygenase inhibitory activities through pharmacophore combination. Cinnamic acid derivatives and 1,2,
Konstantinos Theodoridis, Eleftherios Charissopoulos, Dimitra Tsioumela, Eleni Pontiki   +3 more
doaj   +2 more sources

Design, synthesis, and computational studies on dihydropyrimidine scaffolds as potential lipoxygenase inhibitors and cancer chemopreventive agents [PDF]

Drug Design, Development and Therapy, 2015
Katharigatta N Venugopala,1,2 Reshme Govender,2 Mohammed A Khedr,1,3 Rashmi Venugopala,4 Bandar E Aldhubiab,1 Sree Harsha,1 Bharti Odhav2 1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Kingdom of ...
Venugopala KN, Govender R, Khedr MA, Venugopala R, Aldhubiab BE, Harsha S, Odhav B   +6 more
doaj   +2 more sources

The Inhibition of 15-Lipoxygenase by Blechnum orientale Leaves and its Glycoside-flavonoid Isolates: In Vitro and In Silico Studies

Hayati Journal of Biosciences, 2022
Fern is one of the groups of primitive plants rich in secondary metabolites that are commonly used to treat various diseases, including antioxidant, anti-hyaluronidase, anti-inflammation, and respiratory disease but less investigated.
Rissyelly Rissyelly, Syaikhul Aziz, Frangky Sangande, Agung Wibawa Mahatva Yodha, Krisyanti Budipramana, Elfahmi Elfahmi, Sukrasno Sukrasno   +6 more
doaj   +1 more source

Different Structures—Similar Effect: Do Substituted 5-(4-Methoxyphenyl)-1H-indoles and 5-(4-Methoxyphenyl)-1H-imidazoles Represent a Common Pharmacophore for Substrate Selective Inhibition of Linoleate Oxygenase Activity of ALOX15?

Molecules, 2023
Mammalian 15-lipoxygenases (ALOX15) are lipid peroxidizing enzymes that exhibit variable functionality in different cancer and inflammation models. The pathophysiological role of linoleic acid- and arachidonic acid-derived ALOX15 metabolites rendered ...
Alexander Zhuravlev, Alejandro Cruz, Vladislav Aksenov, Alexey Golovanov, José M. Lluch, Hartmut Kuhn, Àngels González-Lafont, Igor Ivanov   +7 more
doaj   +1 more source

A review on the relationship between Arachidonic acid 15-Lipoxygenase (ALOX15) and diabetes mellitus [PDF]

PeerJ, 2023
Arachidonic acid 15-lipoxygenase (ALOX15), as one of the lipoxygenase family, is mainly responsible for catalyzing the oxidation of various fatty acids to produce a variety of lipid components, contributing to the pathophysiological processes of various ...
Kaiying He, Xiaochun Zhou, Hongxuan Du, Jing Zhao, Rongrong Deng, Jianqin Wang   +5 more
doaj   +2 more sources

Biosynthesis of the Novel Endogenous 15-Lipoxygenase Metabolites N-13-Hydroxy-octodecadienoyl-ethanolamine and 13-Hydroxy-octodecadienoyl-glycerol by Human Neutrophils and Eosinophils

Cells, 2021
The endocannabinoids 2-arachidonoyl-glycerol and N-arachidonoyl-ethanolamine are lipids regulating many physiological processes, notably inflammation. Endocannabinoid hydrolysis inhibitors are now being investigated as potential anti-inflammatory agents.
Anne-Sophie Archambault, Francesco Tinto, Élizabeth Dumais, Volatiana Rakotoarivelo, Magdalena Kostrzewa, Pier-Luc Plante, Cyril Martin, Mélissa Simard, Cristoforo Silvestri, Roxane Pouliot, Michel Laviolette, Louis-Philippe Boulet, Rosa Maria Vitale, Alessia Ligresti, Vincenzo Di Marzo, Nicolas Flamand   +15 more
doaj   +1 more source

Novel lipoxygenase inhibitors as neuroprotective reagents [PDF]

Journal of Neuroscience Research, 2007
AbstractThe lipid‐metabolizing enzyme 12/15‐lipoxygenase (12/15‐LOX) mediates cell death resulting from oxidative stress in both neurons and oligodendrocytes. Specifically, it may contribute to the pathophysiology of stroke and Alzheimer's and Parkinson's diseases.
van Leyen, Klaus, Arai, Ken, Jin, Guang, Kenyon, Victor, Gerstner, Bettina, Rosenberg, Paul A, Holman, Theodore R, Lo, Eng H   +7 more
openaire   +4 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source