Results 1 to 10 of about 4,204 (130)

Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium. [PDF]

PLoS ONE, 2012
A mouse model with compromised mitochondrial fatty acid synthesis has been engineered in order to assess the role of this pathway in mitochondrial function and overall health.
Stuart Smith, Andrzej Witkowski, Ayesha Moghul, Yuko Yoshinaga, Michael Nefedov, Pieter de Jong, Dejiang Feng, Loren Fong, Yiping Tu, Yan Hu, Stephen G Young, Thomas Pham, Carling Cheung, Shana M Katzman, Martin D Brand, Casey L Quinlan, Marcel Fens, Frans Kuypers, Stephanie Misquitta, Stephen M Griffey, Son Tran, Afshin Gharib, Jens Knudsen, Hans Kristian Hannibal-Bach, Grace Wang, Sandra Larkin, Jennifer Thweatt, Saloni Pasta   +27 more
doaj   +15 more sources

Protein lipoylation in cancer: metabolic reprogramming and therapeutic potential [PDF]

Cell Death Discovery
Protein lipoylation, a mitochondria-specific post-translational modification (PTM) evolutionarily conserved from bacteria to mammals, plays critical role in metabolic processes. In humans, four identified lipoylated proteins serve as essential components
Sainan Li, Yingchao Liu, Wanye Hu, Aoli Deng, Xueying Ren, Lulu Chen, Yajuan Lu, Yunyi Wu, Hangqi Huang, Jinghao Cao, Jing Du, Jun Xia, Yanchun Li   +12 more
doaj   +2 more sources

Deep Mutational Scanning of FDX1 Identifies Key Structural Determinants of Lipoylation and Cuproptosis [PDF]

Nature Communications
Cuproptosis is a recently described form of regulated cell death triggered by ionophore-induced copper (Cu) overload in mitochondria. It is critically dependent on ferredoxin 1 (FDX1), a mitochondrial iron-sulfur cluster containing protein that acts as ...
Jeffrey C. Hsiao, Douglas M. Warui, Jason J. Kwon, Margaret B. Dreishpoon, Nolan R. Bick, Tamra Blue-Lahom, David E. Root, Squire J. Booker, Peter Tsvetkov   +8 more
doaj   +2 more sources

Lipoic Acid Metabolism as a Potential Chemotherapeutic Target Against Plasmodium falciparum and Staphylococcus aureus [PDF]

Frontiers in Chemistry, 2021
Lipoic acid (LA) is an organic compound that plays a key role in cellular metabolism. It participates in a posttranslational modification (PTM) named lipoylation, an event that is highly conserved and that occurs in multimeric metabolic enzymes of very ...
Sun Liu Rei Yan, Felipe Wakasuqui, Xiaochen Du, Matthew R. Groves, Carsten Wrenger   +4 more
doaj   +3 more sources

Boosting energy metabolism and biosynthesis in diverse organisms by a common bacterial salvage lipoylation protein [PDF]

Nature Communications
Lipoylation is a highly conserved post-translational modification (PTM) crucial for energy metabolism enzymes, with distinct pathways across organisms. Whereas bacteria like Escherichia coli inherit both salvage and de novo pathways, only the latter is ...
Runqing Yang, Yingying Wang, Minghua Kong, Zhijuan Hu, Zhe Zhang, Kun Shen, Jiali Meng, An-Ping Zeng   +7 more
doaj   +2 more sources

A response to iron involving carbon metabolism in the opportunistic fungal pathogen Candida albicans [PDF]

mSphere
Iron (Fe) is an essential micronutrient, and during infection, the host attempts to starve pathogens of this vital element through a process known as nutritional immunity.
Ritu Garg, Zhengkai Zhu, Francisco G. Hernandez, Yiran Wang, Marika S. David, Vincent M. Bruno, Valeria C. Culotta   +6 more
doaj   +2 more sources

CoA‐dependent activation of mitochondrial acyl carrier protein links four neurodegenerative diseases [PDF]

EMBO Molecular Medicine, 2019
PKAN, CoPAN, MePAN, and PDH‐E2 deficiency share key phenotypic features but harbor defects in distinct metabolic processes. Selective damage to the globus pallidus occurs in these genetic neurodegenerative diseases, which arise from defects in CoA ...
Roald A Lambrechts, Hein Schepers, Yi Yu, Marianne van der Zwaag, Kaija J Autio, Marcel A Vieira‐Lara, Barbara M Bakker, Marina A Tijssen, Susan J Hayflick, Nicola A Grzeschik, Ody CM Sibon   +10 more
doaj   +3 more sources

Staphylococcus aureus exploits lipoic acid salvage to combat host oxidative stress [PDF]

Cell Reports
Summary: Phagocytic leukocytes employ reactive oxygen species to defend against pathogenic microorganisms. The bacterial pathogen Staphylococcus aureus adapts to oxidative stress by producing antioxidant enzymes and small molecules to protect proteins ...
Iván C. Acosta, Andrew Albers, Liwei Fang, Gustavo Serrato, Wei Ping Teoh, David G. Glanville, Francis Alonzo, III   +6 more
doaj   +2 more sources

FDX1-mediated cuproptosis promotes cholestatic liver injury exacerbated by taurocholic acid-enhanced copper accumulation [PDF]

Cell Death Discovery
Cholestatic liver injury, characterized by direct exposure of hepatocytes to retained bile components with elevated concentrations, represents a common manifestation of various hepatobiliary disorders with persistent threats to long-term patient survival
Yujun Guo, Min Yang, Shengbo Sun, Zhaohua Zhong, Wenjun Lu, Ze’nan Zhang, Meili Fan, Aodan Zhang, Tingting Zhang, Yang Wu, Zhou Li, Zuwei Liu, Qijun Sun, Zhaozhu Li, Qingbo Cui   +14 more
doaj   +2 more sources

Fruit-specific overexpression of lipoyl synthase increases both bound and unbound lipoic acid and alters the metabolome of tomato fruits [PDF]

Frontiers in Plant Science
IntroductionLipoic acid (LA) is a key, yet overlooked player in primary metabolism, due to its role as a cofactor for various multi enzymatic complexes such as the E2 subunits of pyruvate dehydrogenase (PDH) and alpha-ketoglutarate dehydrogenase (kGDH ...
María Paz Covarrubias, Felipe Uribe, Daniela Arias-G, Pamela Cabedo, Michael Handford   +4 more
doaj   +2 more sources