Results 1 to 10 of about 3,490 (194)

Engineered bacterial lipoate protein ligase A (lplA) restores lipoylation in cell models of lipoylation deficiency. [PDF]

J Biol Chem
Protein lipoylation, a vital lysine post-translational modification, plays a crucial role in the function of key mitochondrial tricarboxylic acid cycle enzymatic complexes. In eukaryotes, lipoyl post-translational modification synthesis occurs exclusively through de novo pathways, relying on lipoyl synthesis/transfer enzymes, dependent upon ...
Bick NR, Dreishpoon MB, Perry A, Rogachevskaya A, Bottomley SS, Fleming MD, Ducamp S, Tsvetkov P.   +7 more
europepmc   +5 more sources

Protein lipoylation in cancer: metabolic reprogramming and therapeutic potential [PDF]

Cell Death Discovery
Protein lipoylation, a mitochondria-specific post-translational modification (PTM) evolutionarily conserved from bacteria to mammals, plays critical role in metabolic processes. In humans, four identified lipoylated proteins serve as essential components
Sainan Li, Yingchao Liu, Wanye Hu, Aoli Deng, Xueying Ren, Lulu Chen, Yajuan Lu, Yunyi Wu, Hangqi Huang, Jinghao Cao, Jing Du, Jun Xia, Yanchun Li   +12 more
doaj   +2 more sources

A unique lipoylation system in the Archaea [PDF]

The FEBS Journal, 2009
Members of the 2-oxoacid dehydrogenase multienzyme complex family play a key role in the pathways of central metabolism. Post-translational lipoylation of the dihydrolipoyl acyltransferase component of these complexes is essential for their activity, the lipoyllysine moiety performing the transfer of substrates and intermediates between the different ...
Mareike G. Posner, Abhishek Upadhyay, Stefan Bagby, David W. Hough, Michael J. Danson   +4 more
openalex   +4 more sources

A response to iron involving carbon metabolism in the opportunistic fungal pathogen Candida albicans [PDF]

mSphere
Iron (Fe) is an essential micronutrient, and during infection, the host attempts to starve pathogens of this vital element through a process known as nutritional immunity.
Ritu Garg, Zhengkai Zhu, Francisco G. Hernandez, Yiran Wang, Marika S. David, Vincent M. Bruno, Valeria C. Culotta   +6 more
doaj   +2 more sources

Staphylococcus aureus exploits lipoic acid salvage to combat host oxidative stress [PDF]

Cell Reports
Summary: Phagocytic leukocytes employ reactive oxygen species to defend against pathogenic microorganisms. The bacterial pathogen Staphylococcus aureus adapts to oxidative stress by producing antioxidant enzymes and small molecules to protect proteins ...
Iván C. Acosta, Andrew Albers, Liwei Fang, Gustavo Serrato, Wei Ping Teoh, David G. Glanville, Francis Alonzo, III   +6 more
doaj   +2 more sources

FDX1-mediated cuproptosis promotes cholestatic liver injury exacerbated by taurocholic acid-enhanced copper accumulation [PDF]

Cell Death Discovery
Cholestatic liver injury, characterized by direct exposure of hepatocytes to retained bile components with elevated concentrations, represents a common manifestation of various hepatobiliary disorders with persistent threats to long-term patient survival
Yujun Guo, Min Yang, Shengbo Sun, Zhaohua Zhong, Wenjun Lu, Ze’nan Zhang, Meili Fan, Aodan Zhang, Tingting Zhang, Yang Wu, Zhou Li, Zuwei Liu, Qijun Sun, Zhaozhu Li, Qingbo Cui   +14 more
doaj   +2 more sources

ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex [PDF]

Nature Communications, 2020
2-oxoglutarate links mitochondrial metabolism to oxygen sensing, gene transcription and epigenetic modifications. Here, the authors describe a mutagenesis screen to find genes that control 2-oxoglutarate levels, and identify ABHD11 as a mitochondrial ...
Peter S. J. Bailey, Brian M. Ortmann, Anthony W. Martinelli, Jack W. Houghton, Ana S. H. Costa, Stephen P. Burr, Robin Antrobus, Christian Frezza, James A. Nathan   +8 more
doaj   +2 more sources

Lipoylation of Acyltransferase Components of α-Ketoacid Dehydrogenase Complexes [PDF]

Journal of Biological Chemistry, 1996
Lipoic acid is a prosthetic group of the acyltransferase components of the pyruvate, alpha-ketoglutarate, and branched chain alpha-ketoacid dehydrogenase complexes, protein X of the eukaryotic pyruvate dehydrogenase complex, and H-protein of the glycine cleavage system.
Kazuko Fujiwara, Kazuko Okamura‐Ikeda, Yutaro Motokawa   +2 more
openalex   +4 more sources

A Multi-Target Pharmacological Correction of a Lipoyltransferase LIPT1 Gene Mutation in Patient-Derived Cellular Models [PDF]

Antioxidants
Mutations in the lipoyltransferase 1 (LIPT1) gene are rare inborn errors of metabolism leading to a fatal condition characterized by lipoylation defects of the 2-ketoacid dehydrogenase complexes causing early-onset seizures, psychomotor retardation ...
David Gómez-Fernández, Ana Romero-González, Juan M. Suárez-Rivero, Paula Cilleros-Holgado, Mónica Álvarez-Córdoba, Rocío Piñero-Pérez, José Manuel Romero-Domínguez, Diana Reche-López, Alejandra López-Cabrera, Salvador Ibáñez-Mico, Marta Castro de Oliveira, Andrés Rodríguez-Sacristán, Susana González-Granero, José Manuel García-Verdugo, José A. Sánchez-Alcázar   +14 more
doaj   +2 more sources

Boosting energy metabolism and biosynthesis in diverse organisms by a common bacterial salvage lipoylation protein [PDF]

Nature Communications
Lipoylation is a highly conserved post-translational modification (PTM) crucial for energy metabolism enzymes, with distinct pathways across organisms. Whereas bacteria like Escherichia coli inherit both salvage and de novo pathways, only the latter is ...
Runqing Yang, Yingying Wang, Minghua Kong, Zhijuan Hu, Zhe Zhang, Kun Shen, Jiali Meng, An-Ping Zeng   +7 more
doaj   +2 more sources