Results 41 to 50 of about 4,163 (149)
Navigating Transition Metal‐Dependent Cell Death: Mechanisms, Crosstalk, and Future Directions
Advanced Science, Volume 12, Issue 46, December 11, 2025.Transition metals trigger distinct regulated cell death pathways beyond traditional apoptosis. This review examines ferroptosis (iron‐catalyzed lipid peroxidation) and cuproptosis (copper‐induced mitochondrial proteotoxicity), while exploring hypothetical “cobaltosis” as a novel pathway.
Qinghang Song, Yuxuan Yang, Lina Yang
wiley +1 more source
Distinctive phosphoinositide- and Ca²⁺-binding properties of normal and cognitive performance–linked variant forms of KIBRA C2 domain [PDF]
, 2018 Kidney- and brain-expressed protein (KIBRA), a multifunctional scaffold protein with around 20 known binding partners, is involved in memory and cognition, organ size control via the Hippo pathway, cell polarity, and membrane trafficking.
Bagby, S +8 more
core +2 more sources
MedComm, Volume 6, Issue 12, December 2025.Radiation‐induced biological effects are an extremely complex and extensive mechanism that involves multiple aspects of physiological activities in organisms. In the medical field, utilizing the damaging effects of radiation to treat tumors is a commonly employed therapeutic approach.
Zhihe Hu +5 more
wiley +1 more source
Richard Nelson Perham. 27 April 1937—14 February 2015 [PDF]
, 2018 Richard Nelson Perham, FRS, FMedSci, FRSA, was a British professor of structural biochemistry. He undertook his academic career at the University of Cambridge, holding positions as lecturer, reader, chair and head of the Department of Biochemistry, as ...
Aikens R. +5 more
core +3 more sources
CoA-dependent activation of mitochondrial acyl carrier protein links four neurodegenerative diseases [PDF]
, 2019 PKAN, CoPAN, MePAN, and PDH-E2 deficiency share key phenotypic features but harbor defects in distinct metabolic processes. Selective damage to the globus pallidus occurs in these genetic neurodegenerative diseases, which arise from defects in CoA ...
Autio, Kaija J +10 more
core +2 more sources
Advanced Science, Volume 12, Issue 43, November 20, 2025.A titanium implant coating integrating berberine and copper‐doped strontium titanate leverages ultrasound to compromise bacterial membranes and induce cuproptosis‐like death. This approach resolves S. aureus infections in osteomyelitis models while suppressing inflammation and promoting osseointegration, demonstrating a dual‐functional strategy against
Guannan Zhang +8 more
wiley +1 more source
The Fe-S cluster assembly factors NFU4 and NFU5 are primarily required for protein lipoylation in mitochondria [PDF]
, 2021 Jonathan Przybyla‐Toscano +7 more
openalex +1 more source
Mechanism and role of regulated cell death in tumor immunity and immunotherapy
Cancer Communications, Volume 45, Issue 11, Page 1456-1495, November 2025.Abstract Cancer immune checkpoint inhibitors (ICIs) have brought breakthroughs, but only about one‐third of cancer patients benefit from ICIs. In recent years, targeting non‐apoptotic regulated cell death (RCD) subtypes, such as ferroptosis, necroptosis, autophagy, cuproptosis, and pyroptosis, has emerged as a novel strategy in cancer therapy due to ...
Jingwen Hu +4 more
wiley +1 more source
Protein lipoylation in mitochondria requires Fe–S cluster assembly factors NFU4 and NFU5 [PDF]
, 2021 Jonathan Przybyla‐Toscano +7 more
openalex +1 more source
Mitochondrial Fatty Acids and Neurodegenerative Disorders [PDF]
, 2020 Fatty acids in mitochondria, in sensu stricto, arise either as β-oxidation substrates imported via the carnitine shuttle or through de novo synthesis by the mitochondrial fatty acid synthesis (mtFAS) pathway. Defects in mtFAS or processes involved in the
Autio, Kaija J. +2 more
core +1 more source