Results 171 to 180 of about 3,006,723 (410)

Stable, Easy‐to‐Handle, Fully Autologous Electrospun Polymer‐Peptide Skin Equivalent for Severe Burn Injuries

Advanced Functional Materials, EarlyView.
A bioengineered skin equivalent composed of electrospun poly(ε‐caprolactone) (PCL) and the bioactive peptide Fmoc‐FRGD is developed for severe burn treatment. This scaffold promotes full‐thickness skin regeneration by supporting cellular adhesion and integration. In‐vitro and in‐vivo studies show enhanced mechanical stability, accelerated wound closure,
Dana Cohen‐Gerassi, Marina BenShoshan, Adi Liiani, Tomer Reuveni, Offir Loboda, Moti Harats, Josef Haik, Itzhak Binderman, Yosi Shacham‐Diamand, Amit Sitt, Ayelet Di Segni, Lihi Adler‐Abramovich   +11 more
wiley   +1 more source

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source

Early detection of pancreatic cancer by liquid biopsy “PANLIPSY”: a french nation-wide study project

BMC Cancer
Background Pancreatic cancer, predominantly characterized by ductal adenocarcinoma (PDAC) accounts for 90% of cases and is the fourth leading cause of cancer-related deaths globally. Its incidence is notably increasing.
Thomas Bardol, Antoine M. Dujon, Valerie Taly, Catherine Dunyach-Remy, Jean-Philippe Lavigne, Bruno Costa-Silva, Keerthi Kurma, Zahra Eslami-S, Laure Cayrefourcq, Cindy Canivet, Fabrice Muscari, Barbara Bournet, Catherine Alix-Panabières   +12 more
doaj   +1 more source

Obesity dependent metabolic signatures associated with nonalcoholic fatty liver disease progression [PDF]

, 2012
Our understanding of the mechanisms by which nonalcoholic fatty liver disease (NAFLD) progresses from simple steatosis to steatohepatitis (NASH) is still very limited.
Alonso, C, Barr, J, Caballería, J, Domínguez-Díez, A, Martínez Arranz, Ibon, Moto, J.M., Muntané Relat, Jordi, Romero Gómez, Manuel   +7 more
core  

Liquid Biopsy Proteomics in Ophthalmology

Journal of Proteome Research
Minimally invasive liquid biopsies from the eye capture locally enriched fluids that contain thousands of proteins from highly specialized ocular cell types, presenting a promising alternative to solid tissue biopsies. The advantages of liquid biopsies include sampling the eye without causing irreversible functional damage, potentially better ...
Julian Wolf, Joel A. Franco, Rui Yip, Mohamed Ziad Dabaja, Gabriel Velez, Fei Liu, Alexander G. Bassuk, Prithvi Mruthyunjaya, Antoine Dufour, Vinit B. Mahajan   +9 more
openaire   +2 more sources

A Bioengineered Model of the Human Cornea for Preclinical Assessment of Human Ocular Exposure to Environmental Toxicants

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
This paper presents a microphysiological system containing an array of individually addressable living corneal tissues constructed using primary human cells. The bioengineered eye model can simulate acute exposure of the human cornea to different types of environmental toxicants and provides a novel platform for visualization and quantitative ...
Se‐jeong Kim, Ning Guo, Zong Yao Tan, Xing Gao, Pouria Fattahi, Haijiao Liu, Jeehan Chang, Mousa Younesi, Selice Jung, Yewhan Chung, Minkyung Song, Michelle Jung, Dan Dongeun Huh   +12 more
wiley   +1 more source

Liquid biopsies: noninvasive longitudinal monitoring of lung cancer [PDF]

, 2015
Yasuhiro Koh
openalex   +1 more source

Kidney Stone Dissolution By Tetherless, Enzyme‐Loaded, Soft Magnetic Miniature Robots

Advanced Healthcare Materials, EarlyView.
Wireless magnetic robots are developed for kidney stone dissolution. The robots navigate through a urinary tract model from bladder and ureter to renal pelvis with the help of external magnetic fields. The filaments are loaded with urease enzyme which catalyzes urea to carbon dioxide and ammonia, thereby increasing pH to basic regime and supporting ...
Afarin Khabbazian, Lauren Kwong, Aaron Lewis, Erica Liu, Noura Abdelrazec, Anna C. Bakenecker, Nil Fontanals, Guillem Lopez, Samuel Sánchez, Juan Manuel Lopez, Brian Carrillo, Monica Farcas, Chris Kallweit, Alfred C. H. Yu, Mir Behrad Khamesee, Veronika Magdanz   +15 more
wiley   +1 more source

Engineering Assembloids to Mimic Graft‐Host Skeletal Muscle Interaction

Advanced Healthcare Materials, EarlyView.
This study develops a graft‐host skeletal muscle assembloid model combining neuromuscular organoids with tissue‐engineered constructs. Pre‐seeding decellularized muscles with myogenic cells enhances cell migration and axon invasion from the organoid. The model exhibits regenerative capacity following acute damage, advancing the understanding of human ...
Lucia Rossi, Beatrice Auletta, Luigi Sartore, Marco La Placa, Giada Cecconi, Pietro Chiolerio, Edoardo Maghin, Silvia Angiolillo, Eugenia Carraro, Onelia Gagliano, Cecilia Laterza, Nicola Elvassore, Martina Piccoli, Anna Urciuolo   +13 more
wiley   +1 more source

Liquid biopsy and therapeutic response: Circulating tumor cell cultures for evaluation of anticancer treatment [PDF]

, 2016
Bee Luan Khoo, Gianluca Grenci, Tengyang Jing, Ying Bena Lim, Soo Chin Lee, Jean Paul Thiery, Jongyoon Han, Chwee Teck Lim   +7 more
openalex   +1 more source