Results 31 to 40 of about 988 (226)
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Alice in Exile. Anya v strane chudes by Vladimir Nabokov as an Example of Adaptation
Półrocznik Językoznawczy Tertium, 2020 This paper explores a Russian translation of Lewis Carroll’s Alice’s Adventures in Wonderland made by Vladimir Nabokov in 1923. A significant aspect of its emergence relates to the fact that the target text was created when the writer and many other ...
Olga Letka-Spychała
doaj +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina +11 more
wiley +1 more source
Functioning of Literary Anthroponyms in the Works by E. Canetti and K. Hoffer
Научный диалог, 2020 The author studies the works of Austrian writers Elias Canetti “Earwitness. 50 characters” (“Der Ohrenzeuge. 50 Charaktere”) and Klaus Hoffer “In Graz” (“Bei den Bieresch”).
E. M. Shastina, J. K. Kazakova
doaj +1 more source
Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce +72 more
wiley +1 more source
Fostering Innovation: Streamlining Magnetocaloric Materials Research by Digitalization
Advanced Engineering Materials, EarlyView.Magnetocaloric cooling (MCE) is an environmentally friendly refrigeration method with great potential. Optimizing MCE materials involves the preparation and screening of large quantities of samples, which in turn generates a large amount of data. A digitalization approach is presented that uses ontologies, knowledge graphs, and digital workflows to ...
Simon Bekemeier +17 more
wiley +1 more source
Studia Rossica Posnaniensia, 2018 Translation of literary proper names boils down to either accurately rendering their original form / meaning or finding equivalents which have less in common with their original versions.
Konrad Rachut
doaj +1 more source
Advanced Engineering Materials, EarlyView.Building machine‐readable vocabularies for materials science is slow, expert‐driven work. This study benchmarks 13 large language models on two of its first steps: finding candidate terms in engineering articles and deciding where they belong in a class hierarchy.
Thomas Bjarsch +3 more
wiley +1 more source
„Hál’ Istennek abban a könyvben, amibe belekezdtem, nincs Rezeda Kázmér...”
Névtani Értesítő“Thank goodness! in the book I started, there is no Kázmér Rezeda...” A stylistic approach to the translation of Krúdy’s ironic naming Functional cognitive linguistics and cognitive stylistics provide the linguistic background and methodological ...
József Pethő
doaj +1 more source