Results 31 to 40 of about 1,978,943 (206)

Designing Vaccines to Neutralize Effective Toxin Delivery by Enterotoxigenic Escherichia coli

Toxins, 2014
Enterotoxigenic Escherichia coli (ETEC) are a leading cause of diarrheal illness in developing countries. Despite the discovery of these pathogens as a cause of cholera-like diarrhea over 40 years ago, and decades of vaccine development effort, there ...
James M. Fleckenstein, Alaullah Sheikh
doaj   +1 more source

Exchange of the C-terminal part of VP3 from very virulent infectious bursal disease virus results in an attenuated virus with a unique antigenic structure [PDF]

, 2002
Infectious bursal disease virus (IBDV) is the major viral pathogen in the poultry industry. Live attenuated serotype 1 vaccine strains are commonly used to protect susceptible chickens during their first 6 weeks of life. Wild-type serotype 1 IBDV strains
Peeters, B.P.H., ter Huurne, A.A.H.M., Pol, J.M., Hoekman, A.J.W., Huurne, A.A.H.M., ter, Boot, H.J., Gielkens, A.L.J.   +6 more
core   +1 more source

Preparation Of Live Attenuated Vaccine Against Strangles

The Iraqi Journal of Veterinary Medicine, 2007
Live attenuated vaccine of Strept. Equi was prepared by culturing the bacterium in increasing concentration of acriflavin and the vaccine was given by installation in the nose of rabbits.
M. M. Kaisium
doaj   +1 more source

The use of attenuated isolates of Pepino mosaic virus for cross-protection [PDF]

, 2010
Pepino mosaic virus (PepMV) has recently emerged as a highly infectious viral pathogen in tomato crops. Greenhouse trials were conducted under conditions similar to commercial tomato production.
Schenk, M.F., Vermunt, A.M.W., Hamelink, R., Vlugt, R.A.A., van der, Kaarsemaker, R.C., Stijger, C.C.M.M., van der Vlugt, R.A.A.   +6 more
core   +1 more source

Generation of DelNS1 Influenza Viruses: a Strategy for Optimizing Live Attenuated Influenza Vaccines

mBio, 2019
Nonstructural protein 1 (NS1) of influenza virus is a key virulence element with multifunctional roles in virus replication and a potent antagonist of host immune response.
Pui Wang, Min Zheng, Siu-Ying Lau, Pin Chen, Bobo Wing-Yee Mok, Siwen Liu, Honglian Liu, Xiaofeng Huang, Conor J. Cremin, Wenjun Song, Yixin Chen, Yik-Chun Wong, Haode Huang, Kelvin Kai-Wong To, Zhiwei Chen, Ningshao Xia, Kwok-Yung Yuen, Honglin Chen   +17 more
doaj   +1 more source

Development of safe and highly protective live-attenuated SARS-CoV-2 vaccine candidates by genome recoding. [PDF]

, 2021
Safe and effective vaccines are urgently needed to stop the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We construct a series of live attenuated vaccine candidates by large-scale recoding of the SARS-CoV-2 genome and ...
Trimpert, Jakob, Adler, Julia M, Abdelgawad, Azza, Höfler, Thomas, Firsching, Theresa C, Labroussaa, Fabien, Kaufer, Susanne, Thiel, Volker, Vladimirova, Daria, Kunec, Dusan, Ebert, Nadine, Conradie, Andelé, Dietert, Kristina, Tran, Thi Nhu Thao, Bertzbach, Luca D, Jores, Jörg, Gruber, Achim D, Osterrieder, Nikolaus   +17 more
core   +2 more sources

Protective efficacy and DIVA potential of a

Poultry Science
Salmonella Enteritidis poses a significant threat to poultry health and production, leading to substantial economic losses worldwide. Transmission through contaminated poultry products poses a continuous risk to public health.
Yanyu Ruan, Xilong Kang, Zeyun Lin, Tianlong Sun, Zhiming Pan, Xinwei Wang, Tingting Pan, Yimeng Zhao, Hongqin Song   +8 more
doaj   +1 more source

Rational Development of Live-Attenuated Zika Virus Vaccines

Pathogens, 2023
Zika virus (ZIKV), a re-emerging mosquito-borne flavivirus, has caused outbreaks in Africa, Asia, the Pacific, and, more recently, in the Americas. ZIKV has been associated with the neurological autoimmune disorder Guillain–Barre syndrome in adults and ...
Awadalkareem Adam, Christy Lee, Tian Wang   +2 more
doaj   +1 more source

Attenuation of the influenza virus by microRNA response element in vivo and protective efficacy against 2009 pandemic H1N1 virus in mice

International Journal of Infectious Diseases, 2015
Background: The 2009 influenza pandemics underscored the need for effective vaccines to block the spread of influenza virus infection. Most live attenuated vaccines utilize cold-adapted, temperature-sensitive virus.
Chunlai Feng, Mingming Tan, Wenkui Sun, Yi Shi, Zheng Xing   +4 more
doaj   +1 more source

An oral live attenuated vaccine strategy against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/2019-nCoV) [PDF]

Research Ideas and Outcomes, 2020
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/2019-nCoV) infection has become a pandemic called COVID-19. The virus binds to angiotensin converting enzyme 2 (ACE2) and TMPRSS2 which are abundantly expressed on various human cells including ...
Madhusudana Girija Sanal, Ravi Chandra Duby   +1 more
doaj   +3 more sources