Results 61 to 70 of about 107,308 (356)

Live attenuated pre-erythrocytic malaria vaccines [PDF]

Human Vaccines & Immunotherapeutics, 2014
Although recent control measures have significantly reduced malaria cases and deaths in many endemic areas, an effective vaccine will be essential to eradicate this parasitic disease. Malaria vaccine strategies developed to date focus on different phases of the parasite's complex life cycle in the human host and mosquito vector, and include both ...
Gladys J, Keitany, Marissa, Vignali, Ruobing, Wang   +2 more
openaire   +2 more sources

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, EarlyView.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source

Comparative evaluation of live attenuated and killed tachyzoites as vaccine candidates for toxoplasmosis

AMB Express
Toxoplasma gondii (T.gondii) an obligate intracellular protozoan, causes toxoplasmosis, leading to significant economic losses and posing serious public health challenges worldwide.
Eman E. El Shanawany, Eman H. Abdel-Rahman, Waleed A. Nemr, Soad E. Hassan, Noha M. F. Hassan, Hassan M. Desouky, Rabab Zalat, Amany Ebrahim Nofal, Raafat M. Shaapan, Salwa Sami Younis   +9 more
doaj   +1 more source

Reduced immunogenicity of a live Salmonella enterica serovar Typhimurium vaccine in aged mice

Frontiers in Immunology, 2023
IntroductionNon-typhoidal Salmonella (NTS) is responsible for a high burden of foodborne infections and deaths worldwide. In the United States, NTS infections are the leading cause of hospitalizations and deaths due to foodborne illnesses, and older ...
Jessica C. Allen, Jessica C. Allen, Franklin R. Toapanta, Franklin R. Toapanta, Scott M. Baliban, Scott M. Baliban, Marcelo B. Sztein, Marcelo B. Sztein, Marcelo B. Sztein, Sharon M. Tennant, Sharon M. Tennant   +10 more
doaj   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Multitasking Smart Intestinal Capsule Robot: A Cutting‐Edge Platform for Sampling, Diagnosis, and Therapy

Advanced Robotics Research, EarlyView.
Gut microbiota and biomarkers are linked to diseases like neurological disorders and metabolic syndromes. Ingestible capsule robots enable minimally invasive gut health assessment. This article proposes a promising direction for the advancement of capsule robots, integrating in situ sampling, real‐time diagnostics, and personalized therapy.
Xizong Chen, Libing Huang, Lei Ren, Miao Wang   +3 more
wiley   +1 more source

Liposomal Delivery of the RNA Genome of a Live-Attenuated Chikungunya Virus Vaccine Candidate Provides Local, but Not Systemic Protection After One Dose

Frontiers in Immunology, 2020
Chikungunya virus (CHIKV) is the causative pathogen of chikungunya fever, a mosquito-borne viral disease causing highly debilitating arthralgia that can persist for months and progress to chronic arthritis.
Eranga Abeyratne, Eranga Abeyratne, Kothila Tharmarajah, Kothila Tharmarajah, Joseph R. Freitas, Joseph R. Freitas, Helen Mostafavi, Helen Mostafavi, Suresh Mahalingam, Suresh Mahalingam, Ali Zaid, Ali Zaid, Mehfuz Zaman, Adam Taylor, Adam Taylor   +14 more
doaj   +1 more source

Enrollment in YFV Vaccine Trial: An Evaluation of Recruitment Outcomes Associated with a Randomized Controlled Double-Blind Trial of a Live Attenuated Yellow Fever Vaccine

, 2013
This investigation evaluated several factors associated with diverse participant enrollment of a clinical trial assessing safety, immunogenicity, and comparative viremia associated with administration of 17-D live, attenuated yellow fever vaccine given ...
Edupuganti, Srilatha, Frew, Paula M., Keyserling, Harry L., Lu, Lu, Mulligan, Mark J., Shapiro, Eve T.   +5 more
core   +1 more source

Formulation of a live bacterial vaccine for stable room temperature storage results in loss of acid, bile and bile salt resistance [PDF]

, 2008
Live bacterial vaccines have great promise both as vaccines against enteric pathogens and as heterologous antigen vectors against diverse diseases. Ideally, room temperature stable dry formulations of live bacterial vaccines will allow oral vaccination ...
Edwards, Alexander D., Slater, Nigel K.H.   +1 more
core   +1 more source

A live attenuated varicella vaccine

Uirusu, 2009
The vaccine virus was isolated from a vesicle of a 3-year-old otherwise healthy boy called Oka (his family name) who had typical varicella. This virus was passaged through human embryonic lung cells, guinea pig embryonic cells at a low temperature, and human diploid cells (WI-38). It was then adapted to MRC-5 human diploid cells for vaccine preparation.
openaire   +3 more sources