Results 1 to 10 of about 12,350,953 (264)

Critical Role of microRNA-21 in the Pathogenesis of Liver Diseases [PDF]

Frontiers in Medicine, 2020
MicroRNAs are small non-coding RNAs that range in length from 18 to 24 nucleotides. As one of the most extensively studied microRNAs, microRNA-21 (miR-21) is highly expressed in many mammalian cell types.
Han, Sen, Kusumanchi, Praveen, Liangpunsakul, Suthat, Yang, Zhihong, Zhang, Ting   +4 more
core   +2 more sources

Characteristics and Clinical Significance of Intestinal Microbiota in Patients with Chronic Hepatitis B Cirrhosis and Type 2 Diabetes Mellitus

Journal of Diabetes Research, 2022
Background. Chronic hepatitis B cirrhosis is often accompanied by glucose metabolism disorder, and intestinal microbiota was closely related to both cirrhosis and diabetes.
Xiu Sun, Xin Chi, Yingying Zhao, Shunai Liu, Huichun Xing   +4 more
doaj   +1 more source

Endoplasmic Reticulum Stress in Liver Diseases.

Hepatology, 2022
The endoplasmic reticulum (ER) is an intracellular organelle that fosters the correct folding of linear polypeptides and proteins, a process tightly governed by the ER-resident enzymes and chaperones.
Amir Ajoolabady, N. Kaplowitz, C. Lebeaupin, G. Kroemer, R. Kaufman, H. Malhi, Jun Ren   +6 more
semanticscholar   +1 more source

Fenofibrate in primary sclerosing cholangitis; a randomized, double‐blind, placebo‐controlled trial

Pharmacology Research & Perspectives, 2022
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with no medical treatment proven to improve survival and postpone liver transplantation. Previous studies have shown the effectiveness of fibrates in primary biliary cholangitis.
Behzad Hatami, Mozhde Mosala, Amir Hossein Hassani, Mohammad Javad Ehsani Ardakani, Samira Gholami, Mohammad Reza Zali   +5 more
doaj   +1 more source

Pathophysiological Roles of Mucosal-Associated Invariant T Cells in the Context of Gut Microbiota-Liver Axis

Microorganisms, 2021
Mucosal-associated invariant T (MAIT) cells are a subset of T lymphocytes expressing a semi-invariant T-cell receptor (TCR) present as TCR Vα7.2-Jα33 in humans and TCR Vα19-Jα33 in mice.
Yoseph Asmelash Gebru, Mi Ran Choi, Ganesan Raja, Haripriya Gupta, Satya Priya Sharma, Ye Rin Choi, Hyeong Seop Kim, Sang Jun Yoon, Dong Joon Kim, Ki Tae Suk   +9 more
doaj   +1 more source

The Nrf2 Pathway in Liver Diseases

Frontiers in Cell and Developmental Biology, 2022
Oxidative stress is the leading cause of most liver diseases, such as drug-induced liver injury, viral hepatitis, and alcoholic hepatitis caused by drugs, viruses, and ethanol.
Jiaming Zhou, Q. Zheng, Zhi H. Chen
semanticscholar   +1 more source

Dynamic changes of phenotype and function of natural killer cells in peripheral blood before and after thermal ablation of hepatitis B associated hepatocellular carcinoma and their correlation with tumor recurrence

BMC Cancer, 2023
Background Thermal therapy induces an immune response in patients with hepatocellular carcinoma (HCC), but the dynamic characteristics of the natural killer (NK) cell immune response post-thermal ablation remain unclear.
Hai-Yan Wang, Xiong-Wei Cui, Yong-Hong Zhang, Yu Chen, Ning-Ning Lu, Li Bai, Zhong-Ping Duan   +6 more
doaj   +1 more source

Periodontitis, chronic liver diseases, and the emerging oral‐gut‐liver axis

Periodontology, 2022
The liver carries out a wide range of functions ranging from the control of metabolites, nutrient storage, and detoxification to immunosurveillance. While inflammation is essential for the tissue remodeling and maintenance of homeostasis and normal liver
E. Albuquerque‐Souza, S. E. Sahingur
semanticscholar   +1 more source

Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis [PDF]

, 2020
Background A non-invasive method to grade the severity of steatohepatitis and liver fibrosis is magnetic resonance imaging (MRI) based corrected T1 (cT1).
Banerjee, R, Banerjee, R, Bell, J.D., Bell, J.D., Hemingway, H., Hemingway, H., Hingorani, A.D., Hingorani, A.D., Kelly, M., Kelly, M., McGonigle, J., McGonigle, J., Neubauer, S., Neubauer, S., Nicholls, R.C., Nicholls, R.C., Parisinos, C.A., Parisinos, C.A., Patel, R.S., Patel, R.S., Thomas, E.L., Thomas, E.L., Wilman, H., Wilman, H., Yaghootkar, H., Yaghootkar, H.   +25 more
core   +3 more sources

Oxidative Stress, Genomic Integrity, and Liver Diseases

Molecules, 2022
Excess reactive oxygen species production and free radical formation can lead to oxidative stress that can damage cells, tissues, and organs. Cellular oxidative stress is defined as the imbalance between ROS production and antioxidants.
Nanthini Sadasivam, Yu-ji Kim, K. Radhakrishnan, Don-Kyu Kim   +3 more
semanticscholar   +1 more source