Results 1 to 10 of about 11,903,041 (385)

Critical Role of microRNA-21 in the Pathogenesis of Liver Diseases [PDF]

open access: yesFrontiers in Medicine, 2020
MicroRNAs are small non-coding RNAs that range in length from 18 to 24 nucleotides. As one of the most extensively studied microRNAs, microRNA-21 (miR-21) is highly expressed in many mammalian cell types.
Han, Sen   +4 more
core   +2 more sources

Fenofibrate in primary sclerosing cholangitis; a randomized, double‐blind, placebo‐controlled trial

open access: yesPharmacology Research & Perspectives, 2022
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with no medical treatment proven to improve survival and postpone liver transplantation. Previous studies have shown the effectiveness of fibrates in primary biliary cholangitis.
Behzad Hatami   +5 more
doaj   +1 more source

Endoplasmic Reticulum Stress in Liver Diseases.

open access: yesHepatology, 2022
The endoplasmic reticulum (ER) is an intracellular organelle that fosters the correct folding of linear polypeptides and proteins, a process tightly governed by the ER-resident enzymes and chaperones.
Amir Ajoolabady   +6 more
semanticscholar   +1 more source

Characteristics and Clinical Significance of Intestinal Microbiota in Patients with Chronic Hepatitis B Cirrhosis and Type 2 Diabetes Mellitus

open access: yesJournal of Diabetes Research, 2022
Background. Chronic hepatitis B cirrhosis is often accompanied by glucose metabolism disorder, and intestinal microbiota was closely related to both cirrhosis and diabetes.
Xiu Sun   +4 more
doaj   +1 more source

The Nrf2 Pathway in Liver Diseases

open access: yesFrontiers in Cell and Developmental Biology, 2022
Oxidative stress is the leading cause of most liver diseases, such as drug-induced liver injury, viral hepatitis, and alcoholic hepatitis caused by drugs, viruses, and ethanol.
Jiaming Zhou, Q. Zheng, Zhi H. Chen
semanticscholar   +1 more source

Pathophysiological Roles of Mucosal-Associated Invariant T Cells in the Context of Gut Microbiota-Liver Axis

open access: yesMicroorganisms, 2021
Mucosal-associated invariant T (MAIT) cells are a subset of T lymphocytes expressing a semi-invariant T-cell receptor (TCR) present as TCR Vα7.2-Jα33 in humans and TCR Vα19-Jα33 in mice.
Yoseph Asmelash Gebru   +9 more
doaj   +1 more source

Dynamic changes of phenotype and function of natural killer cells in peripheral blood before and after thermal ablation of hepatitis B associated hepatocellular carcinoma and their correlation with tumor recurrence

open access: yesBMC Cancer, 2023
Background Thermal therapy induces an immune response in patients with hepatocellular carcinoma (HCC), but the dynamic characteristics of the natural killer (NK) cell immune response post-thermal ablation remain unclear.
Hai-Yan Wang   +6 more
doaj   +1 more source

Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis [PDF]

open access: yes, 2020
Background A non-invasive method to grade the severity of steatohepatitis and liver fibrosis is magnetic resonance imaging (MRI) based corrected T1 (cT1).
Banerjee, R   +25 more
core   +3 more sources

Diagnosis and Treatment of Alcohol‐Associated Liver Diseases: 2019 Practice Guidance From the American Association for the Study of Liver Diseases

open access: yesHepatology, 2020
Alcoholic liver disease (ALD) represents a spectrum of liver injury resulting from alcohol use, ranging from hepatic steatosis to more advanced forms including alcoholic hepatitis (AH), alcoholic cirrhosis (AC), and acute alcoholic hepatitis presenting ...
D. Crabb   +4 more
semanticscholar   +1 more source

Bile Acid Receptor Therapeutics Effects on Chronic Liver Diseases [PDF]

open access: yes, 2020
In the past ten years, our understanding of the importance of bile acids has expanded from fat absorption and glucose/lipid/energy homeostasis into potential therapeutic targets for amelioration of chronic cholestatic liver diseases.
Alpini, Gianfranco   +4 more
core   +1 more source

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