Results 1 to 10 of about 2,424,188 (403)

Animal and Organoid Models of Liver Fibrosis

Frontiers in Physiology, 2021
Liver fibrosis refers to the process underlying the development of chronic liver diseases, wherein liver cells are repeatedly destroyed and regenerated, which leads to an excessive deposition and abnormal distribution of the extracellular matrix such as ...
Yu-long Bao, Li Wang, Hai-ting Pan, Tai-ran Zhang, Ya-hong Chen, Shan-jing Xu, Xin-li Mao, Xin-li Mao, Xin-li Mao, Shao-wei Li, Shao-wei Li   +10 more
doaj   +2 more sources

Liver Fibrosis Biomarkers Accurately Exclude Advanced Fibrosis and Are Associated with Higher Cardiovascular Risk Scores in Patients with NAFLD or Viral Chronic Liver Disease

Diagnostics, 2021
Liver fibrosis predicts liver-related and cardiovascular outcomes in chronic liver disease patients. We compared the diagnostic performance of various liver fibrosis biomarkers for identifying histological significant/advanced fibrosis. Additionally, the
Stefano Ballestri, Alessandro Mantovani, Enrica Baldelli, Simonetta Lugari, Mauro Maurantonio, Fabio Nascimbeni, Alessandra Marrazzo, Dante Romagnoli, Giovanni Targher, Amedeo Lonardo   +9 more
doaj   +2 more sources

The roles and mechanisms of hypoxia in liver fibrosis

Journal of Translational Medicine, 2021
Liver fibrosis occurs in response to any etiology of chronic liver injury. Lack of appropriate clinical intervention will lead to liver cirrhosis or hepatocellular carcinoma (HCC), seriously affecting the quality of life of patients, but the current ...
Jingyao Cai, Min Hu, Zhiyang Chen, Zeng Ling   +3 more
doaj   +2 more sources

Liver Fibrosis: Therapeutic Targets and Advances in Drug Therapy

Frontiers in Cell and Developmental Biology, 2021
Liver fibrosis is an abnormal wound repair response caused by a variety of chronic liver injuries, which is characterized by over-deposition of diffuse extracellular matrix (ECM) and anomalous hyperplasia of connective tissue, and it may further develop ...
Zui Tan, Hongbao Sun, Taixiong Xue, Cailing Gan, Hongyao Liu, Yuting Xie, Yuqin Yao, Tinghong Ye   +7 more
doaj   +2 more sources

Opportunities and Challenges of Surveillance for Liver Cancer in Primary Care Institutions in China [PDF]

Zhongguo quanke yixue, 2023
Primary liver cancer (PLC) is one of the common malignant tumors and the main causes of tumor death in China. Although the diagnosis and treatment technology of PLC in China has made great progress in recent years, its morbidity and mortality have been ...
WANG Shiyue, DONG Chen, CHANG Chudi, NAN Yuemin
doaj   +1 more source

Machine learning-based predictive and risk analysis using real-world data with blood biomarkers for hepatitis B patients in the malignant progression of hepatocellular carcinoma

Frontiers in Immunology, 2022
Hepatitis B Virus (HBV) infection may lead to various liver diseases such as cirrhosis, end-stage liver complications, and Hepatocellular carcinoma (HCC).
Yuemin Nan, Suxian Zhao, Xiaoxiao Zhang, Zhifeng Xiao, Ruihan Guo   +4 more
doaj   +1 more source

Endotrophin, a pro-peptide of Type VI collagen, is a biomarker of survival in cirrhotic patients with hepatocellular carcinoma

Hepatic Oncology, 2021
Aim: Type VI collagen, is emerging as a signaling collagen originating from different types of fibroblasts. A specific fragment of Type VI collagen, the pro-peptide, is also known as the hormone endotrophin.
Diana Julie Leeming, Signe Holm Nielsen, Roslyn Vongsuvanh, Pruthviraj Uchila, Mette Juul Nielsen, Alexander L Reese-Petersen, David van der Poorten, Mohammed Eslam, Detlef Schuppan, Morten Asser Karsdal, Jacob George   +10 more
doaj   +1 more source

Liver Fibrosis Resolution: From Molecular Mechanisms to Therapeutic Opportunities

International Journal of Molecular Sciences, 2023
The liver is a critical system for metabolism in human beings, which plays an essential role in an abundance of physiological processes and is vulnerable to endogenous or exogenous injuries. After the damage to the liver, a type of aberrant wound healing
Qiying Pei, Qian Yi, Liling Tang
semanticscholar   +1 more source

Heme oxygenase 1 alleviates nonalcoholic steatohepatitis by suppressing hepatic ferroptosis

Lipids in Health and Disease, 2023
Background Heme oxygenase 1 (HO-1) has an influential but insufficiently investigated effect on ferroptosis, which is a novel form of programmed cell death and may play an effect on nonalcoholic steatohepatitis (NASH).
Xiwei Yuan, Lu Li, Ying Zhang, Rong Ai, Dongdong Li, Yao Dou, Mengmeng Hou, Dandan Zhao, Suxian Zhao, Yuemin Nan   +9 more
doaj   +1 more source

Prevalence of liver steatosis and fibrosis in the general population and various high-risk populations: a nationwide study with 5.7 million adults in China.

Gastroenterology, 2023
BACKGROUND & AIMS This study aimed to estimate the prevalence of liver steatosis and fibrosis in the general population and populations with potential risk factors in China, so as to inform policies for the screening and management of fatty liver disease
S. Man, Yuhan Deng, Yuan Ma, Jingzhu Fu, Heling Bao, Canqing Yu, J. Lv, Hui Liu, Bo Wang, Liming Li   +9 more
semanticscholar   +1 more source