Results 1 to 10 of about 14,339 (50)

Heme oxygenase 1 alleviates nonalcoholic steatohepatitis by suppressing hepatic ferroptosis

Lipids in Health and Disease, 2023
Background Heme oxygenase 1 (HO-1) has an influential but insufficiently investigated effect on ferroptosis, which is a novel form of programmed cell death and may play an effect on nonalcoholic steatohepatitis (NASH).
Xiwei Yuan, Lu Li, Ying Zhang, Rong Ai, Dongdong Li, Yao Dou, Mengmeng Hou, Dandan Zhao, Suxian Zhao, Yuemin Nan   +9 more
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Machine learning-based predictive and risk analysis using real-world data with blood biomarkers for hepatitis B patients in the malignant progression of hepatocellular carcinoma

Frontiers in Immunology, 2022
Hepatitis B Virus (HBV) infection may lead to various liver diseases such as cirrhosis, end-stage liver complications, and Hepatocellular carcinoma (HCC).
Yuemin Nan, Suxian Zhao, Xiaoxiao Zhang, Zhifeng Xiao, Ruihan Guo   +4 more
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Endotrophin, a pro-peptide of Type VI collagen, is a biomarker of survival in cirrhotic patients with hepatocellular carcinoma

Hepatic Oncology, 2021
Aim: Type VI collagen, is emerging as a signaling collagen originating from different types of fibroblasts. A specific fragment of Type VI collagen, the pro-peptide, is also known as the hormone endotrophin.
Diana Julie Leeming, Signe Holm Nielsen, Roslyn Vongsuvanh, Pruthviraj Uchila, Mette Juul Nielsen, Alexander L Reese-Petersen, David van der Poorten, Mohammed Eslam, Detlef Schuppan, Morten Asser Karsdal, Jacob George   +10 more
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Opportunities and Challenges of Surveillance for Liver Cancer in Primary Care Institutions in China [PDF]

Zhongguo quanke yixue, 2023
Primary liver cancer (PLC) is one of the common malignant tumors and the main causes of tumor death in China. Although the diagnosis and treatment technology of PLC in China has made great progress in recent years, its morbidity and mortality have been ...
WANG Shiyue, DONG Chen, CHANG Chudi, NAN Yuemin
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Glutamate-Cysteine Ligase Catalytic Subunit Attenuated Hepatitis C Virus-Related Liver Fibrosis and Suppressed Endoplasmic Reticulum Stress

Frontiers in Molecular Biosciences, 2020
The study aimed to clarify the role and molecular mechanism of glutamate-cysteine ligase catalytic subunit (GCLC) in modulating Hepatitis C virus (HCV)-related liver fibrosis.
Na Fu, Na Fu, Dongdong Li, Dongdong Li, Wencong Li, Wencong Li, Wen Zhao, Wen Zhao, Siyu Zhang, Siyu Zhang, Lingdi Liu, Lingdi Liu, Suxian Zhao, Suxian Zhao, Jinghua Du, Jinghua Du, Lingbo Kong, Lingbo Kong, Rongqi Wang, Rongqi Wang, Yuguo Zhang, Yuguo Zhang, Yuemin Nan, Yuemin Nan   +23 more
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Animal and Organoid Models of Liver Fibrosis

Frontiers in Physiology, 2021
Liver fibrosis refers to the process underlying the development of chronic liver diseases, wherein liver cells are repeatedly destroyed and regenerated, which leads to an excessive deposition and abnormal distribution of the extracellular matrix such as ...
Yu-long Bao, Li Wang, Hai-ting Pan, Tai-ran Zhang, Ya-hong Chen, Shan-jing Xu, Xin-li Mao, Xin-li Mao, Xin-li Mao, Shao-wei Li, Shao-wei Li   +10 more
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In Vivo and In Vitro Models to Study Liver Fibrosis: Mechanisms and LimitationsSummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Liver fibrosis is a common result of liver injury owing to various kinds of chronic liver diseases. A deeper understanding of the pathophysiology of liver fibrosis and identifying potential therapeutic targets of liver fibrosis is important because liver
Young-Sun Lee, Ekihiro Seki
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Inhibiting IRE1α-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma

eLife, 2020
Hepatocellular carcinoma (HCC) is a liver tumor that usually arises in patients with cirrhosis. Hepatic stellate cells are key players in the progression of HCC, as they create a fibrotic micro-environment and produce growth factors and cytokines that ...
Nataša Pavlović, Carlemi Calitz, Kess Thanapirom, Guiseppe Mazza, Krista Rombouts, Pär Gerwins, Femke Heindryckx   +6 more
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Liver Fibrosis Biomarkers Accurately Exclude Advanced Fibrosis and Are Associated with Higher Cardiovascular Risk Scores in Patients with NAFLD or Viral Chronic Liver Disease

Diagnostics, 2021
Liver fibrosis predicts liver-related and cardiovascular outcomes in chronic liver disease patients. We compared the diagnostic performance of various liver fibrosis biomarkers for identifying histological significant/advanced fibrosis. Additionally, the
Stefano Ballestri, Alessandro Mantovani, Enrica Baldelli, Simonetta Lugari, Mauro Maurantonio, Fabio Nascimbeni, Alessandra Marrazzo, Dante Romagnoli, Giovanni Targher, Amedeo Lonardo   +9 more
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Assessment and validation of the TREAT-B score to assess the treatment eligibility of patients with chronic hepatitis B virus infection

Frontiers in Medicine, 2022
Background and aimsAccess to Hepatitis B virus (HBV) DNA testing to determine treatment eligibility is limited in low-income countries. Therefore, this study aimed to assess and validate the TREAT-B score proposed as the treatment threshold in an Asian ...
Kessarin Thanapirom, Kessarin Thanapirom, Kessarin Thanapirom, Sirinporn Suksawatamnuay, Sirinporn Suksawatamnuay, Sirinporn Suksawatamnuay, Panarat Thaimai, Panarat Thaimai, Panarat Thaimai, Sombat Treeprasertsuk, Piyawat Komolmit, Piyawat Komolmit, Piyawat Komolmit, Pisit Tangkijvanich   +13 more
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